The Human Upgrade: Biohacking for Longevity & Performance

For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong?  Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery— a newly identified essential fatty acid, C15,  that may hold the key to healthier aging and even longer lifespans. Orig...

You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself?  In this episode,  Columbia University psychiatrist and nutritional neuroscience pioneer  Dr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammation and gut dysbiosis to screen-i...

You think, you feel, you  are —but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical?  In this episode,  Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Asprey  to challenge everything you think you know about the mind, reality, and human potential. He explores groundbr...

You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize?  In this episode, Scott Barry Kaufman, Ph. D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets . He reveals how toxic altruism, external valid...

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Your Brain is Lying to You—Here’s How to Take Back Control  Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you?  In this episode,  Bizzie Gold , mind architect and creator of  The Break Method , joins Dave Asprey to expose the  self-deception patte...

Is the Way You Speak Limiting How You Think? For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations. In this mind-bending episode, linguist Daniel Everett, known for challenging Noam Chomsky’s theories, s...

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story?  Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of  genetic optimization —how understanding your DNA can unlock  longer life, better brain f...

For years, we’ve been told that willpower and repetition are the keys to forming habits. But the truth is,  habits don’t stick because of repetition—they stick because of emotion!   In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change. BJ, the Stanford researcher behind&...

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective ! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective m...

Can You Mimic Fasting—Without Actually Fasting?  Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal  a groundbreaking fasting mimetic  that could revolutionize how we approach aging, metabolism, and health.  Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sa...

Could a single molecule be the difference between vibrant longevity and early decline?  Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the  real  key to living longer, fighting disease, and maximizing your energy:  NAD.   This master molecule fuels your  mitoch...

Welcome to the metabolism masterclass! Dr. Ben Bikman (Ph. D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about  insulin resistance —the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals  how your hormones, not just your diet, control your metabolism &n...

Most people wait for inspiration. But what if you could train your brain to create on demand?   Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius?  In this must-listen episode, Rick sits down with Dave to explore the  science...

What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle?   Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths a...

From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back?   In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, a...

Could the right form of a single vitamin be the difference between thriving and barely surviving?   In this Part 2 conversation, human biologist and longevity expert  Gary Brecka  reveals the  #1 overlooked factor  that’s wrecking your health:  methylation —your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even menta...

Why were our grandparents stronger, healthier, and living longer—without the “advancements” of modern medicine?  Gary Brecka, one of the world’s leading experts in human longevity and performance, exposes the  hidden crisis  that’s wrecking your hormones, slashing your energy, and cutting your lifespan short. In this no-holds-barred conversation with Dave Asprey, they break down the...

Billy Carson, a Harvard-certified expert in ancient civilizations and an MIT-trained scholar in neuroscience, has spent decades decoding the mysteries of lost technology, quantum reality, and human optimization. Alongside Elisabeth Carson, a biohacker and neuroscience researcher, they bridge the gap between ancient wisdom and modern science—revealing secrets that could transform your mind, body, a...

Everything you’ve been told about weight loss is a lie! In this episode, Dr. Nick Norwitz, a metabolic health expert with accolades from Oxford and Harvard, joins Dave to expose the biggest myth in dieting:  Calorie Counting.  Together, they dismantle outdated weight-loss advice and reveal the truth about metabolism that could revolutionize your health.  Dr. Norwitz shares cutting-e...

What if the key to living longer isn’t avoiding stress—but mastering it  Jeff Krasno, founder of Commune and renowned stress expert, joins Dave to reveal why most of us have stress all wrong. In this fascinating conversation, Jeff redefines how we think about stress—showing how it can be your greatest ally instead of your worst enemy. From his groundbreaking new book Good Stress to the ancien...

What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?  Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can  bend the rules of biology  to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevit...

Is there actual “magic” on this planet, or is it just in the movies?  Dr. Barry Morguelan, a top surgeon and one of only nine living grandmasters of an ancient Lao Tzu lineage, joins Dave to share secrets that have been hidden for 5,000 years. Together, they explore how the principles behind quantum physics, energy mastery, and timeless healing techniques can revolutionize your health, mindse...

What happens when nearly 60 years of combined biohacking expertise collide in one podcast?  Peter Diamandis is a world-renowned futurist, space entrepreneur, and innovator behind groundbreaking ventures like the XPRIZE and Abundance 360. Dave sits down with Peter to combine their nearly 60 years of biohacking expertise, delivering the ultimate playbook for living longer and healthier. They di...

What if you could ditch your glasses forever by simply doing a 10-minute exercise each day?  In this episode, Dave sits down with Dr. Bryce Appelbaum, a visionary in vision biohacking, to uncover how simple techniques can transform your eyesight. From near-far focusing to eye stretches, these exercises don’t just improve your vision—they enhance your brain’s performance, energy, and overall h...