This Week in Virology

In his weekly clinical update, Daniel Griffin and Vincent Racaniello are dismayed over the military deaths due to the voluntary influenza vaccination policy, FDA’s first vaccine recommendations since 2023, the efficacy of influenza vaccines, new screwworm, Legionnaires and cyclosporiasis cases, the Ebola outbreak in the DRC and Uganda and before Dr. Griffin deep dives into the measles outbreak, re...

TWiV explains research that reveals an an alternative evolutionary path of antiviral signalling in a sea anemone, and how a bacterial symbiont and a plant virus enhance insect fitness by inducing physical defenses against fungal parasites. Hosts:  Vincent Racaniello ,  Alan Dove , and  Rich Condit Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Su...

In his weekly clinical update, Daniel Griffin and Vincent Racaniello lament about the new ACIP charter, how administration of the HPV vaccine has eliminated cervical cancer deaths in young women, the global economic burden of infectious disease, restoring trust in vaccinology, new screwworm cases, the Ebola outbreak in the Congo and Uganda and need for preparedness, before Dr. Griffin deep dives i...

Vincent speaks with Karen Torghele about her recently published biography of polio vaccine pioneer Albert Sabin, the first ever written. Host:  Vincent Racaniello Guest:  Karen Torghele Subscribe (free): Apple Podcasts ,  RSS ,  email Links for this episode Karen Torghele’s website Purchase  Albert Sabin  by Karen Torghele ( Bookshop  or  Amazon ) My letters from Albert Sabin ( virology blog ) Bec...

TWiV explains research showing how temperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling, and that IgA antibody is necessary and sufficient to prevent norovirus infection in mice. Hosts:  Vincent Racaniello ,  Rich Condit ,  Brianne Barker , and  Jolene Ramsey Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support s...

In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the global economic burden of infectious disease, restoring trust in vaccinology, the Legionnaires outbreak in Harlem, new screwworm cases, the Ebola outbreak in the Congo and Uganda and an import case into France, end of the hantavirus outbreak before Dr. Griffin deep dives into the measles outbreak, recent statistics RS...

In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the global economic burden of infectious disease, restoring trust in vaccinology, the Legionnaires outbreak in Harlem, new screwworm cases, the Ebola outbreak in the Congo and Uganda and an import case into France, end of the hantavirus outbreak before Dr. Griffin deep dives into the measles outbreak, recent statistics RS...

TWiV explains research showing how HIV-1 signalling remodels nuclear pores to licence infection, and development of STING agonist nanoparticles to enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection. Hosts:  V Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this...

Vincent travels to ASM Microbe in Washington DC to speak with John Dye of the United States Army Medical Research Institute of Infectious Diseases about the recent outbreaks of Bundibugyo ebolavirus in Africa and Andes virus on a cruise ship. Host:  Vincent Racaniello Guest:  John Dye Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Intro music is by  Ronald Jenkees Send...

In his weekly clinical update, Daniel Griffin and Vincent Racaniello express concern  about vaccine policy and ACIP, scaling back of the CDC’s role in global public health, shingles vaccine and dementia, new screwworm cases, the Ebola outbreak in the Congo and Uganda and where the hantavirus outbreak began, before Dr. Griffin deep dives into the measles outbreak, recent statistics on RSV, influenz...

TWiV explains research showing that dairy cows are infected with low doses of influenza A(H5N1) and do not transmit efficiently to other animals, and covalent inhibitors of human papillomavirus type 16 E6 protein that restore p53 function and suppress growth of HPV-driven tumors in vivo. Hosts:  Vincent Racaniello ,  Rich Condit ,  Brianne Barker , and Angela Mingarelli Subscribe (free): Apple Pod...

In his weekly clinical update, Daniel Griffin and Vincent Racaniello opine on the recent executive order on the routine childhood vaccination schedule, the Ebola outbreak in the Congo and Uganda including the fast track trials for 2 vaccine candidates and antivirals, recent Hantavirus infections, use of quarantined “Hantavirus” patients for the governmental propaganda machine, use of ribavirin and...

TWiV explains research showing limited transmission of cervid prions to nonhuman primates, and the finding that cone-shaped HIV-1 capsids are transported through intact nuclear pores. Hosts:  Vincent Racaniello ,  Alan Dove , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science education  at MicrobeTV Positions in Ro...

In his weekly clinical update, Daniel Griffin and Vincent Racaniello opine on the recent executive order on the routine childhood vaccination schedule, the Ebola outbreak in the Congo and Uganda including the fast track trials for 2 vaccine candidates and antivirals, recent Hantavirus infections, use of quarantined “Hantavirus” patients for the governmental propaganda machine, use of ribavirin and...

TWiV explains research on human influenza virus transmission that reveals heterogeneous expulsion of infectious virus into air, and how gut bacteriophages dictate inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn’s disease. Hosts: Vincent Racaniello ,  Rich Condit ,  Brianne Barker , and  Jolene Ra m sey Subscribe (free): Apple Podcasts ,  RSS ,  emai...

In his weekly clinical update, Daniel Griffin and Vincent Racaniello comment on incidences of locally transmitted malaria in the US, mpox diagnostics, the latest developments surrounding hantavirus infections, and the Ebola outbreak in the Congo and Uganda including vaccine candidates before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infection...

Vincent travels to Oregon State University in Corvallis to meet up with Hannah Rowe to talk about her career and her work demonstrating how the interaction of influenza A virus and Streptococcus pneumonia influences transmission. Hosts:  Vincent Racaniello Guest:  Hannah Rowe Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science educatio...

In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss withdrawal of the ACIP charter published in April 2026, the first council meeting on antibiotic resistant bacteria, the latest developments surrounding hantavirus infections, and the Ebola outbreak in the Congo and Uganda before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-Co...

TWiV explains mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines, and how toll-like receptor 7 alters the maternal immune landscape during influenza A infection to increase maternal and fetal morbidity, Hosts:  Vincent Racaniello ,  Rich Condit , and  Kathy Spindler Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support science education  at...

In his weekly clinical update, Daniel Griffin and Vincent Racaniello reviewed the latest developments surrounding the hantavirus outbreak, including new interim guidance from the Centers for Disease Control and Prevention for the management of infectious cases, whether the CDC may be downplaying the significance of the outbreak because of public backlash following the COVID-19 pandemic, before Dr....

TWiV explains how cross-reactive anti-prophage antibodies and bacterial heteroresistance is implicated in phage therapeutic failure, and how phages communicate across species to shape microbial ecosystems. Hosts:  Vincent Racaniello ,  Rich Condit ,  Brianne Barker , and  Jolene Ramsey Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Support scienc...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the outbreak of Hantavirus on a cruise ship and its potential for person-person transmission, how cessation of funding for global health by the Trump administration has compromised American health and well being, as well as the description of paralytic poliomyelitis outbreaks in Central Africa associated with the administrat...

TWiV explains the emergence of vaccine-derived poliovirus strains from the novel oral polio vaccine in the Central African Republic, and the infection of spiral ganglion neurons in the inner ear by SARS-CoV-2, which may explain hearing loss in humans. Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for...

In his weekly clinical update, Dr. Griffin and Vincent Racaniello note the uncertain future of the National Science Foundation amid shifting U.S. funding priorities and governance; the rise of China as a global research powerhouse; ongoing advances and controversies in vaccines shaped by the World Health Organization and the Centers for Disease Control and Prevention; vaccine policy battles in Flo...

TWiV explains a study showing that viral DNA load in blood and saliva varied markedly with age, time of day season, sex, and depended on dozens of genetic loci, and identification of an emerging human eye disease associated with aquatic virus zoonotic infection. Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  p...