Blood Podcast

In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs. Kirsty Hillier and Marco Ruella on their latest articles published in Blood . For " Predicting Development of Pediatric Chronic Immune Thrombocytopenia at Disease Onset Using a Statistical Risk Model ", Dr. Hillier shares the potential benefits of incorporating this new model to enhance the care of the 1 in 4 patients who dev...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Heinz Zoller and Raul Ribeiro on their latest articles published in Blood . Dr. Zoller discusses " Ferric Carboxymaltose Increases Fracture Risk in Patients and Reduces Bone Formation in Mice with Iron Deficiency Anemia ", and how these findings support consideration of alternative IV iron formulations that provide similar effi...

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Everett Meyer and Olivier Hermine on their latest articles published in volume 147 issue 11 of Blood . Dr. Everett Meyer discusses " Orca-T vs allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial " which demonstrated that Orca-T showed superior chronic GVHD–free survival compar...

In this episode, Blood editor Dr. Laura Michaelis interviews Drs. Nigel Russell and Uwe Platzbecker on their articles published in volume 147 issue 10 of Blood . Dr. Russell discuses " CPX-351 vs daunorubicin, cytarabine, and gemtuzumab ozogamicin in older adults with non–adverse-risk AML: the NCRI AML18 trial " where a large randomized trial demonstrated that DA-GO2 provided greater overall survi...

In this week's episode, Blood editor Dr. Philippe Armand interviews Drs. Manali Kamdar and Nancy L. Bartlett on their latest review article published in Blood titled “ From breakthroughs to blueprints: evolving evidence and future directions in relapsed and refractory large B-cell lymphoma ”. They discuss the how the advent of chimeric antigen receptor T cells, antibody-drug conjugates, and bispec...

In this Review series episode, Blood associate editor Dr. Diane Krause interviews contributing authors from the Review Series on Clonal tracking in Hematopoiesis published in volume 147 issue 23 of Blood . Dr. Alejo E. Rodriguez-Fraticelli speaks to the development of his paper, " Clonal tracing of blood stem cells across mouse and human lifespans ”, which provides a detailed overview of the exper...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Johnny Mahlangu and Joseph Rocco on their articles published in volume 147 issue 9 of Blood .  Dr. Mahlangu discusses study details and next steps from " Efficacy and safety of marstacimab prophylaxis in hemophilia A/B with inhibitors: results from the phase 3 BASIS trial " which shows that bleeding was reduced by 93% with subc...

 In this episode, Blood deputy editor Dr. Helen Heslop interviews contributing  authors from the Blood review series on hemophagocytic lymphohistiocytosis . Drs. Nancy Berliner and Joanne Hsu join to provide insight on their paper, “ Hemophagocytic lymphohistiocytosis in adults ” discussing the importance of prompt diagnosis and treatment in this high-mortality disorder, and highlight emerging age...

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Reuben Kapur and Robert Campbell on their latest articles published in Blood . This episode highlights two groundbreaking studies exploring how inflammation drives serious blood and immune-related diseases. In the first interview, Dr. Kapur discusses how inflammatory bowel disease (IBD) can both promote and worsen clonal hematopo...

In this week's episode, Blood editor Dr. Laura Michaelis interviews Dr. Alexis Thompson, former ASH president, on her latest article published in Blood . Dr. Thompson discusses " Long-term efficacy and safety results of betibeglogene autotemcel gene therapy for transfusion-dependent β-thalassemia ." She explains transfusion-dependent β-thalassemia (TDT) requires rigorous, lifelong transfusion ther...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Francesco Forconi and Bin Guo on their latest articles published in Blood. Dr. Guo shares insights from " Nucleoplasmic ZNF467 condensates boost hematopoietic stem cell engraftment via ICAM1-mediated mechanical reprogramming ". The findings establish biomechanical regulation as an important determinant of stem cell identity and...

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Shengwen Calvin Li and Hrishi Krishna Srinagesh on their latest articles published in Blood . Dr. Li discusses " Single-cell profiling of ANKRD26 thrombocytopenia reveals progenitor expansion and polyploid apoptosis via JUNB-p21 ". The study identifies reproducible abnormalities in progenitor expansion and increased apoptosis of...

In this week's episode, Blood podcast editor Laurie Sehn interviews Drs. Edward Cliff on his latest research published in volume 147 issue 14 of Blood . Dr. Cliff discusses " Global access to commercial CAR T-cell therapies: a cross-sectional study of health technology assessment across the G20 countries " which maps the mismatch between innovation and implementation across high-income and selecte...

In this week's episode, Blood podcast editor Dr. James Griffin interviews authors Drs. Steffen Boettcher and Robert Zeiser on their recent publications in Blood . Dr. Boettcher discusses " Bone marrow failure, somatic rescue by p53 inactivation, and enhanced leukemogenesis in germ line ERCC6L2 disease ", which provides insights to disease evolution by demonstrating that p53 loss can rescue BMF phe...

In this episode, Blood Associate Editor Dr. Jason Gotlib discusses the Review Series " The New Wave of Targeted Therapeutics for MPN’s ", with authors Drs. Stefan Constantinescu, Ann Mullally, and Marina Kremyanskaya. This Review Series covers 3 areas where exciting advances are occurring. Dr. Constantinescu discusses “ Next-generation JAK inhibitors in the treatment of myeloproliferative neoplasm...

In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs. Alexander Bick and Jorge Cortes on their latest papers published in Blood . Dr. Cortes, the current EIC of Blood Global Hematology discusses " Asciminib Demonstrates Superior Efficacy and Safety in Newly Diagnosed Chronic Myeloid Leukemia in the ASC4FIRST Trial " wherein the planned secondary analysis showed a further efficac...

In this week's episode of the Blood podcast, editor Dr. James Griffin interviews Drs. Christian Gorzelanny and Rebecca Leaf on their latest articles published in this week's issue of Blood . Dr. Gorzelanny discusses compelling evidence for a new mechanism that amplifies their proinflammatory actions in " Lipid nanotubes unmask neutrophils for complement attack ", demonstrating the pathological rol...

In this week's episode, Blood editor Dr. Laura Michaelis interviews authors Drs. Marion Falabrègue and Ajai Chari on their papers published in volume 146 issue 24 of Blood . The work of Dr. Falabrègue and colleagues in " Intestinal hepcidin overexpression promotes iron deficiency anemia and counteracts iron overload via DMT1 downregulation " indicates that iron absorption from the apical surface o...

In this week's episode, Blood associate editor Dr. Laura Michaelis interviews Drs. Mark Sorial and Emmanuelle Passegue on their articles published in volume 147 issue 7 of Blood . Dr. Sorial discusses " Early time to relapse as a survival prognosticator in nodal mature T-cell lymphomas: results from the PETAL consortium " where he and his team evaluated the prognostic significance of early relapse...

This review series focuses on recent advances in resolving macro and molecular structures that have driven the field of occlusive thrombus structure and function forward. Covering multiple contributions to thrombosis, eg, platelets, factor XIII, and the contact system, the series also looks to put this new knowledge into the context of future advances in diagnostic and therapeutic tools to enhance...

In this week's episode, Blood editor Dr. Laurie Sehn interviews authors Drs. Julie Jaffray and Ulrike Philippar on their latest articles published in Blood . Dr. Jaffray discusses her CME article, " Multisite validation of a venous thrombosis risk model in critically ill children through the CHAT Consortium ", identifying patients with risks as high as 17% and taking research one step closer to th...

In this week's episode, Blood editor Dr. Laurie Sehn interviews authors Drs. Anastasios Karadimitris and Maria Carolina Florian on their papers published in Volume 147 Issue 2 of Blood . Dr. Karadimitris' paper " Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A -rearranged leukemia ", discusses the success of bispecific CAR-iNKT cells targeting...

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Paresh Vyas and Andrew Hantel on their research published in this week's issue of Blood . Dr. Vyas discusses his paper, " Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy ", which provided new insights as to when and how to intervene to circumvent resistance...

In this week's episode, Blood Associate editor Dr. Hervé Dombret interviews authors Drs. Sarah K. Tasian and David T. Teachey on their contributions to the How I Treat Series on acute lymphoblastic leukemia. Dr. Tasian's paper, “ How I treat Philadelphia chromosome-like acute lymphoblastic leukemia in children, adolescents, and young adults ” discusses the different classes of Ph-like ALL and revi...

In this week's episode, Blood Associate Editor, Dr. Jason Gotlib leads a discussion about the How I Treat Series commemorating the 25th anniversary of the introduction of tyrosine kinase inhibitors in CML, featuring Drs. Neil Shah, Simona Soverini, Elisabetta Abruzzese, and Yves Chalandon. The introduction of TKIs revolutionized patient outcomes in CML, turning a poor prognosis—3 to 5 years life e...