The Optispan Podcast with Matt Kaeberlein

Help keep the Dog Aging Project alive (prizes available!): https://donor-list.org/go/QGkYGQcLFL More about the Dog Aging Project: https://dogagingproject.org/ Enroll your dog in the Dog Aging Project: https://redcap.dogagingproject.org/su... The Dog Aging Institute: dogaginginstitute.org Save the Dog Aging Project! In 2014, Matt co-founded the Dog Aging Project, an ambitious, large-scale study of...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: The Surprising Way Body Size Relates to Lifespan: https://youtu.be/Fjh6WbkZkvw Comparing Bryan Johnson's RAPAMYCIN DATA: INTERESTING RESULTS: https://youtu.be/1-ZKzfQDQYk Reversing Biological Age: Have we finally found the answer?: https://youtu.be/ivP3QTyQ2d4 We've hit 6,000 subscribers! To celebrate this milest...

Subscribe to our channel: https://www.youtube.com/@optispan In this episode, we discuss three findings that have made the rounds in the geroscience and healthspan spaces in recent months. They relate to three universally-relevant topics: pregnancy, exercise, and diet. The first study suggested that women who have been pregnant at least once age faster than women who had never been pregnant, contro...

Subscribe to our channel: https://www.youtube.com/@optispan Is bigger always better? It depends. Throughout the human lifespan, body size plays an important role in determining health outcomes and quality of life. It's not just about body mass index, fat distribution, weight, or muscle mass: there also exists a relationship between body size and longevity across multiple species, including hum...

Subscribe to our channel: https://www.youtube.com/@optispan Resveratrol is a naturally occurring polyphenolic compound found in various plants, including in the skins of grapes, blueberries, raspberries, mulberries, and peanuts. Its association with red wine has contributed to the illusion of the "French Paradox": the observation that French people have a relatively low incidence of hear...

Subscribe to our channel: https://www.youtube.com/@optispan The journey towards prioritizing one's healthspan can be a circuitous path full of triumphs, setbacks and lessons. Challenges arise and old habits rear their ugly heads. Unforeseen obstacles test our resolve. The road is rarely linear and often leads us to unexpected places. In this episode, Matt chats with former Microsoft Chief Tech...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: The R-Files episode 1: https://youtu.be/czx_-DqnnrQ The R-Files episode 2: https://youtu.be/EgIy0ghrDmo The R-Files episode 3: https://youtu.be/jLV5nOenD-g The R-Files episode 4: https://youtu.be/6AjKOe-yZeM Matt Kaeberlein's ALLERGIC REACTION to Medication While on Rapamycin: https://youtu.be/6vIVj4SaBx4 Are DEXA sc...

Subscribe to our channel: https://www.youtube.com/@optispan Matt recently exchanged a lively correspondence about biological age with Harold Katcher, cofounder of a stealth biotechnology company and inventor of E5. E5 is a compound consisting of the purified exosome fraction of blood from young piglets—in other words, young pig blood. Harold recently co-published a paper suggesting that injecting...

Subscribe to our channel: https://www.youtube.com/@optispan Support the Longevity Million Molecule Challenge: https://orabiomedical.com/shop/ No single discipline or approach holds the key to making big strides in the longevity field. Human aging is incredibly complex, and we're going to need multiple shots on goal in our pursuit of human life- and healthspan extension. At the Optispan Podcast...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: https://youtu.be/YhzgYaY7wto In April 2024, Matt delivered a presentation at a two-day congressional briefing on longevity science hosted at Washington, D.C.'s Mayflower Hotel by the Alliance for Longevity Initiatives (A4LI). Attendees included former Speaker of the House Newt Gingrich, Republican Congressman Gus Bil...

Subscribe to our channel: https://www.youtube.com/@optispan We talk a lot about the science of longevity and healthspan on the Optispan podcast—how DEXA scans work, what an optimal rapamycin dose might look like, how the intersection of optogenetics and mitochondria are helping us understand biological aging, what supplements one might consider taking and why. But the longevity field runs on way m...

Subscribe to our channel: https://www.youtube.com/@optispan Related videos: The Importance of Body Composition & Ways YOU can measure it | 21 - HSM #3: https://youtu.be/gM3aYTMsqNI A DEXA (dual-energy X-ray absorptiometry) scan is an advanced imaging procedure for measuring bone density and composition. DEXA scans utilize two different energy levels of low-dose X-ray beams—one absorbed mostly...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: The Importance of Body Composition & Ways YOU can measure it | 21 - HSM #3: https://youtu.be/gM3aYTMsqNI We talk a lot about making a shift from reactive disease care—a 20th century healthcare mindset—to preventative and proactive health measures designed to optimize longevity and healthspan before disease sets in. R...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: People are GETTING THIS WRONG about Supplements & My Supplement List | 17 - Healthspan Medicine #2: https://youtu.be/_UXk_ynCNUs Transforming Our Understanding of Healthcare Through Geroscience | 11 - LS #4: https://youtu.be/LCPvF-SlZIU We typically think of prescription drugs as targeted treatments designed to addre...

Subscribe to our channel: https://www.youtube.com/@optispan Senescent cells, cells that cease to divide and proliferate while remaining metabolically active, are a complex and intriguing aspect of biological aging. They serve as both a protective mechanism against cancer, preventing damaged cells from uncontrollable replication, as well as a contributor to tissue dysfunction and age-related pathol...

Subscribe to our channel: https://www.youtube.com/@optispan The R-Files episode 1: https://youtu.be/czx_-DqnnrQ The R-Files episode 2: https://youtu.be/EgIy0ghrDmo The R-Files episode 3: https://youtu.be/jLV5nOenD-g The R-Files episode 4: https://youtu.be/6AjKOe-yZeM You asked, we listened. Ever since the February 2024 launch of our series "The R-Files", a series of episodes about all th...

Subscribe to our channel: https://www.youtube.com/@optispan Part I: https://youtu.be/-ujIfZXGbDA At the Optispan Podcast, we aim to help you become your own detective of research in the geroscience field and beyond. Critical thinking is our compass. We want to help you dig into every aspect of a study: are the methods they used solid? Was the sample size big enough? Did they crunch the numbers rig...

Subscribe to our channel: https://www.youtube.com/@optispan When drug development companies promote their products, they understandably highlight the benefits and potential relief they offer. While these advertisements can make the products seem like game-changers for health issues, it's important not to swallow the marketing spiel whole. Question it, test it, poke and prod it to see if it hol...

Subscribe to our channel: https://www.youtube.com/@optispan The R-Files episode 1: https://www.youtube.com/watch?v=czx_-DqnnrQ&t=1675s The R-Files episode 2: https://www.youtube.com/watch?v=EgIy0ghrDmo&t=140s The R-Files episode 3: https://www.youtube.com/watch?v=jLV5nOenD-g&feature=youtu.be The R-Files is a series of episodes about rapamycin, a naturally occurring compound originally...

Subscribe to our channel: https://www.youtube.com/@optispan As a longevity scientist, Matt often receives questions about what supplements he takes—so we decided to make an episode where Matt discusses his supplements protocol. This episode isn't meant to provide a playbook for you to follow. We want to emphasize the importance of approaching supplements with discernment and an understanding t...

Subscribe to our channel: https://www.youtube.com/@optispan While scientific papers are generally considered trustworthy sources of information, it's important to approach them with a critical mindset and to avoid blindly accepting their claims. The peer-review process, which helps ensure high research quality, is not foolproof. Errors or biases can slip through the cracks. In reading a paper,...

Subscribe to our channel: https://www.youtube.com/@optispan At its best, healthcare isn't just about extending lifespan—it's also about enhancing the vitality of our years. Over the last century, the healthcare system has made enormous strides in keeping sick people alive. The next step is to use proactive, preventative healthcare to stop them from getting sick at all. The Lost Decade—the...