The ReProgram

🎬 EPISODE OVERVIEW Does your fish oil capsule deserve its reputation? In Episode 31, I review omega-3s for heart health, cognition, and healthy aging, then give five evidence scores and an overall C+.We examine VITAL, REDUCE-IT, STRENGTH, newer DHA research, aging clocks, and safety. Eating fish, taking supplements, and using prescription omega-3s are different questions. 🔑 KEYWORDS Omega-3 • Fi...

🎬 EPISODE OVERVIEW Can a younger clock score translate into better health? In Episode 30, I sit down with Dr. Steve Horvath to explore epigenetic clocks, biological-age claims, and his vision for rejuvenation. We discuss why there are so many clocks, what stands between research and patient care, prevention, and why progress may come one organ at a time .👤 ABOUT THE SPEAKER Dr. Steve Horvath is...

🎬 EPISODE OVERVIEW Why do some animals live so much longer than others—and what can they teach us about healthier human aging? In Episode 29 of The ReProgram, I sit down with Dr. Steve Austad to explore nature’s longevity clues, why women tend to outlive men, and what would count as convincing evidence that an intervention slows aging. We discuss aging “speedometers,” the difference between lifes...

🎬 EPISODE OVERVIEW The Longevity Consortium is mapping the biology of aging. We review the NIH-funded research aiming to delay chronic disease. The NIH-supported Longevity Consortium is a massive effort to understand the biology of aging to reduce risks of cancer, dementia, and frailty. We examine their five core focus areas, ranging from exceptional longevity cohorts to candidate drug screening....

🎬 EPISODE OVERVIEW Could the compound in magic mushrooms influence how we age? Psilocybin research is producing intriguing findings, but changing brain activity, treating depression and extending human life are very different claims. In Episode 27, Dr. George Murphy puts psilocybin through The ReProgram Scorecard. He examines experiments in human cells and aged mice, brain imaging and plasticity...

ReProgram Episode 26: GLP-1 Drugs for Longevity 🎬 EPISODE OVERVIEW A drug millions of people already take extended median lifespan by approximately 12% in older female mice. Does that change the case for GLP-1 drugs as longevity therapies? In this update, Dr. George Murphy reopens The ReProgram Scorecard to examine a new Nature study of late-life semaglutide treatment. He explores the survival fi...

ReProgram Episode 25: 🩸 YOUR BLOOD MAY BE AGING BEFORE YOU ARE 🧠 Episode Overview Blood aging is often overlooked, but the hematopoietic stem cells inside your bone marrow carry a decades-long history. Your blood is not just a fluid; it is a continuously renewing organ system. As the stem cells that manufacture your blood cells age, they can shift immune composition and increase susceptibility t...

Welcome to The ReProgram. Longevity science moves a lot slower than longevity marketing. The ReProgram explores the biology of aging, longevity drugs, regenerative medicine, nutrition, exercise, biotechnology, and the emerging science that may help us live longer, healthier lives. Mechanism over marketing. Evidence over anecdotes. Trade-offs over hype. Understand Aging. Build Resilience. Extend He...

🎬 EPISODE OVERVIEW Every cell in your body contains essentially the same DNA, yet a neuron behaves nothing like a skin cell. So what actually gives a cell its identity — and how permanent is that identity? In this episode, Dr. George Murphy sits down with epigenetics and cellular reprogramming expert Dr. Jose Polo to explore how cells establish identity, how that identity can be rewritten, and wh...

🧠 EPISODE OVERVIEW Creatine is cheap, widely available, and backed by an unusually large body of human research. But its biology extends well beyond the gym. The creatine–phosphocreatine system helps cells rapidly regenerate ATP when energy demand rises—in both muscle and brain. In this episode, we examine the evidence for creatine and muscle preservation, cognition and brain resilience, kidney s...

🐾 EPISODE OVERVIEW This episode asks a deceptively simple question: Can we actually help our dogs and cats live longer, healthier lives? We explore why companion animals are unusually powerful models of aging, why “one dog year equals seven human years” is biologically wrong, what the Dog Aging Project is revealing, what pet owners can reasonably do today, and where emerging interventions like ra...

🧠 Episode Overview Mitochondria are known as the powerhouses of the cell—but energy production is only part of their story. In this episode of The ReProgram, Dr. George Murphy speaks with mitochondrial biologist Dr. Stefan Isaac about mitochondrial DNA, heteroplasmy, stress signaling, mitophagy, genome editing, and the possibility of transferring healthy mitochondria into damaged or aging cells....

🧠 Episode Overview Metformin is inexpensive, widely prescribed, and supported by decades of clinical experience. It is also one of the most frequently discussed drugs in longevity medicine. But does metformin actually slow human aging? In this episode, Dr. George Murphy puts metformin through The ReProgram Scorecard, examining its biological mechanisms, human evidence, safety, accessibility, and...

🧠 Episode Overview What if your age on paper is not the number that matters most? In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Raghav Sehgal at the Gordon Research Conference Systems Aging Meeting in Maine. Dr. Sehgal discusses his work analyzing dozens of putative longevity interventions across epigenetic clocks, why DNA methylation data are uniquely useful for cross-st...

🧠 Episode Overview What if aging is shaped not only by what you eat, how much you exercise, or which genes you inherit — but also by when your body does things each day? In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Mimi Shirasu-Hiza at the Gordon Research Conference Systems Aging Meeting in Maine. Dr. Shirasu-Hiza is a Professor of Genetics and Development at Columbia Un...

🧠 Episode Overview What if “biological age” as a single number is the wrong way to think about aging? In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Rich Miller at the Gordon Research Conference Systems Aging Meeting in Maine. Dr. Miller is a Professor of Pathology at the University of Michigan and one of the leaders of the Interventions Testing Program, the gold standard...

🧠 Episode Overview Are GLP-1 agonists longevity drugs? Not weight loss drugs. Not cosmetic drugs. Not simply appetite drugs. In this episode of The ReProgram, Dr. George Murphy launches a new recurring format: The ReProgram Scorecard — a science-first framework for grading popular longevity interventions through the same lens every time:Mechanistic plausibility. Human evidence. Magnitude of likel...

ReProgram Episode 14 AI and Longevity: Hype, Hope, and the Biology of Aging 🧠 Episode Overview What if your doctor could look at your bloodwork, medical history, genome, proteins, metabolites, microbiome, and health trajectory - and tell you more than whether you are sick today? Can artificial intelligence decode human aging? AI will not magically cure aging. It will not replace biology. And it w...

ReProgram Episode 14 The NAD Myth? What the New Human Data Really Say 🧠 Episode Overview In this episode of The ReProgram, Dr. George Murphy takes a critical but balanced look at one of the most popular ideas in the longevity space:That NAD levels decline with age — and that boosting NAD may help slow aging. But new human data challenge one of the most common assumptions behind the NAD story:Whol...

ReProgram Episode 13 🧠 Episode Overview What does it actually mean to measure your biological age—and can it be changed? In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Jesse Poganik, a leading scientist in the field of biological aging clocks and biomarkers of aging. Together, they unpack the science behind biological age—how it’s measured, what it reflects, and whether it...

ReProgram Episode 12 Most people think they need to do more. Train harder. Push further. Add more stimulus. But what if the real problem isn’t effort…What if your body can no longer recover from what you’re already doing? In this episode of The ReProgram, Dr. George Murphy reframes aging, performance, and longevity through a different lens:Recovery capacity. Rather than viewing aging as simple dec...

In this episode of The ReProgram, Dr. George Murphy reframes skeletal muscle as far more than tissue for movement or aesthetics. Muscle is one of the body’s most powerful regulators of metabolic stability, resilience, recovery, and long-term functional independence. This conversation explores why the loss of muscle with age is not simply about weakness—it is a systems-level shift that affects gluc...

In this episode—Part 3 of the Peptides 101 series—we move beyond healing and performance to examine one of the most compelling and misunderstood frontiers in modern medicine: longevity and anti-aging peptides. But this is where the conversation changes. Because using peptides to recover from injury is fundamentally different from using them to modify the trajectory of aging itself. In this episode...

ReProgram Episode 10 In this insightful interview, Dr. Stacy Andersen, a behavioral neuroscientist and expert in aging research, shares her journey into the study of exceptional longevity, the characteristics of centenarians, and the biological and lifestyle factors that contribute to healthy aging. Discover how resilience to disease, genetic protective factors, and lifestyle choices intertwine to...

ReProgram Episode 9 In this episode of the Reprogram podcast, Dr. George Murphy interviews Dr. Nicholas Skivir, an expert in biological aging clocks. They discuss the differences between biological and chronological age, the complexities of measuring aging, and the construction and application of biological aging clocks. The conversation delves into factors influencing biological age, the role of...