This Week in Virology

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies. Hosts:  Vincent Racaniello , Dickson Despommier , Rich Condit ,   Kathy Spindler , and Brianne Barker Guest: Michael Letko Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS...

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged

Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality. Hosts:  Vincent Racaniello , Alan Dove , Rich Condit ,  and Kathy Spindler Guest: Jake Scott Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  pat...

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, u...

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans. Host:  Vincent Racaniello Guest: Richard Knight Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! L...

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses...

David Quammen returns to TWiV to discuss how he wrote his new book 'Breathless', a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2. Hosts:  Vincent Racaniello , Rich Condit ,   Kathy Spindler , and Brianne Barker Guest: David Quammen Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for...

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative...

Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit ,  and Brianne Barker Guest: Angela Mingarelli Subscribe (free):  A...

In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of...

Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors. Hosts:  Vincent Racaniello , Rich Condit ,  and Kathy Spindler Guest: Kathryn Hanley Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Research assist...

In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and reboun...

Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples. This podcast is not an episode of TWiV, but I thought it would be of interest to listeners. Laurie Garrett and Vincent Racaniello Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episod...

Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them. Hosts:  Vincent Racaniello , Dickson Despommier , Rich Condit ,   Kathy Spindler , and  Brianne Barker Guest: Paul Offit Subscribe (free):  Apple Podcasts ,  Google Pod...

In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vacci...

Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab. Hosts:  Vincent Racaniello and Dickson Despommier Guest: Eddie Holmes Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links...

Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Guest: Tom Monath Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV!...

In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b...

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2. Hosts:  Vincent Racaniello Guest: Emma Thomson Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  o...

In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among v...

Vincent travels to Cornell University to speak with Cedric about his career and his research on mobile genetic elements such as transposons and endogenous viruses and how they have shaped the evolution of nearly all organisms. Hosts:  Vincent Racaniello Guest: Cedric Feschotte Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Fes...

In his weekly clinical update Dr. Griffin discusses variant influenza virus infections: recommendations for identification, treatment, and prevention for summer and fall 2022, low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals, using the right tools at the right time for SARS-COV-2 infection, onset and window of SARS-COV-2 infectiousness and tempo...

TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region. Hosts:  Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Resear...

In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable a...

TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Bria...