NEJM This Week

This week, we feature new research on transcatheter treatment for tricuspid regurgitation, multicancer early-detection testing, resuscitation strategies for septic shock, and an experimental approach to restoring vision. We review advances in breast cancer treatment, follow a puzzling case of prolonged fever and lymphadenopathy, and report on scientific reproducibility. Perspectives discuss outbre...

This week, we feature new research on statin therapy in older adults, treatments for IgG4-related disease and advanced breast cancer, and a once-weekly oral regimen for HIV. We review Andes virus and follow a challenging case of a disseminated infection. Articles explore scientific independence, opioid-settlement funds, pharmaceutical policy, and the role of community in patient care.

This week, we feature new research on anticoagulation for atrial fibrillation, treatment for narcolepsy, and gene and cell therapies for multiple myeloma and Wiskott–Aldrich syndrome. We review the clinical use of common genetic variants and follow a case of a young child with fatigue and frequent falls. Perspectives explore access to sickle cell therapies, child health, and biomedical science.

This week, we feature new research on colorectal cancer surveillance, metabolic acidosis in critical illness, pediatric leukemia, and food-allergy prevention. We also review esophageal cancer and follow a case of severe nutritional deficiency and memory loss. Perspectives address AI and the clinical workforce, physician staffing in the Indian Health Service, human trafficking and child health, and...

This week, we feature new research on gene-edited therapies for children with β-thalassemia and sickle cell disease, treatment for membranous nephropathy, coronary revascularization after myocardial infarction, and an outbreak of severe methemoglobinemia. We review treatment decisions in multiple myeloma, follow a case of man with fever and rash, and report on psychedelic drug development. Perspec...

This week, we feature new research on acute myeloid leukemia, achondroplasia, pediatric septic shock, and RAS-mutant lung cancer. We also review the evaluation and management of pulmonary nodules and follow a diagnostic case of recurrent fractures. Perspectives explore reproductive health care, the human–animal bond in health care access, and on creating space for patients’ voices in clinical deci...

This week, we feature new research on acute respiratory failure, wheezing in childhood, lung cancer, and obesity. We review myeloproliferative neoplasms and follow a diagnostic case of a patient with myasthenia gravis who developed dyspnea and weakness. Perspectives explore medical marijuana research, AI in clinical care, sexual and gender minority health research, and the Perspectives Editor sayi...

This week, we feature new research on polymyalgia rheumatica, hypercholesterolemia, prostate cancer, and multiple myeloma. We review evidence-based strategies for tobacco cessation, and follow a case of a woman with nausea, dizziness, and metabolic acidosis. We discuss recent advances in gene editing for rare metabolic diseases. Perspectives address HIV care, health care quality, medical ethics, a...

This week, we feature new research on chronic kidney disease, high-risk prostate cancer, peripheral artery disease, and oxygen therapy after cardiac arrest. We review the evaluation and management of syncope, follow a challenging case of immune-related inflammatory illness, and report on Perspectives exploring pandemic preparedness, the Bundibugyo Ebola outbreak, and physician mental health.

This week, we feature advances that may change care for prostate cancer, multiple myeloma, acute pain, and IgA nephropathy. We review platelet factor 4 disorders and follow a case of persistent nasal ulceration. Perspectives explore medical aid in dying, federal authority in health care, public health and litigation, and the challenge of delivering life-changing news with honesty and compassion.

This week, we bring you advances in pancreatic and bladder cancer, preventing gonorrhea, a promising new therapy for adolescent hypertrophic cardiomyopathy, and a review of antiretroviral treatment for HIV. We also follow a striking case of vision loss that led to an unexpected diagnosis and discuss Perspectives on vaccine evidence, hepatitis C elimination, the endorsements of prescription drugs o...

This week, we present advances in the treatment of multiple myeloma, systemic lupus erythematosus, and coronary artery disease, alongside new national data on health care–associated infections. We also review fibromyalgia and the emerging Bundibugyo virus outbreak, follow a surprising diagnostic case of alpha-gal syndrome, and explore Perspectives on caring for vulnerable patients, trustworthy hea...

This week, we present advances in the treatment of idiopathic pulmonary fibrosis, hypothalamic obesity, and lung cancer. We review nutrition in critical illness and follow a diagnostic case involving a patient who had a lung transplant. The Editors warn about the politicization of science. We discuss the dead donor rule in an era of voluntary euthanasia. Perspectives explore the forthcoming crisis...

This week, we discuss less-invasive approaches to guiding coronary intervention, new strategies for preventing kidney cancer recurrence, and head-to-head treatment data in multiple sclerosis. We review advances in multiple sclerosis, follow a diagnostic journey involving gait instability, and discuss correcting false narratives. Perspectives examine physicians and the body politic, chronic pain an...

This week, we discuss a promising step toward a functional cure for chronic hepatitis B, first-line pulsed field ablation for persistent atrial fibrillation, reducing the demand for transfusion in surgery, treatment for rifampicin-resistant tuberculosis, and a decade-long look at CAR T-cell therapy outcomes. We review peanut allergy and discuss a case of a man with leg weakness, pain, and weight l...

This week, we discuss endovascular therapy for post-thrombotic syndrome, new evidence on prehospital blood transfusion strategies in trauma patients, and a trial of cefazolin for Staph. aureus bacteremia. We examine evolving approaches to thyroid cancer and share a case of a man with pancytopenia after heart transplantation. Perspectives explore psychedelic therapy, the convergence of Down syndrom...

This week, we present new evidence guiding coronary intervention, a molecular mechanism of inflammatory bowel disease, and gene therapy for a recessive disease. We review antidotes for anticoagulation reversal and discuss a case of hypertension in an adolescent patient. Perspectives examine cholera control, gambling-related harms, and race-based prescribing, alongside a reflection on medicine, mot...

This week, we discuss left atrial appendage closure for atrial fibrillation, oxygen strategies in respiratory failure, an all-oral treatment for acute myeloid leukemia, CAR T-cell therapy enabling kidney transplantation, and a case of a neuroepithelial tumor that developed after gene therapy. We review childhood vaccine hesitancy, follow a complex diagnostic case, and examine Perspectives on corpo...

This week, we present new research guiding treatment of pulmonary embolism, early progress in cardiac regeneration with engineered heart tissue, and treatments for gastroesophageal cancer and Chiari malformation. We review leishmaniasis and follow a revealing neurologic case. Perspectives discuss nutrition policy, tickborne illness, structural competence in medicine, and the arrival of closure.

This week, we present a promising new therapy for dermatomyositis, evolving approaches to stroke care, the prevention of Covid-19 after household exposure, and new treatments for kidney disease. We review inflammatory myopathies and follow a complex case of multisystem illness. Perspectives discuss AI and uncertainty in clinical care, health equity, the forces shaping affordability in health care,...

This week, we present research on high-risk coronary intervention strategies, targeted therapy for pancreatic cancer, an mRNA influenza vaccine, and treatments for severe scabies and sickle cell disease. We review cerebral amyloid angiopathy and follow a complex case of a disseminated infection. Perspectives address the impact of corporate medicine on medical training and drug pricing policy.

This week, we feature advances in targeted therapy for HER2-mutant lung cancer, interventions to reduce maternal infection, an emerging treatment for hemophilia A, and a new diagnostic test for tuberculosis. We review Barrett’s esophagus and follow a case of systemic illness with kidney failure. Perspectives address GLP-1 drugs and eating disorders, directed blood donation, generic drug safety, an...

This week, we explore new strategies for blood-pressure control after intracerebral hemorrhage, Covid-19 treatment in higher-risk patients, hormonal therapy for prostate cancer, and anesthesia for tracheal intubation. We review spinal epidural abscess and follow a case of progressive weakness and liver lesions. We examine advances in tRNA research, and Perspectives discuss the use AI in prescribin...

This week, we present new research on stroke prevention, Kawasaki disease, ICU infection strategies, and immune thrombocytopenia. We review hormone therapy and thrombotic risk. A case highlights an evolving diagnosis of severe fatigue and sleep disturbance. Perspectives explore nursing workforce policy, the role of nurse scientists in rebuilding trust, and the health consequences of environmental...

This week, we present new research on intensive LDL cholesterol targets, team-based strategies to improve blood pressure control, emerging therapies for immune and oncologic diseases, and a next-generation yellow fever vaccine. We review celiac disease and follow a compelling case of post-procedural complications. Perspectives explore health disparities and efforts to strengthen care in vulnerable...