This Week in Pediatric Oncology

August 19, 2011 Host Dr. Tim Cripe and co-hosts Dr. Lionel Chow and Dr. Jim Geller discuss updates to previous TWiPO episodes reporting on recent press coverage and publications of BiTE antibodies and modified T-cell approaches, and then discuss recent studies on birth defects, birth order, and cell phone use and possible link to risk of childhood cancers. N Engl J Med. 2011 Aug 10.  Chimeric Anti...

August 05, 2011 Host Dr. Tim Cripe and co-host Maureen O’Brien discuss recent papers on immunotherapy and DNA sequencing studies revealing new potential targets in acute lymphoblastic leukemia (ALL). 1:45 min. Results on use of BiTE antibody (Bi-specific T-cell engaging) blinatumomab in adults with lymphoma and leukemia: Exp Cell Res. 2011 May 15;317(9):1255-60. Epub 2011 Mar 16.  Immunomodulatory...

July 12, 2011 In this eleventh episode of "This Week in Pediatric Oncology" hosts Dr. Tim Cripe and Dr. Lars Wagner discuss with guest Dr. Brian Weiss (Cincinnati Children's Hospital) the implications of the recent results comparing two chemotherapy combinations for transplant regimens in children with high-risk neuroblastoma in Europe. The BuMel (busulfan, melphalan) regimen resulted in better su...

July 07, 2011 "This Week in Pediatric Oncology" podcast host Dr. Tim Cripe interviewed Dr. Robert Seeger from CHLA (Children's Hospital of Los Angeles) about his contributions to improvements in treating neuroblastoma as well as his vision for future advances. Dr. Seeger's career has been remarkable in that he began with an interest in immunotherapy and neuroblastoma as an intriguing model for thi...

June 16, 2011 Host Dr. Tim Cripe of "This Week in Pediatric Oncology" podcast interviews Dr. Peter Adamson, new Chair of the Children's Oncology Group (COG). Co-hosts for this episode are Dr.  Jim Geller, Dr. Raj Nagarajan, and Dr. Lionel Chow. This conversation includes Dr.  Adamson's background and interest in pediatric oncology, and openly addresses the much-needed advances in drug development...

June 09, 2011 An oncolytic virus for a common childhood brain tumor In this eighth episode of "This Week in Pediatric Oncology" podcast hosts Dr. Tim Cripe, Dr. Lars Wagner and Dr. Lionel Chow discuss a recent publication by researchers at Baylor/Texas Children's in Houston that shows remarkable results of Seneca Valley virus SVV-001 on orthotopic mouse models of medulloblastoma. The TWiPO hosts r...

June 02, 2011 In this seventh episode of "This Week in Pediatric Oncology" TWiPO podcast, host Dr. Tim Cripe interviews Dr. E. Anders Kolb and Dr. Andrew Napper  from Nemours in Wilmington, Delaware. This informative discussion covers the strategies, scope, and challenges of target discovery, drug development, and preclinical testing for pediatric cancers, a complex process that has been accelerat...

May 26, 2011 In this sixth episode of TWiPO, Dr. Tim Cripe interviews Dr. Archie Bleyer about his career and research interest in improving survival rates in adolescents and young adults (AYA) affected by cancer. Dr. Bleyer is the Medical Director of , Clinical Research at St. Charles Cancer Care in Bend, Oregon and a Clinical Research Professor at Oregon Health & Sciences University in Portland....

May 19, 2011 Discussion of the role of hedgehog signaling and repositioning of drugs for pediatric cancers such as anti-fungal drug itraconazole In this fifth episode, hosts Dr. Tim Cripe and Dr. Maureen O'Brien discuss the role of targeting of hedgehog signaling in diffuse intrinsic pontine glioma (DIPG) and the use of drugs designed for other uses -- designed for other uses -- such as itraconazo...

May 08, 2011 In this fourth episode of TWiPO host Dr. Tim Cripe and co-host Dr. Jim Geller discuss updates after two recent meetings and then discuss an exciting paper just published on "Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1"  J Clin Oncol. 2011 Mar 1;29(7):917-24. Epub 2011 Jan 31.  by Paul R...

April 25, 2011 In this third episode, host Tim Cripe, MD, PhD, asks his co-hosts to discuss two recent papers that provide new information about genetic predisposition to increased toxicity to vincristine in some children, and the results of a phase II study using a combination therapy (irinotecan and temozolomide) in relapsed or refractory neuroblastoma. 1:24 Maureen O'Brien, MD discusses "Increa...

April 13, 2011 In this second episode of TWiPO, host Dr. Tim Cripe interviews  Dr. Gregory Reaman  about his career in pediatric oncology, leadership of the COG, challenges, and expectations for the future.

April 11, 2011 Solving Kids' Cancer is sponsoring a free podcast series for researchers, clinicians, advocates, and others focusing on pediatric cancer research, hosted by physician-scientist  Dr. Timothy Cripe  and colleagues at Cincinnati Children's. Podcasts will be published 2 to 4 times per month with discussions on new publications, clinical trials, interviews with thought leaders, and more....