TheSugarScience Podcast- curating the scientific conversation in type 1 diabetes

Dr. Victoria Salem joins us to discuss in-vivo evidence for islet "hub cells".    Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!   https://thesugarscience.org/ask-the-expert/

Milena Pavlovic and Lenneke Schieffer join us to discuss Immune ML, an "open-source ecosystem for machine learning analysis of adaptive immune receptor repertoires.    ImmuneML website: https://immuneml.uio.no/   Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up...

Dr. Braden Tierney joins us to discuss gene-level metagenomic architectures across diseases that yield high-resolution microbiome diagnostic indicators.    This episode is in our Ask the Expert style:  Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat...

In this Ask the Expert podcast we talk with Carmen Valcarce PhD and Klara Klein MD PhD from VTV Therapteutics. We discuss TTP399 development as an adjunct therapy to insulin in patients with Type 1 Diabetes. This episode is in our Ask the Expert style:  Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field...

Topic: What are the most promising approaches for beta cell replacement moving forward? Anchors: Doug Melton PhD (HSCI), Ali Naji MD PhD (PENN), Mike Rickles MD (PENN), Felicia Pagliuca PhD (Vertex) Matthias Hebrok PhD, (UCSF) Panel: Jon Odorico MD (U Wisc), Pete Butler MD (UCLA) Cherie Stabler, PhD (UF), Mark Atkinson, PhD (UF), Ekaterine Bershivili MD PhD (UGeneva) WHAT: State of the Science is...

Dr. Jessica Kenison joins us to discuss re-balancing the immune system and introducing antigen-specific immune tolerance to treat T1D. Dr. Jessica Kennison is a Postdoctoral Research Fellow at Brigham and Women's Hospital and Scientist at AnTolRx, Inc. This episode is in our Ask the Expert style:  Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet an...

In this episode, Dr. Teresa Mastracci joins us to discuss the exocrine pancreas in T1D; is it a player, or merely a spectator?  Dr. Mastracci is an Assistant Professor in Biology at Indiana University. In 2017 she was named one of the top Ten Under 40 up & coming stars in Biopharma Research and Business by Genetic Engineering News and was recognized as one of the Indianapolis Business Journal’s Fo...

In this episode, Dr. Elliot Botvinick joins us to talk about his work with multi-analyte sensing and insulin infusion at UCI. Tune in to hear about iGLOBE.  This episode is in our Ask the Expert style:  Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a sea...

In this episode, Dr. Andrew Wang, Dr. Kin Man Au, and Dr. Roland Tisch from the University of North Carolina join us to discuss their recent work, including the recent publication, "Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes".    Full paper link: https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202101253   This episode is in our Ask the Expert style...

In this episode, Dr. Jonathan Weissman joins us in our Ask the Expert format to discuss genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.  This episode is in our Ask the Expert style:  Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to si...

In this episode, Rob Screaton joins us to discuss one major question: Can we get adult human beta cells to regenerate? His lab uses high-throughput functional genomic imaging screens to identify novel players involved in cell signaling pathways that control human pancreatic beta cell proliferation. In addition, we are interested in the function and quality control of mitochondria, critical subcell...

In this episode re-release, Avnesh Thakor joins us to discuss bioscaffolds that are used to support pancreatic islet transplantation. Dr. Thakor's research interests are focused primarily on the pancreas, with respect to regenerative medicine and oncology. In Thakor's lab, they are creating biocompatible 3D structures which contain spaces to accommodate islets. These bioscaffolds will aim to facil...

In this episode, Professor Matthias Barth joins us to discuss his work studying higher education at Leuphana University in Germany. Dr. Barth is one of the steering-group members of the Postdoc Academy for Transformational Leadership, a training programme for researchers in the sustainability field. 

In this episode, David Wagner joins us to present and answer questions on his work at the University of Colorado and with Op-T-Mune. This episode is in our Ask the Expert style:  Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe! https://t...

In this episode, Eiji Yoshihara joins us to discuss the research taking place at Yoshihara Lab at the Lundquist Institute. The overarching goal of the Yoshihara Lab is to understand the origins of life and physiology through utilizing state-of-the-art biomedical technologies. Japanese Translation @ minute 25 Learn more about the Yoshihara Lab Here

In this episode, Dr. Toby Coates joins us to give us some insights into his work with the Biodegradable Temporizing Matrix (BTM). 

In this episode, Matthieu Raoux joins us to talk about his fascinating research at the University of Bordeaux, France. Dr. Raoux provides insights to his recent publication: Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets . " Our data provide a new uni- and multicellular model of islet β-cell activation: during the 1st phase, small but highly active β-cell clu...

In this episode, Professor Noel G. Morgan joins us to discuss his work in cellular pharmacology and studying the pathophysiology of pancreatic beta-cells in diabetes. He also talks about his work with B cells and a recent publication, "Footprints of Immune Cells in the Pancreas in Type 1 Diabetes; to “B” or Not to “B”: Is That Still the Question?".  Link to his paper: https://www.frontiersin.org/a...

In this episode, we speak with Alok Joglekar about his fantastic research at the University of Pittsburg. Dr. Joglekar provides us with some insights to his publication: T cell antigen discovery. T cells play a critical role in the elimination of pathogens and the surveillance of pathological cells.   Read the full text here

In this episode, Dr. Matthias von Herrath joins us to discuss his work at the La Jolla Institute for Immunology and at pharmaceutical company Novo Nordisk. He discusses one of his recently published papers, "Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial"...

In this episode, we speak to Dr. Hans Sollinger, MD, PhD, Founder & Interim CSO of Endsulin. Dr. Sollinger has been a leader in diabetes care for decades and has revolutionized the field twice.    Endsulin is overcoming the limitations of today's taxing diabetes treatments with a patented gene construct and simple process that re-engineers part of the liver, allowing it to produce and regulate ins...

In this episode, Burcak Yesildag joins us to discuss her work in the Islet Solutions Group at InSphero, generating advanced and high-throughput compatible assays and disease models for diabetes drug discovery. She also gives us some insight into a recent publication, "Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes".  Full paper: Human Islet Microtissues as an In V...

In this episode, Arun Sridhar and Philippe Blancou join us to discuss their innovative work in the type 1 diabetes space. These researchers provide us details about one of their recent publications: Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes.  Arun Sridhar is the host of Skraps , a top 10% rated scientific podcast. Tune in to listen to stories of scientific brill...

In this episode, Dr. Ying Liu along with PhD students Paola Leon Plata and Maryam Zaroudi join us to talk about their recent publication, "Heterogeneous Toroidal Spiral Particles for Islet Encapsulation". Liu Laboratory at the University of Illinois Chicago Department of Chemical Engineering focuses on nano- and micro- materials to address current challenges in drug delivery and tissue engineering...

In this episode, Laia Gómez Muñoz joins us to discuss her recent publication, NK Cell Subsets Changes in Partial Remission and Early Stages of Pediatric Type 1 Diabetes . Laia is a PhD student at the Immunology of Diabetes Group under the supervision of Dra. Marta Vives. Her research focuses on the identification of new biomarkers of partial remission in pediatric patients with autoimmune diabetes...