The Optispan Podcast with Matt Kaeberlein

Subscribe to our channel: https://www.youtube.com/@optispan Over a decade ago, five researchers published a paper proposing the Hallmarks of Aging paradigm: a set of cellular and molecular processes that underlie the aging process in different organisms. These hallmarks encompass a range of interconnected pathways, including genomic instability, telomere attrition, epigenetic alterations, loss of...

Subscribe to our channel: https://www.youtube.com/@optispan Everyone has different reactions to medications—you might experience indigestion after taking a new drug, while someone else might feel nothing at all. In this episode, Matt describes his recent experience developing a bacterial infection while taking a course of antibiotics and discusses the importance of being aware of and prepared for...

Subscribe to our channel: https://www.youtube.com/@optispan The Sutphin Lab: https://sutphinlab.org/ University of Arizona Assistant Professor of Molecular and Cellular Biology George Sutphin runs a lab that investigates genetic determinants of longevity, the effects of kynurenine-based interventions on lifespan, and environmental regulators of the aging process. George, who was an aerospace engin...

Subscribe to our channel: https://www.youtube.com/@optispan Everything we talk about on The Optispan Podcast has geroscience at its root, so we decided to make an episode about it. Geroscience is the study of the mechanisms connecting biological aging with disease and disability. The term first appeared in the scientific literature around 2008, and its use has steadily increased since as researche...

Subscribe to our channel: https://www.youtube.com/@optispan Defining "healthspan" & its role in living longer: https://www.youtube.com/watch?v=cI6CNFeBl88 Longevity This Week is a series of episodes discussing new findings or articles relevant to geroscience, longevity, and healthspan that may have popped up in the news. This week we're featuring Richard Morgan, a 93-year-old row...

Subscribe to our channel: https://www.youtube.com/@optispan Understanding Aging & Disease and How They're Related: https://www.youtube.com/watch?v=94_Rqe2m1C0&feature=youtu.be Biological age—that is, how old your cells and tissues are based on physiological function—is a multifaceted and intricate concept that transcends numerical representation. Unlike chronological age, which refers...

Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw Producer: Tara Mei Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of...

Matt and guest Jonathan An, Assistant Professor of Oral Health Sciences at the University of Washington School of Dentistry, discuss oral health and its relationship to aging, including published studies involving rapamycin effects on oral health. This is a 3-part episode. Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw Producer: Tara Mei Video Editor: Jacob K...

Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw Producer: Tara Mei Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of...

Matt and guest Jonathan An discuss oral health and its relationship to aging, including published studies involving rapamycin effects on oral health. This is a 3-part episode. EP 1: Jon's career choices + how he realised aging was important Aging and oral health/potential relationships between periodontal disease and diseases of aging EP 2 (February 14th): The divide between oral health and th...

The R-files is a series of episodes about rapamycin, a naturally occurring compound originally discovered in soil samples from Easter Island, also known as Rapa Nui (hence the drug's name). Rapamycin belongs to a class of drugs called macrolides and has potent immunosuppressive and anti-proliferative effects. The drug has garnered attention for its potential anti-aging properties and has attra...

Matt and guest Jonathan An discuss oral health and its relationship to aging, including published studies involving rapamycin effects on oral health. This is a 3-part episode. EP 1: Jon's career choices + how he realised aging was important Aging and oral health/potential relationships between periodontal disease and diseases of aging EP 2 (February 14th): The divide between oral health and th...

Optispan CEO Matt Kaeberlein discusses common assumptions about longevity and healthspan. Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw Producer: Tara Mei Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as,...

Check out Prime Health Associates for personalized healthcare solutions: https://www.primehealthassociates.com/ Optispan CEO Matt Kaeberlein chats with Prime Health Associates Physician Kevin White about making the transition from research to building a company, moving towards preventative medicine in the 21st century, incorporating new discoveries into medical practice, and more. Watch our episod...

Optispan CEO Matt Kaeberlein discusses common assumptions about longevity and healthspan. Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw Producer: Tara Mei Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as,...

Check out Prime Health Associates for personalized healthcare solutions: https://www.primehealthassociates.com/ Optispan CEO Matt Kaeberlein chats with Prime Health Associates Physician Kevin White about making the transition from research to building a company, moving towards preventative medicine in the 21st century, incorporating new discoveries into medical practice, and more. Watch our episod...

Check out Prime Health Associates for personalized healthcare solutions: https://www.primehealthassociates.com/ Optispan CEO Matt Kaeberlein chats with Prime Health Associates Physician Kevin White about making the transition from research to building a company, moving towards preventative medicine in the 21st century, incorporating new discoveries into medical practice, and more. Watch our episod...

Optispan CEO Matt Kaeberlein takes questions about healthy aging. Watch our episodes with video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw Producer: Tara Mei Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical a...