Maddy Chang McDonough
Vector Signals
A private, AI-curated podcast delivering 15-20 minute deep dives into the latest Nature articles on mosquito-borne viruses and AI-driven therapeutic breakthroughs. Designed for the researchers of the Saleh Lab at Institut Pasteur, each episode distills cutting-edge science into accessible insights—so you can stay current, even during your busiest bench days.
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Episodes
Tiger Mosquito Larvae Exhibit Consistent Individual Personality (November 2025) 17.11.2025 10:35
Briefing Document: Personality Traits in the Tiger Mosquito, Aedes albopictus Source: Cordeschi, G., Mastrantonio, V., De Nicola, C. et al. Insect vectors have personality: first evidence with the tiger mosquito Aedes albopictus . Sci Rep 15 , 39943 (2025). https://doi.org/10.1038/s41598-025-23665-w Date: Received - 16 June 2025 | Accepted - 08 October 2025 | Published - 14 November 2025 Executive...
Predicting Dengue Risk with Machine Learning and Microclimate Data (October 2025) 24.10.2025 12:36
Briefing: Fine-Scale Predictive Modeling for Dengue Risk in Malaysia Source: Dom, N.C., Abdullah, N.A.M.H., Dapari, R. et al. Fine-scale predictive modeling of Aedes mosquito abundance and dengue risk indicators using machine learning algorithms with microclimatic variables. Sci Rep 15 , 37017 (2025). https://doi.org/10.1038/s41598-025-17191-y Date: Received - 01 February 2025 | Accepted - 21 Augu...
Medfly Gut Microbiota and Insecticide Resistance (September 2025) 01.10.2025 13:16
Gut Microbiota and Insecticide Resistance in the Mediterranean Fruit Fly ( Ceratitis capitata ) Source: Charaabi, K., Hamdene, H., Djobbi, W. et al. Assessing gut microbiota diversity and functional potential in resistant and susceptible strains of the mediterranean fruit fly. Sci Rep 15 , 33456 (2025). https://doi.org/10.1038/s41598-025-01534-w Dates: Received - 06 November 2024 | Accepted - 06 M...
Mosquito Diversity and Vector Distribution in Kerala, India (Aug 2025) 23.08.2025 14:02
Mosquito Diversity and Public Health Risk in Kerala, India: A Synthesis of a Multi-District Survey Source: Mathiarasan, L., Natarajan, R., Aswin, A. et al. Diversity and spatiotemporal distribution of mosquitoes (Diptera: Culicidae) with emphasis on disease vectors across agroecological areas of Kerala, India. Sci Rep 15 , 30603 (2025). https://doi.org/10.1038/s41598-025-16357-y Date: Received -...
AI and Electric Fields for Automated Insect Monitoring (Aug 2025) 16.08.2025 19:23
Briefing: Automated Insect Monitoring via AI and Electrical Field Sensors Source: Odgaard, F.B., Kjærbo, P.V., Poorjam, A.H. et al. Automated insect detection and biomass monitoring via AI and electrical field sensor technology. Sci Rep 15 , 29858 (2025). https://doi.org/10.1038/s41598-025-15613-5 Date: Received - 11 April 2025 | Accepted - 08 August 2025 | Published - 14 August 2025 Executive Sum...
Successive Feeding Impacts Wolbachia's Dengue Virus Inhibition in Aedes aegypti (July 2025) 29.07.2025 14:10
Impact of Mosquito Feeding Behavior on Wolbachia -Based Dengue Control Date: Received - 17 February 2025 | Accepted - 18 July 2025 | Published - 29 July 2025 Source: Johnson, R.M., Breban, M.I., Nolan, B.L. et al. Implications of successive blood feeding on Wolbachia -mediated dengue virus inhibition in Aedes aegypti mosquitoes. Nat Commun 16 , 6971 (2025). https://doi.org/10.1038/s41467-025-62352...
AI for Culex Mosquito Identification using Wing Patterns (July 2025) 01.07.2025 16:06
Detailed Briefing Document: Application of Wing Interference Patterns (WIPs) and Deep Learning (DL) for Culex spp. Classification Application of wings interferential patterns (WIPs) and deep learning (DL) to classify some Culex. spp (Culicidae) of medical or veterinary importance Arnaud Cannet, Camille Simon Chane, Aymeric Histace, Mohammad Akhoundi, Olivier Romain, Pierre Jacob, Darian Sereno, Ma...
Battle of the Mosquitoes: Genetic War on Malaria (June 2025) 27.06.2025 16:39
Detailed Briefing Document: The Battle of the Mosquitoes - A New Approach to Malaria Control Source: Adepoju, P. Battle of the mosquitoes. Nat Med 31 , 1722–1726 (2025). https://doi.org/10.1038/s41591-025-03753-0 Dates: Published - 11 June 2025 | Issue Date - June 2025 I. Executive Summary This briefing document summarizes the key themes and facts from the provided source, "Battle of the Mosquitoe...
Greenland Mosquito Virome: Arctic Aedes Uniqueness (May 2025) 30.05.2025 20:53
Briefing Document: Unique Virome of Arctic Mosquitoes in Greenland Source: https://doi.org/10.1038/s41598-025-01086-z : "Metagenomic analysis of mosquitoes from Kangerlussuaq, Greenland reveals a unique virome" by Schilling, Jagdev, Thomas, & Johnson (2025). Date: Received - 17 January 2025 | Accepted - 02 May 2025 | Published - 17 May 2025 Subject: Metagenomic analysis of mosquito viromes in...
Novel Quinolones Counteract Insecticide Resistance in Malaria Vectors (May 2025) 30.05.2025 24:59
BRIEFING DOCUMENT: Novel Approach to Malaria Control Targeting Mosquito-Stage Plasmodium Parasites Date: Received - 29 March 2025 | Accepted - 17 April 2025 | Published - 21 May 2025 Source: Excerpts from "In vivo screen of Plasmodium targets for mosquito-based malaria control" by Probst et al. (Published online xx xx xxxx, Nature) https://doi.org/10.1038/s41586-025-09039-2 Subject: Development an...
Blocking Malaria Transmission with PfPIMMS43 Nanobodies (April 2025) 03.05.2025 12:55
Briefing Document: Nanobody-Mediated Blocking of Malaria Transmission Targeting PfPIMMS43 Source: Excerpts from "s42003-025-08033-8.pdf" (A Nature Portfolio journal; https://doi.org/10.1038/s42003-025-08033-8 ) Authors: Chiamaka Valerie Ukegbu, et al. Date: Received - 04 December 2024 | Accepted - 02 April 2025 | Published - 30 April 2025 Executive Summary: This study explores a novel strategy to...
Nanofiber Encapsulation of Pseudomonas for Sustained Mosquito Larvicide Release (April 2025) 21.04.2025 13:42
Briefing Document: Nanofiber Encapsulation of Pseudomonas aeruginosa for Sustained Mosquito Larvicide Release Date: Received - 13 December 2024 | Accepted - 04 April 2025 | Published - 21 April 2025 Source: Excerpts from "Nanofiber encapsulation of Pseudomonas aeruginosa for the sustained release of mosquito larvicides" https://doi.org/10.1038/s41598-025-97400-w 1. Executive Summary: This study in...
Predicting Aedes Albopictus Spread in Europe via Climate and Population (April 2025) 11.04.2025 12:56
Population Dependent Diffusion Model for Aedes Albopictus Spread in Europe Source: Barman et al., "A climate and population dependent diffusion model forecasts the spread of Aedes Albopictus mosquitoes in Europe," Nature Portfolio journal , 2025, https://doi.org/10.1038/s43247-025-02199-z Date: Received - 25 November 2024 | Accepted - 07 March 2025 | Published - 09 April 2025 Key Themes and Import...
Malaria Transmission: Parasite and Vector Circadian Clock Coordination (April 2025) 04.04.2025 16:03
Parasite and Vector Circadian Clocks Mediate Efficient Malaria Transmission Source: Bento et al., "Parasite and vector circadian clocks mediate efficient malaria transmission," Nature Microbiology , Published online 31 March 2025, https://doi.org/10.1038/s41564-025-01949-1 Date: Received: 03 September 2024 | Accepted: 26 March 2025 | Published: 04 April 2025 Key Themes: This study uncovers a criti...
Radiation Induces Alternative Splicing in Aedes aegypti (March 2025) 24.03.2025 20:22
Briefing Document: Radiation-Induced Alternative Splicing in Aedes aegypti Mosquitoes Source: Bendzus-Mendoza, H., Rodriguez, A., Debnath, T., Bailey, C. D., Luker, H. A., & Hansen, I. A. (2025). Radiation exposure induces genome-wide alternative splicing events in Aedes aegypti mosquitoes. Scientific Reports , 15 , 5885. Date of Publication: Received - 19 June 2024 | Accepted - 14 March 2025...
Mosquito Prefoldin Targeting Blocks Plasmodium Transmission (March 2025) 07.03.2025 19:42
Briefing Document: Targeting the Mosquito Prefoldin–Chaperonin Complex to Block Plasmodium Transmission Citation: Dong, Y., Kang, S., Sandiford, S.L. et al. Targeting the mosquito prefoldin–chaperonin complex blocks Plasmodium transmission. Nat Microbiol (2025). https://doi.org/10.1038/s41564-025-01947-3 Date: Received - 22 November 2024 | Accepted - 27 January 2025 | Published - 06 March 2025 Ove...
Engineered Bacteria Combat Concurrent Malaria and Arbovirus Transmission (March 2025) 02.03.2025 22:19
Briefing Document: Engineered Symbionts for Concurrent Malaria and Arbovirus Transmission Control Citation: Hu, W., Gao, H., Cui, C. et al. Harnessing engineered symbionts to combat concurrent malaria and arboviruses transmission. Nat Commun 16, 2104 (2025). https://doi.org/10.1038/s41467-025-57343-2 Dates: Received - 27 July 2024 | Accepted - 19 February 2025 | Published - 01 March 2025 Prepared...
Mosquito Viral Tolerance Enhanced by Prolonged Heat Exposure (February 2025) 04.02.2025 15:19
Briefing Document: Heat Exposure and Mosquito-Virus Interaction Source: Perdomo, H. D., Khorramnejad, A., Cham, N. M., Kropf, A., Sogliani, D., & Bonizzoni, M. (2025). Prolonged exposure to heat enhances mosquito tolerance to viral infection. Communications Biology , 8 (1), 761. https://doi.org/10.1038/s42003-025-07617-8 Dates: Received - 27 September 2024 | Accepted - 28 January 2025 | Publis...
Bunyavirus NSm: Key to Transmission Between Vertebrates and Mosquitoes (January 2025) 31.01.2025 19:27
Briefing Document: NSm Protein's Critical Role in Bunyavirus Transmission Citation: Terhzaz, S., Kerrigan, D., Almire, F. et al. NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts. Nat Commun 16 , 1214 (2025). https://doi.org/10.1038/s41467-024-54809-7 Date: Received - 03 May 2024 | Accepted - 21 November 2024 | Published - 31 January 2025 Prepared for:...
Zika Virus Alters Human Skin to Attract Mosquito Vectors (January 2025) 30.01.2025 19:59
Detailed Briefing Document: Zika Virus Modulation of Human Fibroblasts Enhances Transmission Success Source: Mozūraitis, R., Cirksena, K., Raftari, M., et al. (2025). Zika virus modulates human fibroblasts to enhance transmission success in a controlled lab-setting. Communications Biology , 8 (1), 754. https://doi.org/10.1038/s42003-025-07543-9 Date of Briefing: Received - 02 July 2024 | Accepted...
Mosquito Hsf1-sHsp Cascade: A Pan-Antiviral Defense (January 2025) 25.01.2025 12:23
Briefing Document: Pan-Antiviral Activity of the Hsf1-sHsp Cascade in Mosquito Cells Source: Qu, J., Schinkel, M., Chiggiato, L., Machado, S. R., Overheul, G. J., Miesen, P., & van Rij, R. P. (2025). The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells. Nature Communications Biology , 8 (1), 74. https://doi.org/10.1038/s42003-024-07435-4 Date: Received - 05 July 2023 | Accepted -...
Toxic Seminal Proteins Reduce Female Insect Lifespan (January 2025) 07.01.2025 21:38
Briefing Document: "Recombinant venom proteins in insect seminal fluid reduce female lifespan" Source: Article "Recombinant venom proteins in insect seminal fluid reduce female lifespan" by Samuel J. Beach & Maciej Maselko, published in Nature Communications (DOI: 10.1038/s41467-024-54863-1). Date: Current date (based on when the briefing document is created). Prepared for: [Intended Audience...
Predicting Infectious Disease Outbreaks with AHP and Transfer Learning (December 2024) 31.12.2024 11:36
Briefing Document: Leveraging AHP and Transfer Learning for Infectious Disease Outbreak Prediction Dates: Received - 10 August 2024 | Accepted - 26 November 2024 | Published - 31 December 2024 Citation: Abdallah, R., Abdelgaber, S. & Sayed, H.A. Leveraging AHP and transfer learning in machine learning for improved prediction of infectious disease outbreaks. Sci Rep 14, 32163 (2024). https://do...
Ontario West Nile Virus: Mosquitoes, Humans, and Risk Factors (Nature, December 2024) 28.12.2024 16:22
Briefing Document: Spatial and Temporal Analysis of West Nile Virus Infection in Ontario, Canada (2003-2022) Citation: Talbot, B., Ludwig, A., O’Brien, S.F. et al. Spatial and temporal analysis of West Nile virus infection in mosquito and human populations based on arboviral detection testing data. Sci Rep 14 , 31343 (2024). https://doi.org/10.1038/s41598-024-82739-3 Dates: Received - 09 July 2024...
Explainable Deep Learning for Molecular Discovery (December 2024) 08.12.2024 19:18
Briefing Document: Explainable Deep Learning for Molecular Discovery Citation: Wong, F., Omori, S., Li, A. et al. An explainable deep learning platform for molecular discovery. Nat Protoc (2024). https://doi.org/10.1038/s41596-024-01084-x Dates: Received - 11 March 2024 | Accepted - 26 September 2024 | Published - 09 December 2024 Source: Excerpts from "An explainable deep learning protocol for de...
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