This Week in Virology

TWiV explains emergence of a neurovirulent double recombinant from the ‘improved’ nOPV2 in Uganda, and efficiency of viral entry determined whether cells are latently or lytically infected with cytomegalovirus. Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support scien...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss screwworm, how the shingles vaccination slows biological aging (for all of you who want to reset ‘the clock’ and live forever…..you know who you are Musk, Bezos) and getting one dose of the HPV vaccine, then Dr. Griffin then deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan d...

TWiV explains how the dengue virus protein NS1 alters Aedes aegypti midgut permeability and favors virus dissemination, and achieving a complete hepatitis B virus cure in chronic hepatitis B virus-infected humanized mice by using a capsid assembly modulator. Hosts:  Vincent Racaniello ,  Alan Dove , and Angela Mingarelli Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! L...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello are bewildered and dismayed by RFK Jr’s announced changes in the routine childhood immunization schedule, though not unpredicted, and highlight the science and evidence which eviscerate these changes, then deep dives into recent statistics on the measles epidemic- in particular in South Carolina, RSV, influenza and SARS-CoV-2 infect...

TWiV explain the tracing of 2500 years of human betaherpesvirus 6A and 6B diversity through ancient human DNA, the effect of shingles vaccination at different stages of the dementia disease course. Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science education ...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello are bewildered and dismayed by RFK Jr’s announced changes in the routine childhood immunization schedule, though not unpredicted, and highlight the science and evidence which eviscerate these changes, then deep dives into recent statistics on the measles epidemic- in particular in South Carolina, RSV, influenza and SARS-CoV-2 infect...

TWiV reviews compelling virology themes for 2024, as heard in our 98 episodes, including 22 guests. Hosts:  Vincent Racaniello  and  Kathy Spindler Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science education  at MicrobeTV ASV 2026 Dismantling of science and public health in the US including  TWiV 1199 ,  TWiV 1191 ,  TWiV 1197 ,  TWi...

Recording after the ball drops, Dr. Griffin and Vincent Racaniello wish everyone a Happy New Year, discuss an evidence-based approach to teaching and practice medicine and reminisce on the history of vaccine development and use before their discussion about the whooping cough outbreak of 2025 in the US and falling levels of tetanus vaccination, then Dr. Griffin then deep dives into recent statisti...

TWiV explains studies which reveal that Inhibition of CXCL10 and IFN-γ mitgates myocarditis associated with SARS-CoV-2 mRNA vaccination, and identification of a bacteriophage T7 protein that antagonizes the DNA restriction system of the host by mimicking B form DNA. Hosts:  Vincent Racaniello  and  Jolene Ramsey Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for...

Calling out “Happy Christmas to all and to all a good-night,  Dr. Griffin and Vincent Racaniello discuss high path influenza in dairy herds in Wisconsin and Marburg virus in Ethiopia before Dr. Griffin then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the slightly higher associati...

Vincent travels to Tegernsee, Germany for the Sixth Ringberg Symposium on Giant Viruses, where he talks with John Archibald, Susana Coelho, and Tom Delmont about their work on – you guessed it – giant viruses. Host:  Vincent Racaniello Guests:  John Archibald ,  Susana Coelho , and  Tom Delmont Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Trans...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello protest Vinjay Prasad, head of CBER FDA Nov memo stating administration of the COVID-19 vaccine resulted in 10 children’s deaths, but are cautiously delighted by the December memo from those in CBER who dispute this data-less claim, how in 31 states pertussis vaccination rates have declined before Dr. Griffin then deep dives into re...

TWiV reviews considerations and perspectives on phage therapy, and the Nobel Prize-winning discovery of hepatitis b virus. Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Jolene Ramsey Subscribe (free):  Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science education  at MicrobeTV Immune 100  live at the Incubator ASV 2026 WHO global expert...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the rise in norovirus infections, contamination of infant formula and botulism outbreak, confusion and response to the CDC’s ACIP decision to reverse the recommendation for a birth dose of the hepatis B virus vaccine and how states in the Northwest and Northeast are responding as well as some insurance companies, then deep d...

Infectious diseases physician Jake Scott returns to TWiV to discuss the dangerous anti-vaccine policies being established in the US and what RFK Jr. and his associates get wrong. Hosts:  Vincent Racaniello ,  Rich Condit , and Angela Mingarelli Guest:  Jake Scott Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science education  at Microbe...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the positive side effect of the shingles vaccine on dementia outcomes and how one dose of the HPV vaccine is non-inferior to two doses, but are dismayed about the FDA’s secrecy around the inflammatory statement that the COVID-19 vaccine is linked to the death of 10 children. Dr. Griffin then deep dives into recent statistics...

TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine. Hosts:  Vincent Racaniello ,  Kathy Spindler , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science education  at MicrobeTV Immune 100  live at the Incubator Spliced segments...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello wish everyone a Happy Thanksgiving and then decry appointment of the Louisiana State surgeon general as deputy chief of the CDC, the 3 children’s deaths during this fall’s pertussis outbreak, the Marburg virus outbreak in Ethiopia, results of the phase 1 safety trial for the novel poliovirus vaccines nOPV1 and nOPV3, and the first h...

TWiV explains the 1953 paper by Watson & Crick proposing a structure for DNA, and the role of Epstein-Barr virus in triggering the autoimmune disease systemic lupus erythematosus. Hosts:  Vincent Racaniello ,  Kathy Spindler , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science education  at MicrobeTV Immune 100  li...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello are dismayed by the changes on CDC vaccine website positively stating the link between autism and vaccination, the finding of wild type poliovirus 1 in Germany, Marburg virus in Ethiopia, decimation of the elephant breeding colony by H5N1 and the first human case of H5N5 influenza virus infection before Dr. Griffin deep dives into r...

Vincent visits Virginia Tech for the CeZAP Symposium and speaks with XJ Meng and Kylene Kehn-Hall about their research on hepatitis E virus and Rift Valley fever virus.   Host:  Vincent Racaniello Guests:  XJ Meng  and  Kylene Kehn-Hall Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science education  at MicrobeTV Immune 100  live at the...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello record from the ASTMH meeting in Toronto and discuss continuing avian flu outbreaks, the continued global measles outbreak, the effectiveness of high and low doses of the influenza vaccine before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dash...

TWiV reviews the passing of James D. Watson, the research that showed human papillomaviruses to be present in genital and laryngeal papillomas and in some cervical cancers, and influenza virus infection, shedding and symptoms in a human challenge study. Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of...

In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses the link between in utero SARS-CoV-2 infection and poor neurodevelopment outcomes, the use of an mRNA vaccine as an anti-cancer therapy, why one should receive the HPV vaccine, asymptomatic H5N1 isolations in humans, and H5N1 on turkey farms, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RS...

TWiV discusses the impact of vaccinating with Gardasil-9 adult women who are human papillomavirus positive or with confirmed squamous intraepithelial lesions, and human monoclonal antibodies that target the monkeypox virus A35 protein which protect against lethal disease. Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit ,  Kathy Spindler , and  Brianne Barker Subscribe (free): Apple Podcasts...