This Week in Virology

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Guest:  Nathan Letts The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins.   Become a  patron  of TWiV! Links for this episode Register  for ASV 2017 ASM-ASV  Conference on  Interplay of...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines.   Become a  patron  of TWiV! Links for this episode Register  for ASV 2017 Local Zika virus  transmission in Texas Texaszika.org Local dengue virus  transmission i...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus.   Become a  patron  of TWiV! Links for this episode Microcephaly  associated with Zika virus infection in Colombia (MMWR) Virophage  genome...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor. Become a  patron  of TWiV! Links for this episode New  mouse model  for MERS (Nat Micro) RNA-guided...

Host:  Vincent Racaniello Guest: Gary Nabel Vincent speaks with Gary Nabel, Chief Scientific Officer at Sanofi and former Director of the Vaccine Research Institute of NIAID, about his career and his work on HIV vaccines.   Become a  patron  of TWiV! Links for this episode World AIDS Day Video of this interview (YouTube) Send your virology questions and comments to twiv@microbe.tv

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The Fellowship of the Virus trace the early history of HIV in North America, based on genome sequences obtained from late 1970s archival sera, which also reveal that Gaetan Dugas was not Patient Zero.   Become a  patron  of TWiV! Links for this episode WHO: Zika virus is  no longer a PHEIC World AIDS...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!). Become a  patron  of TWiV! Links for this episode Predators  allow virus infection of endosymbiont (PNAS) Image credit...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Guests:  Jeremy Luban ,  Aaron Lin , and  Ted Diehl Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change i n the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells.   Become a  patron  of TWiV! Links for this episode Ebola...

Host:  Vincent Racaniello Guest:  Michael Diamond Michael Diamond visits the TWiV studio to talk about chikungunya virus and his laboratory's work on a mouse model of Zika virus, including the recent finding of testicular damage caused by viral replication.   Become a  patron  of TWiV! Links for this episode Chikungunya virus  chronic joint disease  caused by adaptive response (J Virol) Mouse mode...

Hosts:  Vincent Racaniello,   Alan Dove , and  Paul Duprex Guests:  Ralph Baric ,  Felix Drexler ,  Marion Koopmans , and  Stacey Schultz-Cherry From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Guest: Mark Fuccio The TWiVome reveal the first eukaryotic genes found in a bacteriophage of  Wolbachia , and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell.   Become a  patron  of TWiV! Links for this episode Zika virus in  vaginal secretions  (EID) Zika virus in  semen  (EID) Eukaryotic...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses.   Become a  patron  of TWiV! Links for this episode MicrobeTV Store Florida DOH  Daily Zika Update Zika virus in new Miami neighborhood ( CNN ,  NYTimes ) NDV...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Guests:  Sharon Isern  and  Scott Michael Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami.   Become a  patron  of TWiV! Links for this episode Live at Florida Gulf Coast University ( TWiV #111...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Guest:  Jeremy Luban Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.   Become a  patron  of TWiV! Links for this episode No recovery  in P...

Hosts:  Vincent Racaniello  and  Alan Dove Guest:  David Quammen Four years after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen.   Watch this episode at YouTube Become a  patron  of TWiV! Links for this episode David Quammen's  website Spillover  by...

Host:  Vincent Racaniello Guests:  Ralph Baric ,  Kristina De Paris ,  Tal Kafri ,  Helen Lazear ,  Mark Heise , and  David Margolis In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.   View vide...

Host:  Vincent Racaniello Guests:  Dirk Dittmer ,  Cary Moody ,  Nat Moorman ,  Nancy Raab-Traub ,  Lishan Su , and  Jennifer Webster-Cyriaque In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists. Vi...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiV team discussed eye infections caused by Zika virus, failure of  Culex  mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids.   Become a  patron  of TWiV! Links for this episode Florida DOH  daily Zika update Congress fails  again on Zika  (NY Times) C...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler The TWiXers discuss a study on vertical transmission of Zika virus by  Aedes  mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data.   Become a  patron  of TWiV! Links for this episode Roger Tsien , 64 (UC San Diego Health) CDC running out of  Zika money  (NYTimes) Zika virus in  Mi...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Rich Condit From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes.   Become a  patron  of TWiV! Links for this episode FluMist  problem  (FDA) DA Henderson  obituary  (NY Times) DA Henderson,  smallpox eradicator  (TWiV Special) Efficacy of...

Donald "D.A." Henderson, a physician, educator, and epidemiologist who led the World Health Organization's campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent  was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio.  Become a  patron  of TWiV! This episo...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Rich Condit The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine.   Become a  patron  of TWiV! Links for this episode Tribunal orders release  of PACE trial data (Valerie Eliot Smith) Our request  for PA...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Rich Condit Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV.   Become a  patron  of TWiV! Links for this episode Marian Horzinek , 80 (ProMedMail) Polio in Nigeria ( Atlantic ,  Stat ,  ProMedMail ) Zika virus  spreads in...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy.   Become a  patron  of TWiV! Links for this episode Beverly Griffin, 86 ( 1    2    3 ) Zika virus  in the US  ...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Guest:  Harold Varmus The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science.   Become a  patron  of TWiV! Links for this episode Varmus Laboratory Varmus and Kandel on  Charlie Rose  (transcript) Rescuing biomedical rese...