This Week In Medicine

This research explores the intricate genetic link between childhood maltreatment and psychiatric conditions, such as ADHD and depression, by analyzing the DNA of over 100,000 individuals. The study reveals that a person's biological predisposition—specifically genetic markers related to ADHD and educational attainment—can significantly influence their likelihood of experiencing early-life trau...

This research study evaluates the health impact of medical imaging by predicting that the roughly 93 million CT scans performed in 2023 will lead to approximately 103,000 future cancer cases. While younger patients face a higher individual risk from ionizing radiation, the sheer volume of procedures in adults—particularly abdominal and chest scans—is responsible for the vast majority of projected...

This scientific study investigates the potential link between pesticide exposure from golf courses and the likelihood of developing Parkinson disease. Researchers discovered that individuals living within a short distance of these facilities faced significantly higher odds of a diagnosis, with the risk generally decreasing as the distance from the greens increased. A major focus of the analysis wa...

This nationwide Swedish study investigates how the choice of an initial blood pressure medication influences whether a patient will remain on their treatment over several years. By analyzing data from hundreds of thousands of individuals, researchers discovered that those starting with angiotensin receptor blockers (ARBs) demonstrated the highest level of long-term consistency and the fewest chang...

This collection outlines a series of groundbreaking clinical trials slated to conclude or produce results by 2026, representing a new frontier in the treatment of chronic and infectious diseases. The text is structured as a survey of diverse medical fields, highlighting innovations such as long-acting HIV antibodies, mRNA-based immunotherapy for autoimmune disorders, and precision gene editing to...

This study, known as ALIGN-AR, investigated the use of the Trilogy valve, a device specifically engineered for native aortic regurgitation (AR), a condition where older devices optimized for calcific aortic stenosis were not suitable. The research followed high surgical risk patients with symptomatic moderate-to-severe or severe AR undergoing a transcatheter aortic valve intervention (TAVI) to ass...

This study, rooted in a 25-year prospective cohort study of over 27,000 participants in Sweden, sought to clarify the relationship between various dairy product consumption levels and the long-term risk of dementia. Researchers meticulously tracked dietary habits and subsequent diagnoses of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) to discover that higher intake...

This randomized clinical trial, called VALAD, investigated whether the antiviral drug valacyclovir could be an effective treatment for individuals diagnosed with early symptomatic Alzheimer disease who also tested positive for the herpes simplex virus (HSV). The study was motivated by evidence suggesting a potential link between HSV and the etiology of Alzheimer disease. Researchers compared a val...

This research evaluates whether using smoking duration instead of the current pack-year criteria for U.S. national lung cancer screening could improve equity across different racial and ethnic groups. The study utilized a multi-ethnic cohort to compare the eligibility rates and prognostic performance of the 2021 U.S. Preventive Services Task Force (USPSTF-2021) guidelines against a proposed 30-yea...

NEJM articles: Volume 393 No. 23 December 11, 2025 This research details a phase 3 randomized clinical trial comparing a novel combination therapy to traditional chemotherapy for patients with HER2-expressing advanced urothelial cancer. The study investigated the efficacy of disitamab vedotin, a HER2-targeting antibody–drug conjugate, combined with the PD-1 immunotherapy toripalimab against standa...

NEJM articles: Volume 393 No. 23 December 11, 2025 This clinical trial investigated whether adding the drug ticagrelor to standard aspirin therapy would improve outcomes for patients who had undergone coronary-artery bypass grafting (CABG) for an acute coronary syndrome. Researchers randomly assigned over 2,200 patients across Nordic centers to receive either the combination therapy or aspirin alo...

NEJM articles: Volume 393 No. 23 December 11, 2025 The provided text summarizes two distinct, large-scale, randomized controlled trials investigating the effectiveness of the high-dose inactivated influenza vaccine compared to the standard dose in older adults (aged 65 and older). Both studies sought to determine if the high-dose vaccine offered superior protection against severe clinical outcomes...

Hi, This Week in Medicine, we will be discussing  New England Journal of Medicine   Hypertonic Saline or Carbocisteine in Bronchiectasis   Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation   Common Diseases in Clinical Cohorts — Not Always What They Seem   Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis   Journal of  American Me...

Hi, This Week in Medicine, we will be discussing  New England Journal of Medicine   Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer   A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus   Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency   Mass Administration of Azithromycin to Infants in Mali to Reduce Mortality   Journal of ...

Here are the  articles   from Kidney International reports A New Prognostic Score Based on Cell-Mediated Immunity for Cytomegalovirus Infection After Transplantation Introduction The interferon gamma (IFN-γ) enzyme-linked immunosorbent spot is a highly sensitive immune assay that enables the assessment of cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) and can identify at-risk transpla...

Hi, This Week in Medicine, we will be discussing First we will be discussing articles in New England Journal of Medicine   Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer   Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity   Proportional-Assist Ventilation for Minimizing the D...

Hi, This Week in Medicine, we will be discussing  New England Journal of Medicine   Aficamten or Metoprolol Monotherapy for Obstructive Hypertrophic Cardiomyopathy   Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy   Multidomain Rehabilitation for Older Patients with Myocardial Infarction   Journal of  American Medical Association Biparametric vs Multiparametric MRI for Prostat...

Hi, This Week in Medicine, we will be discussing First we will be discussing articles in New England Journal of Medicine   Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer   Elinzanetant for Vasomotor Symptoms from Endocrine Therapy for Breast Cancer   Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis   Adjuvant Cemiplimab or Placebo in...

Hi, This Week in Medicine, we will be discussing New England Journal of Medicine   Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity   Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes   A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline   Journal of  American Medical Association  Dalbavancin for Treatme...

Hi, This Week in Medicine, we will be discussing First we will be discussing articles in New England Journal of Medicine   Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes   Ciprofloxacin versus Aminoglycoside–Ciprofloxacin for Bubonic Plague   Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer   First-Line Camizestrant for Emerging ESR1-Mutate...

Hi, This Week in Medicine, we will be discussing  New England Journal of Medicine   Measurable Residual Disease–Guided Therapy in Newly Diagnosed Myeloma   A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery  Journal of  American Medical Association Impact of the MISSION Act on Quality and Outcomes of Major Cardiovascular Procedures in Veterans  Annals of Internal Medicine Soc...

Hi, This Week in Medicine, we will be discussing First we will be discussing articles in New England Journal of Medicine   Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes without Previous Insulin Therapy   Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer   Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy   Ivermectin to Control Malaria — A Cluster...

Hi, This Week in Medicine, we will be discussing New England Journal of Medicine   Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer   First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate   Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin   Journal of  American Medical Association Hepatitis C Screening in Emergency Departme...

Hi, This Week in Medicine, we will be discussing  New England Journal of Medicine  As-Needed Albuterol–Budesonide in Mild Asthma   Global Effect of Cardiovascular Risk Factors on Lifetime Estimates   Intravenous Tenecteplase before Thrombectomy in Stroke   Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer Journal of  American Medical Association Obesity Variation Among Asia...

Hi, This Week in Medicine, we will be discussing  New England Journal of Medicine   Structured Exercise after Adjuvant Chemotherapy for Colon Cancer   Tirzepatide as Compared with Semaglutide for the Treatment of Obesity   Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer   Journal of  American Medical Association Lorundrostat in Participants With Uncontrolled Hyperte...