The Human Upgrade: Biohacking for Longevity & Performance

Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom.  This episode covers:   •  Apple Cider Vinegar Myth Busted   A weight-loss study just got retracted. ACV will not melt fat, but it may blunt glucose spikes or ease digestion when diluted in water before carb-heavy meals...

Gravity may be the most ignored signal in human biology, and it could be the missing key to unlocking fat loss, brain optimization, and true longevity. In this episode, you’ll learn how Earth’s pull shapes your metabolism, mood, and resilience, and discover practical hacks to fight “gravity intolerance” so you can perform better, live longer, and upgrade every system in your body.  Watch this...

Most people chase fat loss, focus, and energy with caffeine or stimulants, but the real key to brain optimization and human performance is a pharmaceutical nootropic that activates your wakefulness circuits without jitters or a crash. In this episode, you’ll learn how Modafinil upgrades mitochondria, sharpens neuroplasticity, improves metabolism, and extends longevity with evidence-based tools use...

Most people are struggling with fat loss, low energy, and hormone chaos—and they don’t even realize the real problem isn’t their diet or workout plan... it’s their liver. In this episode, I break down how your liver controls fat-burning, energy, and hormone regulation—and why things like poor bile flow and mineral deficiencies are sabotaging your results. I’ll show you how to fix your metabolism b...

Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts.  This episode covers:  - Rapamycin’s Reality Check:   A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adu...

Your mitochondria are the power plants of your cells, and when they break down, you lose energy, brain sharpness, and resilience against aging. In this episode, you’ll learn how to hack your mitochondria to supercharge human performance, prevent decline, and extend longevity with tools that are natural, effective, and backed by decades of research.  Watch the condensed video highlight version...

Your brain isn’t as rational as you think, and that blind spot can wreck your decision-making, relationships, and even your health. In this episode, you’ll learn how to spot the hidden cognitive traps that even the smartest people fall for, and how to upgrade your thinking so you can perform better, live longer, and make choices that actually serve you.  Watch the condensed video highlight ve...

If you feel like your brain's stuck in first gear, losing focus, forgetting simple things, feeling mentally sluggish—you’re not alone. I lived with brain fog for 15 years while building companies in Silicon Valley, and no productivity hack or double espresso fixed it. In this episode, I’ll show you how to clear brain fog at the cellular level by restoring mitochondrial energy, ditching brain-damag...

Confidence is biology you can hack. In this episode, you’ll see how confidence builds inside your brain, rewires through neuroplasticity, and connects directly to mitochondria, metabolism, and human performance. You’ll get tools that reprogram fear, regulate your nervous system, and turn stress into fuel so you build radical confidence that lasts.  Listen to this classic with host Dave Asprey...

If you’ve ever cringed at the sound of your own voice or struggled to hold attention in a room, this episode will change the way you speak and how others respond to you. You’ll discover how vocal tone, breath, and emotion act as biological levers you can train to improve your health, extend your longevity, and build magnetic charisma.  Watch the condensed video highlight version of this episo...

If you’ve ever felt crushed by stress or trapped by fear, this episode gives you the science and strategies to break free. You’ll learn how Olympic-level coaching can rewire your brain for resilience, unlock peak human performance, and extend your longevity through proven biohacking tools.  Watch the video highlight version of this episode (and much more!) on YouTube:  https://www.youtub...

Most men think declining testosterone is just “part of aging”, but that’s a lie Big Pharma sold you. In this video, I break down exactly how I raised my testosterone in my 50s without injections, drugs, or TRT. These are the same biohacks I used to turn my energy, drive, and strength around, naturally. I’ll walk you through how your diet, your sleep, and even the light in your bedroom could be sab...

Want to biohack your biology with nature’s most powerful anti-aging compounds? In this episode, you’ll discover how medicinal mushrooms fuel neurogenesis, protect mitochondria, supercharge immunity, and even help save the planet’s pollinators. From sharper focus and deeper REM sleep to protecting DNA from oxidative stress, fungi are the ultimate biohacking tools for performance, resilience, and lo...

Want to improve memory, unlock neuroplasticity, and achieve sharper brain optimization? This episode reveals how Transcendental Meditation (TM) functions as one of the most powerful nootropics for human performance, longevity, and resilience.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Host Dave Asprey sits down with neuros...

Most people spend their lives trying to outrun death instead of learning from it. This episode shows you why facing mortality directly can unlock resilience, forgiveness, gratitude, and peace while upgrading longevity, human performance, and even brain optimization.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Host Dave Aspr...

What if the foods you think are healthy are actually disrupting your biology? From sugar marketed as a performance tool to “whole grains” that drive cravings, this episode uncovers how hidden traps in modern nutrition can hijack your brain, wreck your metabolism, and accelerate aging. You’ll learn how to rethink daily eating so it fuels energy, resilience, and long-term health instead of quietly s...

Most people think broccoli is a superfood, but the reality is more nuanced. In this episode of The Human Upgrade , Host Dave Asprey explores the good and bad of broccoli—why adult broccoli can block thyroid function and cause gut issues, while broccoli seeds deliver sulforaphane, the powerful compound that activates all three of your body’s detox pathways. You’ll learn how sulforaphane protects ag...

Millions of people are living with unexplained symptoms like allergies, brain fog, anxiety, and chronic fatigue without realizing the hidden cause: mast cells gone rogue. In this episode of The Human Upgrade , Host Dave Asprey sits down with leading functional medicine physician Dr. Tania Dempsey to uncover how Mast Cell Activation Syndrome (MCAS) drives inflammation, disrupts mitochondria, and sa...

Most people track glucose or ketones, but almost no one is measuring the hidden signal that could be silently wrecking your metabolism, brain function, and longevity: uric acid. This episode reveals why this overlooked biomarker drives obesity, diabetes, cardiovascular disease, Alzheimer’s, and even accelerated aging—and how you can hack it to unlock resilience, human performance, and smarter not...

Your dopamine system is being hijacked every day, and the way to reclaim it might surprise you. This episode reveals how pain, pleasure, and addiction are wired in your brain, and how to use that knowledge for real brain optimization, resilience, and longevity. You’ll discover why your dopamine levels control motivation, focus, mood, and even cravings—and the science-backed strategies that reset y...

Alzheimer’s is not inevitable—and it may even be optional. In this groundbreaking episode, you’ll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Host Dave Asprey is joined by...

Your hormones may be waging a hidden war that determines how long you live and how well you perform. This episode reveals how male and female biology diverge—and what those differences mean for your longevity, metabolism, and brain optimization.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Revisit this episode where Dave Asp...

Walking speed predicts your risk of death better than cholesterol—and this episode reveals why. You’ll learn how to test your biological age at home in just 10 seconds, and how to use that information to upgrade your human performance, extend your longevity, and tailor your biohacking strategy for maximum results. Discover the overlooked role of pelvic floor strength, glute activation, and neuromu...

Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. Thi...

How do you activate your body’s natural repair system? How can you hack stem cells for faster recovery, brain optimization, and peak human performance? This episode reveals how to trigger stem cell release, direct them to the right tissues, and stack biohacking tools for maximum regeneration. You’ll learn science-backed strategies for boosting mitochondria, enhancing neuroplasticity, and extending...