TheSugarScience Podcast- curating the scientific conversation in type 1 diabetes

In this episode, Dr. Emily Sims joins us to discuss her research focused on diabetes risk factors and treatments to predict or slow diabetes progression. Tune in to learn more about her recent publication on teplizumab, titled "Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals".  Click here to read the full paper. 

In this episode, Alex Cogdill joins us to discuss Immunai. Immunai is an innovative biotech company that works with partners to discover and develop therapies through the integration of machine learning and single-cell multimodal omics at scale. Dr. Cogdill has 13 years of experience in drug discovery and research management; having published >50 scientific articles in the immuno-oncology space wi...

In this episode, Wendy Wolf joins us to talk about T1D Exchange and the work they are doing to improve T1D research. T1D Exchange strives to improve outcomes for the T1D population by driving real-world evidence and collaborative change. Their Registry is a long-term research study where individuals volunteer their data to contribute to research evidence.  Learn more about T1D Exchange here , and...

In this episode, Peter Senior and Kate Farnsworth join us to discuss the exciting work taking place at Diabetes Action Canada.  Diabetes Action Canada recently launched Connect1d. This platform allows those living with T1D to contribute to research in areas that matter most to them, while also allowing researchers to engage with a diverse range of people living with T1D from across Canada.   Inter...

In this episode, Dr. José García-Tirado joins us to discuss his work with the individualization of behavior patterns (including eating and exercise patterns) from CGM, insulin pump, and activity tracker data. Click on the links below for some of his recent papers.  Mapping data to virtual patients in type 1 diabetes Anticipation of Historical Exercise Patterns by a Novel Artificial Pancreas System...

In this episode, Amelia Linnemann joins us to speak about the mechanisms of adaptive stress response in the pancreatic islet. Dr. Linnemann provides us with some insight about a recent publication, Pancreatic beta cell autophagy is impaired in type 1 diabetes. Learn more about her work here

In this episode, Qiufu Ma joins us to discuss the ongoing research taking place in his lab. Dr. Ma's lab focuses on two lines of research: mapping pain pathways and exploring how acupuncture works. Tune in to hear Dr. Ma discuss one of his recent publications, Somato-Autonomic Reflexes of Acupuncture . Learn more about Ma Lab here

In this episode, Gaël McGill joins us to discuss ways in which cell and molecular visualization can inform the research and discovery process. Dr. McGill is the founder of Digizyme. Digizyme's mission is to innovate at the intersection of science, technology, art and learning to create accurate and effective visual context for understanding science.   Follow the link below for an animation video t...

In this episode, David Wraith joins us to discuss his profound knowledge on autoimmunity and immunotherapy. His research team has revealed mechanisms whereby autoreactive T-cells escape deletion in the thymus and thus appear in the repertoire of all individuals. He also demonstrated that autoreactive T-cells can be silenced by suitable administration of fragments of their protein targets.

In this episode, Jessica Gibson joins us to discuss the latest work at Ariel Precision Medicine. Ariel is a health technology company seamlessly integrating complex genetics into clinical decision-making, empowering doctors and patients to prevent, mitigate or even reverse disease progression. Ariel's initial focus is pancreatic diseases including pancreatitis, diabetes and pancreatic cancer. Lear...

In this episode, Josh Nicholson joins us to discuss how to use Scite. Scite is a deep learning platform that evaluates the reliability of scientific claims by citation analysis. Scite is a very valuable tool for all researchers.  Smart citations for better research. Checkout scite here!

In this episode, Bart Roep joins us to discuss the latest progress at City of Hope in the quest to cure type 1 diabetes. Early 2020 marked a milestone for science funded by The Wanek Family Project. Results had come in from a first-in-humans clinical trial testing a “reverse vaccine” for type 1 diabetes developed by Roep and his colleagues. The research showed the treatment to be safe and even ind...

In this episode, Scott Soleimanpour joins us to discuss his fascinating research taking place at the University of Michigan. Dr. Soleimanpour provides details about a recent publication, Mitophagy protects β cells from inflammatory damage in diabetes.  Dr. Soleimanpour's lab focuses on the molecular and genetic regulation of the mitochondrial life cycle, with a focus on mitophagy, a pathway to dis...

In this episode, Darleen Sandoval joins us to discuss her research and recent publication, Updating the Role of α-Cell Preproglucagon Products on GLP-1 Receptor–Mediated Insulin Secretion. Dr. Sandoval's current work utilizes basic research strategies to focus on two general themes of research. The first goal is to gain understanding on the role of a gastrointestinal peptide, GLP-1, in the gut-bra...

In this episode, Ed Boyden joins us to discuss his research at MIT and how an imaging technology developed by Boyden and his colleagues is applicable to type 1 diabetes researchers. Dr. Boyden leads the Synthetic Neurobiology Group, which develops tools for analyzing and repairing complex biological systems such as the brain, and applies them systematically to reveal ground truth principles of bio...

In this episode, Dame Frances Ashcroft joins us to discuss her research and recent publication titled, Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells .  Dr. Frances Ashcroft's research focuses on ATP-sensitive potassium (KATP) channels and their role in insulin secretion, in both health and disease. To learn more about her research visit her website below. Ashc...

In this episode, Teresa Rodriguez-Calvo joins us to discuss her type 1 diabetes research at the International Helmholtz Research School for Diabetes. Dr Rodriguez-Calvo is interested in the crosstalk between the immune system and the cells that produce insulin, called beta cells. We are working on identifying the cells that recognize different beta cell antigens and their exact localization in the...

In this episode, Susan Wong joins us to discuss her years of research experience working on the aetiology and pathogenesis of type 1 diabetes. Dr. Wong also discusses one of her recent publications, Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype . Follow the link below to read more...

In this episode, Francisco Leon joins us to discuss how he became scientifically interested in type 1 diabetes and what led him to where he is today. Dr. Leon is the CSO and Co-Founder of Provention Bio. Provention Bio's mission is to change the world by unleashing the full potential of lives otherwise burdened of cut short by autoimmune disease.  Provention Bio has an exciting pipeline of investi...

In this episode, Yong Zhao joins us to discuss Tianhe Stem Cell Biotechnologies Inc. and the progress of clinical trials using the stem cell educator. Tianhe’s notable Stem Cell Educator Therapy was invented by Dr. Yong Zhao to effectively reverse the root causes of autoimmune diseases. Over the last 10 years, international multi-center clinical studies in the United States, China, and Spain have...

In this episode, Julie Sneddon joins us to discuss exciting type 1 diabetes research taking place in her lab. Dr. Sneddon’s laboratory studies the underlying biology of the cellular microenvironment, including the cellular diversity and lineage relationships of the non-epithelial compartment of the pancreas in the context of organogenesis, adult organ function, and disease. Recently, Dr. Sneddon w...

In this episode, Emrah Altindis joins us to discuss his excellent publication, Parabacteroides distasonis insulin B:9-23 epitope mimic stimulates insulin specific T-cells and enhances type 1 diabetes in NOD mice . The main goal of Dr. Altindis' lab is to better understand the role of microbial mimicry mechanisms in human diseases and characterize these microbial proteins. In addition to the potent...

In this episode, Roland Eils and Luca Tosti join us to discuss their research in the type 1 diabetes space. Scientists from the BIH are coordinating an international project on the single-cell analysis of the human pancreas. The project is part of a global project- known as the Human Cell Atlas. Dr. Eils and Dr. Tosti provide us with information about the Human Cell Atlas. 

In this episode, Per-Ola Carlsson joins us to discuss his latest research. Dr. Carlsson's work focuses on developing means to intervene with the development of type 1 diabetes mellitus and find treatment strategies to restore glucose homeostasis in patients with type 1 using cell therapy.  Want to read more about his work? Checkout a recent publication, Better HbA1c during the first years after di...

In this episode, Reena Singh joins us to discuss her research and one of her recent publications titled, Enhanced Structure and Function of Stem Cell-Derived Beta-Like Cells Cultured on Extracellular Matrix. Dr. Singh is a developmental and stem cell biologist and her current area of research is to develop cell replacement therapy for people living with type 1 diabetes. Dr. Singh is working toward...