The ReProgram

🧠 Episode Overview What if aging is shaped not only by what you eat, how much you exercise, or which genes you inherit — but also by when your body does things each day? In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Mimi Shirasu-Hiza at the Gordon Research Conference Systems Aging Meeting in Maine. Dr. Shirasu-Hiza is a Professor of Genetics and Development at Columbia Un...

🧠 Episode Overview What if “biological age” as a single number is the wrong way to think about aging? In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Rich Miller at the Gordon Research Conference Systems Aging Meeting in Maine. Dr. Miller is a Professor of Pathology at the University of Michigan and one of the leaders of the Interventions Testing Program, the gold standard...

🧠 Episode Overview Are GLP-1 agonists longevity drugs? Not weight loss drugs. Not cosmetic drugs. Not simply appetite drugs. In this episode of The ReProgram, Dr. George Murphy launches a new recurring format: The ReProgram Scorecard — a science-first framework for grading popular longevity interventions through the same lens every time:Mechanistic plausibility. Human evidence. Magnitude of likel...

ReProgram Episode 14 AI and Longevity: Hype, Hope, and the Biology of Aging 🧠 Episode Overview What if your doctor could look at your bloodwork, medical history, genome, proteins, metabolites, microbiome, and health trajectory - and tell you more than whether you are sick today? Can artificial intelligence decode human aging? AI will not magically cure aging. It will not replace biology. And it w...

ReProgram Episode 14 The NAD Myth? What the New Human Data Really Say 🧠 Episode Overview In this episode of The ReProgram, Dr. George Murphy takes a critical but balanced look at one of the most popular ideas in the longevity space:That NAD levels decline with age — and that boosting NAD may help slow aging. But new human data challenge one of the most common assumptions behind the NAD story:Whol...

ReProgram Episode 13 🧠 Episode Overview What does it actually mean to measure your biological age—and can it be changed? In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Jesse Poganik, a leading scientist in the field of biological aging clocks and biomarkers of aging. Together, they unpack the science behind biological age—how it’s measured, what it reflects, and whether it...

ReProgram Episode 12 Most people think they need to do more. Train harder. Push further. Add more stimulus. But what if the real problem isn’t effort…What if your body can no longer recover from what you’re already doing? In this episode of The ReProgram, Dr. George Murphy reframes aging, performance, and longevity through a different lens:Recovery capacity. Rather than viewing aging as simple dec...

In this episode of The ReProgram, Dr. George Murphy reframes skeletal muscle as far more than tissue for movement or aesthetics. Muscle is one of the body’s most powerful regulators of metabolic stability, resilience, recovery, and long-term functional independence. This conversation explores why the loss of muscle with age is not simply about weakness—it is a systems-level shift that affects gluc...

In this episode—Part 3 of the Peptides 101 series—we move beyond healing and performance to examine one of the most compelling and misunderstood frontiers in modern medicine: longevity and anti-aging peptides. But this is where the conversation changes. Because using peptides to recover from injury is fundamentally different from using them to modify the trajectory of aging itself. In this episode...

ReProgram Episode 10 In this insightful interview, Dr. Stacy Andersen, a behavioral neuroscientist and expert in aging research, shares her journey into the study of exceptional longevity, the characteristics of centenarians, and the biological and lifestyle factors that contribute to healthy aging. Discover how resilience to disease, genetic protective factors, and lifestyle choices intertwine to...

ReProgram Episode 9 In this episode of the Reprogram podcast, Dr. George Murphy interviews Dr. Nicholas Skivir, an expert in biological aging clocks. They discuss the differences between biological and chronological age, the complexities of measuring aging, and the construction and application of biological aging clocks. The conversation delves into factors influencing biological age, the role of...

In this episode of Peptides 101, Dr. George Murphy delves into the application of peptide science in real-world scenarios, focusing on the distinction between peptides as signals versus supplements. He discusses the compelling nature of healing peptides, particularly BPC 157 and TB 500, and the importance of understanding the scientific evidence behind their use. The conversation emphasizes the ga...

The ReProgram Episode 8A: The first in a 3 part series In this episode, Dr. George Murphy delves into the world of peptides, exploring their scientific basis, the misconceptions surrounding them, and the importance of understanding their structure and function. He discusses the differences between natural and synthetic peptides, the manufacturing process, and the potential risks associated with pe...

The ReProgram Episode 7 In this episode of the Reprogram Podcast, Dr. George Murphy explores the rise of GLP-1 drugs like Ozempic, Wegovy, and Mounjaro, discussing their mechanisms, effects on metabolism, and implications for aging and healthspan. He emphasizes that these drugs are not merely weight loss solutions but agents that act on multiple organs to reprogram how the body regulates energy an...

Episode 6 This episode of the ReProgram podcast, featuring Dr. Benjamin Wolozin, delves into the complexities of neurodegenerative diseases and brain aging, with a focus on Alzheimer's. The discussion covers the diversity of these diseases, diagnostic challenges, and the future of research. The conversation is enriched with personal stories and expert insights, providing a comprehensive unders...

Episode 5 In this episode of the Reprogram podcast, Dr. George Murphy explores the burgeoning world of longevity clinics, particularly in Thailand, where anti-aging treatments have become mainstream. He delves into the science behind stem cell therapies, the rise of IV drip bars, and the booming aesthetic dermatology industry. The conversation highlights the accessibility and affordability of thes...

Episode 4 In this episode of the Reprogram Podcast, Dr. George Murphy hosts Dr. Rozalyn Anderson, a leading expert in caloric restriction and metabolism and how they impact healthful aging. They delve into the science of aging, focusing on caloric restriction and its impact on longevity. Dr. Anderson shares her journey from yeast genetics to studying aging in animal models, and finally, to applyin...

Episode 1 In this episode of the Reprogram podcast, Dr. George Murphy and Dr. Gustavo Mostoslavsky delve into the world of stem cells and regenerative medicine. They discuss the fundamental properties of stem cells, their classifications, and the controversies surrounding their use in treatments. The conversation highlights the groundbreaking discovery of induced pluripotent stem cells (iPSCs) and...

Episode 2 In this episode of the Reprogram podcast, Dr. George Murphy explores the enigmatic topic of aging, discussing its definitions, cultural significance, and the latest scientific advancements aimed at understanding and potentially reversing the aging process. The conversation delves into the historical obsession with aging, the current state of research, and the implications of emerging the...

Episode 3 In this episode of the Reprogram podcast, Dr. George Murphy hosts Dr. Tom Perls, a leading expert in human exceptional longevity. They discuss Dr. Perls' journey into gerontology, the New England Centenarian Study, and the factors contributing to exceptional longevity. The conversation covers the genetic and environmental influences on aging, the role of centenarians in understanding lon...

Episode 0 In the premier episode of The ReProgram podcast, Dr. George Murphy introduces the concept of reprogramming oneself for resilience against disease and disability. He shares his existential crisis about focusing on disease treatment rather than prevention, leading to a new approach centered on studing dynamic resilience, or our ability to robustly respond to insult and injury. The episode...