Blood Podcast

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Dan Chalothorn and David Gutstein from Regeneron Pharmaceuticals, and Dr. Ajitha Thanabalasuriar from McGill University on their latest articles published in Blood . The first half of the episode features " Anticoagulation with the mechanistically distinct FXI/FXIa antibodies amrecibart (REGN9933 A2 ) and cenvacibart (REGN7508 Ca...

In this week's episode, Blood editor Dr. Laura Michaelis interviews Dr. Harry Erba of Duke University and Dr. Sairah Ahmed of the University of Texas MD Anderson Cancer Center on their latest articles published in Blood on durable treatment strategies for relapsed and refractory hematologic malignancies. Dr. Erba discusses " Ziftomenib with venetoclax and azacitidine for relapsed/refractory NPM1-m...

In this week's episode, Blood editor Dr. James Griffin interviews Dr. Jianxiang Wang from the National Clinical Research Center for Blood Diseases and the Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College in Tianjin, China, on his latest article published in Blood titled " Venetoclax plus pediatric regimen in adolescents and...

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Mariateresa Fulciniti and Angelo D'Alessandro on their latest articles published in Blood . Dr. Fulciniti, of the Dana Farber Cancer Institute, discusses the development of " PKMYT1 is a targetable vulnerability in del(17p) high-risk multiple myeloma " starting from the question, "Is 17P loss simply a prognostic marker, or does i...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Thomas Milne and Dominique Bonnet on their latest articles published in volume 147 issue 24 of Blood . Dr. Milne discusses how transcription factors simultaneously activate enhancers and connect them to their target genes in KMT2A-rearranged acute lymphoblastic leukemia. The binding of MYB, a key hematopoietic TF, is sufficient...

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Camille Laurent and Christine Bezombes on their latest article published in Blood titled " Patient-derived lymphoma spheroids reveal predictive markers of glofitamab resistance in relapsed/refractory B-NHL ." By using patient-derived lymphoma spheroids as an ex vivo platform, they identify key mechanisms of resistance to the bisp...

In this week's episode, Blood editor Laurie Sehn interviews Drs. Efstathios Kastritis and Lucia Chen on their latest articles published in Blood . Dr. Kastritis shares insights and results from the final survival analysis of the ANDROMEDA trial, which determined that adding daratumumab to cyclophosphamide, bortezomib, and dexamethasone improves hematologic responses and overall survival in newly d...

In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs. Joshua Hill and Jeffery Weitz on their latest articles published in Blood . Dr. Hill and Dr. Michaelis discuss the evolving landscape of infection risk in adults receiving bispecific antibody therapies for advanced B‑cell malignancies. They explore how these risks differ from those seen with allogeneic transplant, CAR T‑cell...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. George Goshua, Gerd Blobel, and Paul Kaminski on their latest articles published in Blood . Dr. Goshua elaborates on the background and then insights from " Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis ". This analysis provides valuable guidance for clinicians,...

In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs. Matthew Frank and Jieqing Zhu on their latest articles published in volume 147 issue 22 of Blood . Dr. Frank discusses " How I treat HLH-like toxicities after immune effector cell therapy ", in which the two cases presented emphasize the need for early identification, the use of anticytokine therapy with either emapalumab or...

In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs. Pierre-Yves Dumas and Samik Basu on their latest articles published in Blood . Dr. Dumas talks about " Prognostic impact of FLT3-ITD microclones in young adults with acute myeloid leukemia treated with intensive chemotherapy " where the team was able to identify that ultra-low-burden FLT3-ITD microclones are associated with h...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Hanny Al-Samkari and Xin Zhou on their latest articles published in Blood . This episode highlights two important advances in hematology: the first report from the CHORUS registry for hereditary hemorrhagic telangiectasia (HHT) presented by Dr. Al-Samkari and also the introduction of the ASH Hematomics (ASHOP) platform for inte...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Haris Sohail and Lucas Kühne on their latest articles published in volume 147 issue 21 of Blood . In this CME article titled, " Retrospective, Real-World Study of IV Iron Use to Treat Iron deficiency Anemia During Acute Infection ",  Sohail et al show that IV iron given during acute infection with iron deficiency anemia is asso...

In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs. Kirsty Hillier and Marco Ruella on their latest articles published in Blood . For " Predicting Development of Pediatric Chronic Immune Thrombocytopenia at Disease Onset Using a Statistical Risk Model ", Dr. Hillier shares the potential benefits of incorporating this new model to enhance the care of the 1 in 4 patients who dev...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Heinz Zoller and Raul Ribeiro on their latest articles published in Blood . Dr. Zoller discusses " Ferric Carboxymaltose Increases Fracture Risk in Patients and Reduces Bone Formation in Mice with Iron Deficiency Anemia ", and how these findings support consideration of alternative IV iron formulations that provide similar effi...

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Everett Meyer and Olivier Hermine on their latest articles published in volume 147 issue 11 of Blood . Dr. Everett Meyer discusses " Orca-T vs allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial " which demonstrated that Orca-T showed superior chronic GVHD–free survival compar...

In this episode, Blood editor Dr. Laura Michaelis interviews Drs. Nigel Russell and Uwe Platzbecker on their articles published in volume 147 issue 10 of Blood . Dr. Russell discuses " CPX-351 vs daunorubicin, cytarabine, and gemtuzumab ozogamicin in older adults with non–adverse-risk AML: the NCRI AML18 trial " where a large randomized trial demonstrated that DA-GO2 provided greater overall survi...

In this week's episode, Blood editor Dr. Philippe Armand interviews Drs. Manali Kamdar and Nancy L. Bartlett on their latest review article published in Blood titled “ From breakthroughs to blueprints: evolving evidence and future directions in relapsed and refractory large B-cell lymphoma ”. They discuss the how the advent of chimeric antigen receptor T cells, antibody-drug conjugates, and bispec...

In this Review series episode, Blood associate editor Dr. Diane Krause interviews contributing authors from the Review Series on Clonal tracking in Hematopoiesis published in volume 147 issue 23 of Blood . Dr. Alejo E. Rodriguez-Fraticelli speaks to the development of his paper, " Clonal tracing of blood stem cells across mouse and human lifespans ”, which provides a detailed overview of the exper...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Johnny Mahlangu and Joseph Rocco on their articles published in volume 147 issue 9 of Blood .  Dr. Mahlangu discusses study details and next steps from " Efficacy and safety of marstacimab prophylaxis in hemophilia A/B with inhibitors: results from the phase 3 BASIS trial " which shows that bleeding was reduced by 93% with subc...

 In this episode, Blood deputy editor Dr. Helen Heslop interviews contributing  authors from the Blood review series on hemophagocytic lymphohistiocytosis . Drs. Nancy Berliner and Joanne Hsu join to provide insight on their paper, “ Hemophagocytic lymphohistiocytosis in adults ” discussing the importance of prompt diagnosis and treatment in this high-mortality disorder, and highlight emerging age...

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Reuben Kapur and Robert Campbell on their latest articles published in Blood . This episode highlights two groundbreaking studies exploring how inflammation drives serious blood and immune-related diseases. In the first interview, Dr. Kapur discusses how inflammatory bowel disease (IBD) can both promote and worsen clonal hematopo...

In this week's episode, Blood editor Dr. Laura Michaelis interviews Dr. Alexis Thompson, former ASH president, on her latest article published in Blood . Dr. Thompson discusses " Long-term efficacy and safety results of betibeglogene autotemcel gene therapy for transfusion-dependent β-thalassemia ." She explains transfusion-dependent β-thalassemia (TDT) requires rigorous, lifelong transfusion ther...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Francesco Forconi and Bin Guo on their latest articles published in Blood. Dr. Guo shares insights from " Nucleoplasmic ZNF467 condensates boost hematopoietic stem cell engraftment via ICAM1-mediated mechanical reprogramming ". The findings establish biomechanical regulation as an important determinant of stem cell identity and...

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Shengwen Calvin Li and Hrishi Krishna Srinagesh on their latest articles published in Blood . Dr. Li discusses " Single-cell profiling of ANKRD26 thrombocytopenia reveals progenitor expansion and polyploid apoptosis via JUNB-p21 ". The study identifies reproducible abnormalities in progenitor expansion and increased apoptosis of...