JAMA Clinical Reviews

IgA nephropathy is a chronic kidney disease involving deposition of IgA-containing immune complexes in the glomerulus, which often causes kidney failure within 10 to 20 years. Author Michelle Marie O'Shaughnessy, MB, BCh, BAO, MS, of Galway University joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the symptoms, risk factors, diagnosis, treatment, and prognosis of IgA nephropathy in ad...

Restless legs syndrome is a sleep-related neurologic disorder that causes an overwhelming urge to move the limbs, which can cause substantial sleep disturbance. Author John W. Winkelman, MD, PhD, of Harvard Medical School joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the symptoms, risk factors, diagnosis, and treatment of restless legs syndrome. Related Content: Restless Legs Syndrom...

Mifepristone used with misoprostol is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics, with controversy over its legal status and regulation by the US Food and Drug Administration (FDA). Author G. Caleb Alexander, MD, MS, from Johns Hopkins discusses this and more with JAMA Deputy Editor Joseph S. Ross, MD, MHS. Related Content: The U...

Incidence rates of gastric cancer in younger individuals are on the rise and gastric cancer is the fifth-leading cause of cancer-related deaths worldwide. JAMA Review author Haeseong Park, MD, MPH, from the Dana Farber Cancer Institute, discusses this and more with JAMA Senior Editor Karen Lasser, MD, MPH. Related Content: Gastric Cancer

JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA Clinical Reviews podcasts in 2025. Related Content: Managing Adverse Effects of Obesity Medications Diagnosis and Management of Hypothyroidism Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment Managing Adverse Effects of Incretin-Based Medications for Obesity H...

In this episode, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Medical News Director Jennifer Abbasi discuss the journal's inaugural Research of the Year roundup. Related Content: Research of the Year 2025

Obesity affects more than 1 billion people worldwide and is recognized by the World Health Organization as a chronic, relapsing disease. WHO recently published a guideline in JAMA on the use and indications of GLP-1 therapies for the treatment of #obesity in adults. Francesca Celletti, MD, PhD, and Ezekiel Emanuel, MD, PhD, join JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discus...

Head and neck cancer is the seventh most common cancer worldwide and is commonly associated with tobacco and alcohol use, or human papillomavirus (HPV) infection. Author Lara Dunn, MD, of Memorial Sloan Kettering Cancer Center joins JAMA Associate Editor Margaret Wheeler, MD, to discuss the epidemiology, risk factors, diagnosis, treatment, and prognosis of head and neck cancer. Related Content: He...

Allergic rhinitis affects about 1 in 6 US adults. A recent JAMA Insights summarizes evidence regarding the associations of climate change and air pollution with allergic rhinitis and sinusitis. The discussion includes prevention and management strategies. Coauthor Neelima Tummala, MD, joins JAMA Deputy Editor Mary McDermott, MD, to discuss. Related Content: Climate Change, Allergic Rhinitis, and S...

Clinicians should weigh benefits against risks when engaging patients in informed discussions about cannabis or cannabinoid use. Kevin Hill, MD, MHS, of Harvard Medical School joins JAMA Senior Editor Karen Lasser, MD, MPH, to discuss the current evidence about the therapeutic use of cannabis and cannabinoids in adults, potential harms, and evidence-based clinical guidance. Related Content: Therap...

Peripheral neuropathy affects approximately 1% of adults worldwide and can be associated with significant disability. Author Michelle Mauermann, MD, of the Mayo Clinic in Minnesota joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss diagnosis and optimal management of peripheral neuropathy. Related Content: Peripheral Neuropathy

Metabolic dysfunction-associated steatotic liver disease (MASLD), an increasingly prevalent condition among adults worldwide, is associated with liver-related complications, hepatocellular carcinoma, and certain extrahepatic cancers. Author Norbert Stefan, MD, from the University Hospital of Tübingen in Tübingen, Germany, discusses this and more with JAMA Deputy Editor Kristin Walter, MD, MS. Rela...

The JAMA Summit on Firearm Violence convened 60 thought leaders from a wide array of disciplines to chart a roadmap that could lead to substantial reductions in firearm harms by 2040. Frederick P. Rivara, MD, MPH, of the University of Washington joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss the Summit and steps that could lead to a safer world by 2040. Related Conten...

Keratinocyte carcinomas, which include basal cell carcinoma and squamous cell carcinoma, are common forms of skin cancer. Approximately 5.4 million keratinocyte carcinomas are diagnosed in the US annually. Author Mackenzie R. Wehner, MD, MPhil, of the University of Texas MD Anderson Cancer Center joins JAMA Associate Editor David Simel, MD, MHS, to discuss treatment of these types of nonmelanoma s...

Lung cancer in nonsmoking individuals is increasing worldwide and currently accounts for 15% to 20% of lung cancer cases globally. Benjamin Solomon, PhD, of the Peter MacCallum Cancer Centre in Melbourne, Australia, discusses the epidemiology and treatment of lung cancer in nonsmoking patients with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content: Lung Cancer in Nonsmoking Individuals --...

Syphilis infections have increased in the US and worldwide over the past decade. Left untreated, syphilis can cause blindness, deafness, psychosis, dementia, and peripheral nerve damage, and can cause congenital syphilis. Author Franco Chevalier, MD, MPH, from the San Francisco Department of Public Health discusses this and more with JAMA Deputy Editor Preeti Malani, MD, MSJ. Related Content: Syph...

Microplastics, defined as plastics smaller than 5 mm, have been detected in human tissues at increasing rates and are associated with potential adverse health effects. Author David Christiani, MD, MPH, from the Department of Environmental Health at Harvard T.H. Chan School of Public Health, discusses this topic and more with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content: Microplastics...

Severe refractory asthma, which affects approximately 1% to 5% of patients with asthma, is associated with increased morbidity and mortality. Author Juan Carlos Cardet, MD, MPH, of the University of South Florida joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the management of patients with severe refractory asthma, including first-line medications and biologics. Related Content: Mana...

Epidemiologist Brian Lee, PhD, discusses his study on acetaminophen use during pregnancy and children's risk of autism and other neurodevelopmental disorders in this interview with JAMA Deputy Editor Linda Brubaker, MD. Related Content: Acetaminophen Use in Pregnancy—Study Author Explains the Data ----------------------------------- JAMA Editors' Summary

Health care professionals often use numbers to guide decisions, monitor patient health, and communicate information. Author Angela Fagerlin, PhD, of the University of Utah joins JAMA Senior Editor Anne Cappola, MD, ScM, to discuss how providing numerical information may be helpful in shared decision-making with patients. Related Content: How to Communicate Medical Numbers -------------------------...

Superficial vein thrombosis (SuVT) is characterized by thrombus formation in the superficial veins, typically in the lower or upper extremities. In this podcast, the coauthor of a JAMA review on SuVT, Behnood Bikdeli, MD, MS, discusses pathophysiology, risk factors, diagnosis, and treatment of SuVT with JAMA Deputy Editor Mary McDermott, MD. Related Content: Superficial Vein Thrombosis -----------...

Untreated hypothyroidism can cause serious health complications such as heart failure and myxedema coma. Author Maria Papaleontiou, MD, of the University of Michigan joins JAMA Senior Editor Karen Lasser, MD, MPH, to discuss the current evidence regarding the epidemiology, diagnosis, clinical presentation, and treatment of primary overt hypothyroidism in nonpregnant adults. Related Content: Hypoth...

Interview with Alexander Chern, MD, author of Over-the-Counter Hearing Aid–Enabled Earbuds—Merging Hearing Health and Technology. Hosted by Paul C. Bryson, MD, MBA. Related Content: Over-the-Counter Hearing Aid–Enabled Earbuds—Merging Hearing Health and Technology ----------------------------------- JAMA Editors' Summary

The incidence and prevalence of cutaneous melanoma in the US and worldwide have increased over the last 5 decades. JAMA Review Author John Kirkwood, MD, discusses the epidemiology, risk factors, treatment, and prevention of melanoma with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content: Cutaneous Melanoma ----------------------------------- JAMA Editors' Summary

Hemorrhoidal disease, pathology of the tissue lining the anal canal, affects approximately 10 million individuals in the US. Author Jean H. Ashburn, MD, of Wake Forest University School of Medicine and JAMA Senior Editor Karen E. Lasser, MD, MPH, discuss the current evidence on the epidemiology, pathophysiology, diagnosis, and treatment of hemorrhoidal disease. Related Content: Hemorrhoidal Diseas...