The Human Upgrade: Biohacking for Longevity & Performance

How do you make tough decisions? How do you make them without fear or lying? This episode shows you how unresolved emotions disrupt decision-making, relationships, and functioning in peak brain performance. You’ll learn tips to rewire your nervous system for decision making, optimizing emotional intelligence, and regulating your body for high-level clarity, energy, and resilience. Discover biohack...

Toxins you cannot see are damaging your health, wrecking your metabolism, and quietly accelerating aging. This episode reveals how to detect the new poisons lurking in your home, how they sabotage mitochondria and brain optimization, and the biohacking fixes that restore longevity, energy, and human performance. You’ll learn actionable strategies you can implement right away, from functional medic...

Want to think faster, remember more, and rewire your brain for high performance? This special archived episode breaks down the real nootropic stack, neuroplasticity tools, and brain optimization protocols Jim Kwik uses daily, plus the biohacking routines that rebuilt his cognition after traumatic brain injury.   Watch this episode on YouTube for the full video experience:  https://w...

What if the most powerful upgrades for brain energy, metabolism, and drive aren’t in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you’ll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology.  Watch this episode on YouTube for the full video experience...

Ready to learn about the secret compounds, molecules, nootropics, and stacks that Big Pharma doesn’t want you to know about?  This episode is packed with the exact dopamine-boosting compounds, stacks, and biohacking protocols that top performers are using to supercharge human performance, brain optimization, and long-term resilience.  Watch this episode on YouTube for the full video expe...

Getting  50 grams of protein  per meal may be the single most underrated  biohacking protein  strategy for muscle growth, metabolism, and  longevity . In this episode, you’ll discover why  animal protein vs vegan  is not a fair match biologically, how hitting the  leucine threshold  activates  mTOR for longevity , and why muscle is the most overloo...

This episode reveals how military-grade sound frequencies can rapidly shift your mental state, enhance neuroplasticity, and accelerate brain optimization.  You’ll learn how to hack your nervous system using real-time biometric data, how frequency compositions are changing functional medicine, and why sound is emerging as one of the most powerful tools for human performance and longevity.&nbsp...

You’ve been lied to about how long it takes to change a habit.  This episode reveals a powerful, science-backed method to rewire your brain in just 63 seconds—without relying on willpower. You’ll discover how to use the 63-second window to interrupt destructive thought loops and how true habit change requires 63-day habit formation, not the popularized 21-day myth.  Watch this episode on...

What is  Herbal Ecstasy —and why does it matter? This might be one of the most insane episodes we’ve ever recorded, and we had to bring it back because the story is too wild, too relevant, and too packed with real lessons in biohacking, brain optimization, and supplement hacking to miss.  Host Dave Asprey sits down with Shaahin Cheyene, the renegade teenage entrepreneur who built a billi...

You’re leaving brainpower on the table, and this episode shows you how to reclaim it.  Learn how to boost cognitive performance by 25% without relying on pills, stimulants, or gimmicks. Host Dave Asprey sits down with global finance expert and cross-cultural thinker Richard Conrad to explore how your cultural programming shapes your biology, metabolism, neuroplasticity, and even your ability...

This may be the most cutting-edge life extension technology you’ll hear about for decades. You’ll discover how mitochondrial transfusion, rejuvenation, and repair could reverse biological aging, supercharge your metabolism, and radically extend healthspan—all by upgrading the cellular energy systems that power every function in your body.  Watch this episode on YouTube for the full video expe...

What if one spray could upgrade your brain, protect your mitochondria, and outperform IV therapy and liposomal supplements?  In this episode, you’ll discover the breakthrough science behind  topical glutathione delivery that uses your skin’s  water channels  to raise  intracellular glutathione  levels in just 60 seconds. Learn how this powerful antioxidant works at th...

If you care about longevity, brain optimization, sexual performance, or metabolism, this molecule changes everything.  Host Dave Asprey sits down with nitric oxide pioneer Dr. Nathan Bryan to reveal why this overlooked molecule controls your blood flow, mitochondrial energy, neuroplasticity, insulin response, and even your libido. You’ll learn how nitric oxide acts as a master switch for huma...

Supercharge your mitochondria, slash inflammation, and boost energy with one of the most overlooked hacks in human performance. This episode reveals how just 15 minutes of oxygen-based exercise can radically improve metabolism, brain optimization, and even reverse chronic conditions, without expensive gear or endless protocols.  Watch this episode on YouTube for the full video experience:&nbs...

Wrinkles are just the surface. This episode reveals what’s really happening beneath your skin and how to reverse it using stem cells, regenerative medicine, and the most advanced techniques in plastic surgery and aging. You’ll learn how to improve facial skin tightening, reduce inflammation, and trigger deep skin rejuvenation with stem cells, red light therapy, and targeted procedures that actuall...

Superintelligence is coming faster than anyone predicted. In this episode, you’ll learn how to upgrade your biology, brain, and consciousness before  AI and transhumanism  reshape the future of health. Host Dave Asprey sits down with  Soren Gordhamer , founder of  Wisdom 2.0 , to explore what  superintelligence in 2027  means for your mind, body, and soul.  Watch...

Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades.   Watch this episode on YouTube for the full video experience: ...

What if death isn’t inevitable but a solvable problem? This episode explores how biohacking is reshaping our understanding of mortality, legacy, and the limits of human performance. You’ll learn why some of today’s top thinkers are treating longevity as both a science and a spiritual movement, and how this shift affects your brain, your mitochondria, and your entire approach to life.  Watch t...

You feel stiff, tired, or older than you should—and this episode shows you how to reverse it. Learn how to fix joint pain, restore youthful movement, and upgrade your longevity by hacking the hidden causes of early aging like mitochondrial dysfunction, leaky gut, and chronic inflammation.  Watch this episode on YouTube for the full video experience:   https://www.youtube.com/@DaveAspreyB...

93% of people are metabolically unhealthy, and it’s not because they’re lazy or eating too much fat. It’s because their bodies forgot how to burn fat at all. This episode gives you a complete roadmap to reboot your metabolism, escape the sugar-burning trap, and reignite your fat-burning engine for good.  Watch this episode on YouTube for the full video experience:  https://www.youtube.co...

You’re working out, eating clean, and still not getting the results you want. This episode reveals the real reason your fitness isn’t translating to the summer body you’re chasing and what to do instead.   Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Host Dave Asprey sits down with performance-driven entrepreneur and former A...

Your everyday habits might be accelerating aging, and this episode reveals what to do instead. You’ll learn how specific plants trigger powerful longevity pathways and how to eliminate the hidden toxins disrupting your hormones, brain, mitochondria, and overall health. This is a masterclass in biohacking from two experts who’ve spent decades researching how to upgrade the human body.  Watch t...

Your anti-aging skincare routine might be secretly aging you faster. In this episode, you’ll uncover how trending skincare products including vitamin C serums, harsh exfoliants, and blue light therapies can damage your skin’s mitochondria, accelerate senescence, and trigger systemic inflammation. You’ll learn how to reverse this damage, support cellular repair, and choose smarter formulations that...

Most supplements don’t work, and this episode reveals why. You’ll learn how to stop wasting money on “expensive pee,” how to spot marketing lies on labels, and which ingredients actually move the needle for energy, focus, and longevity.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Host Dave Asprey sits down with Jeff Boyd, f...

Psychedelic therapy is on the verge of reshaping mental health, trauma healing, and human consciousness. This episode reveals what’s really happening behind the scenes at the FDA, inside pharmaceutical companies, and within the global movement to legalize MDMA-assisted therapy.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Ho...