The Human Upgrade: Biohacking for Longevity & Performance

What if the secret to living to 250 was simply sitting in the garden?  In this episode, Dave sits down with Christian Drapeau, a leading expert in stem cell science, to explore the plants and natural practices that could unlock extreme longevity. From goji berries to reishi mushrooms, these age-old remedies do more than nourish—they activate your body’s innate repair system, boosting stem cel...

Are we protecting our kids—or unknowingly putting their health at risk?  Dr. Joel “Gator” Warsh isn’t just another pediatrician; he’s a bold voice speaking out on the vaccine debate that’s dividing parents, doctors, and society. In this episode, we pull back the curtain on one of the most censored and controversial topics of our time.  With his integrative and functional approach, Dr. Wa...

Your hearing isn’t just about sound—it’s the key to sharper focus, deeper connections, and increased awareness. In this episode, Dave explores the cutting-edge world of hearing technology with Brandon Sawalich, CEO of Starkey, and reveals how you can gain superhuman hearing with almost no effort. “Listening” to this episode is going to be one of the best things for your hearing. But why? Because y...

Fear is quietly running your life—and it’s holding you back from the purpose and success you deserve. In this episode, we revisit Dave chatting with one of the keynote speakers for the Biohacking Conference 2025, Ryan Holiday, the bestselling author of  Courage Is Calling , to tackle the one thing standing between you and your potential: fear.  Why should you listen? Because fear is...

Today we are bringing back one of our all-time favorite episodes with James Altucher.  Dave sits down with James, an entrepreneur, bestselling author, and master experimenter, to uncover why the 10,000-hour rule might just be holding you back. Instead of grinding your way to expertise, James reveals his 10,000 Experiment Rule—a game-changing approach to mastering any skill faster than you tho...

Can you use hate to make the world a better place?   Daryl Davis, a world-class jazz musician, didn’t just confront hate—he dismantled it. By sitting down with over 200 Ku Klux Klan members, he inspired them to leave their robes behind. But this isn’t just a story about racism or redemption; it’s a story about the incredible power of human connection and the lessons it holds for all of us.&nb...

Is AI About to Replace Your Doctor? Or Save Your Life?   The tools that are reshaping healthcare will redefine medicine—and your life—in ways you’ve never imagined. Will artificial intelligence and regenerative therapies like stem cells and exosomes make doctors obsolete? Or will they finally unlock the secrets to living to 180?  In this episode, Dave sits down with Dr. Pradeep Albe...

Most people don’t think about their liver until it’s too late.  In this episode, Dave sits down with Siggi Clavien, founder of de-liver-ance® & The Liver Clinic, to uncover the hidden superpowers of the body’s most underrated organ: the liver. This is a deep dive into why your liver is the ultimate game-changer for your energy, brain power, and longevity.  Siggi reveals gro...

Will the next nuclear bomb be AI Superintelligence?   The intelligence we’re building will reshape the world in ways we never imagined—for better or worse? But more importantly, what side will humanity take?  In this episode, Mo Gawdat, bestselling author of  Scary Smart  and former Chief Business Officer of Google X, joins Dave to tackle the profound challenges and opportuniti...

Can Happiness Really Be Engineered? Mo Gawdat Says Yes—And Here’s How.   I know what you’re thinking… ANOTHER episode on happiness? Haven’t we heard it all before? This one’s different. The code is cracked, and you’re about to learn exactly how it works.  Joining us today is Mo Gawdat, bestselling author of Unstressable and former Chief Business Officer of Google X. Mo sits down wit...

Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit?   Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit...

What are the oral hygiene tips that could save your life?   Dave Asprey sits down with one of the most popular guests on the show, Naveen Jain, founder and CEO of Viome Life Sciences, to explore how your oral microbiome influences not just your dental health but your entire body. Naveen reveals groundbreaking insights into how imbalances in oral bacteria can trigger chronic inflammation, hear...

Is this the missing link in fertility?   The vaginal microbiome could be the most overlooked factor in optimizing women’s health, from fertility and hormonal balance to preventing infections and improving quality of life. In this groundbreaking episode, Dave Asprey talks to Priyanka Jain, co-founder and CEO of Evvy, about how understanding and improving the vaginal microbiome can transform wo...

Is alcohol losing its grip as the go-to social drink?   Enter kava—a centuries-old Polynesian plant that’s gaining global recognition for its ability to relax the mind, elevate mood, and enhance social connection without the toxic effects of alcohol. Kava, particularly in the form of TRU KAVA, is a psychoactive yet non-intoxicating drink that offers the perfect balance of calm focus and menta...

Have we finally discovered the key to youthful energy, longevity, and cellular health?   In this episode, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer at Timeline Nutrition and a leading expert on mitochondrial health, cellular regeneration, and anti-aging science. With over 20 years of research, 50 clinical trials, and 15 patents under his belt, Dr. Singh unpacks the gr...

Are exosomes the planet’s ultimate healing tool?!   In this episode, Dave Asprey sits down with Harvard-trained physician Dr. Edward Park to explore the groundbreaking science of exosomes. Dr. Park, a pioneer in regenerative medicine and author of Exosomes: Songs of Healing , explains how these tiny cellular messengers are revolutionizing health and longevity by bypassing the limitations of s...

Is biohacking your sweat the secret to vitality?   Dave Asprey dives into the transformative world of infrared saunas with Connie Zack, founder of Sunlighten and a 25-year innovator in the space. Together, they uncover how targeted light and heat therapy can unlock unparalleled health benefits, from detoxing heavy metals to energizing your body at the cellular level.  Here’s what you’ll...

What if you could command any room and set boundaries without saying a word?   Dave Asprey sits down with Kasia Urbaniak, founder and CEO of The Academy—a trailblazing school where women learn the true principles of influence and authority. Kasia brings a unique and dynamic perspective, drawing on nearly two decades of experience that includes working as a professional Dominatrix, practicing...

Is unlocking the full potential of your brain even possible, or just a myth from the movie Limitless ?  In this eye-opening episode, neuroscientist and author Dr. Mithu Storoni joins Dave to dive deep into the science of brain optimization for hyper-efficient work performance. Together, they break down the surprising roles of astrocytes in supporting neurons, the influence of the brain’s “blu...

What if the keys to an extraordinary life lie in choices most people wouldn’t dare to make?   In this iconic, unearthed episode, best-selling author and performance pioneer Tim Ferriss joins Dave Asprey to spill the unfiltered truth on smart drugs, insect protein, and the surprising links between sex, creativity, and high performance.  They dig into cutting-edge topics still sparking cur...

What if everything you believe about happiness is wrong?   In this episode, Harvard professor and world-renowned happiness expert Arthur Brooks joins Dave Asprey to unlock the secrets of real happiness, revealing the science behind joy, resilience, and lasting fulfillment. As a bestselling author and co-author with Oprah Winfrey of Build the Life You Want , Arthur has spent decades helping pe...

Explore the science and potential of hypnosis as Dr. David Spiegel, Stanford’s leading expert in mind-body medicine, joins Dave Asprey to reveal how hypnosis can radically enhance cognition, mental clarity, and resilience. In this episode of The Human Upgrade , you’ll learn how hypnosis influences the brain’s most vital networks, including the default mode network and executive control, to break m...

Unlock the mastermind secrets to cognitive enhancement as Dave Asprey shares his ultimate brain-boosting biohacks in this powerful episode of The Human Upgrade . Discover how Dave elevated his IQ, reversed Asperger’s, and overcame brain fog through advanced neurofeedback, BDNF-boosting supplements, mitochondrial enhancers, and the power of the groundbreaking 40 Years of Zen program.  Explore...

Unlock the secret to cellular detox and discover how to cleanse your body from the inside out with Dave Asprey and Jessica Berman in this episode of The Human Upgrade . Explore cutting-edge detox strategies using phosphatidylcholine, Tudca, and butyrate, three powerful molecules designed to remove toxins, microplastics, and endocrine disruptors from your system.  Jessica, co-owner of BodyBio,...

Step into the future of sports performance with The Human Upgrade as Dave Asprey and Aron D’Souza, founder of the Enhanced Games, uncover the controversial world of steroids, gene therapy, peptides, and human enhancement. In this groundbreaking episode, they explore how athletes can push the boundaries of physical and mental performance by embracing cutting-edge science once banned by traditional...