The Information Bottleneck

In this episode, we talked with Dimitris Papailiopoulos, researcher at Microsoft Research's AI Frontiers lab and professor at the University of Wisconsin, about doing research in the age of agents. Dimitris told us about the Sunday morning that changed how he works: he handed Claude Code and Codex a question he'd been sitting on for years, went about his day, and came back to an answer. After a fe...

Phillip Isola, professor at MIT, joins us to talk about representation learning: what makes a representation good, why different models seem to converge on similar representations, and whether pre-training is really over. We discuss the platonic representation hypothesis and its limits, why clustering structure matters more than global geometry, and Phillip's new neural thickets paper arguing that...

Most AI-for-science companies are selling shovels. Qichao Hu wants the gold. In this episode, we talk with Qichao, the founder and CEO of Molecular Universe, the AI-for-science platform that grew out of SES AI, a high-energy-density battery developer he's run for fourteen years. His core distinction is that companies from the AI world build tools, such as foundation models that predict properties,...

We talk a lot on this show about RL, agents, and the move between pre-training and post-training, but not enough about the layer everything actually runs on. Benny Chen, co-founder of Fireworks AI, one of the largest inference platforms around, walks us through what it takes to serve models at scale: sourcing GPUs, writing the kernels, the runtime, and the routing layer that lets a customer hit on...

Oded Rechavi is a biologist at Tel Aviv University and the co-founder of QED, a company building AI to review scientific work. He's also spent years studying worms. We start with what's wrong with peer review and grant funding: why it takes years to publish, why reviewers are often your own competitors, and why the whole thing is locked to an economic model that rewards publishing more papers, not...

Will AI take our jobs? We put the question to Alex Imas, the new Director of AGI Economics at Google DeepMind and a professor at Chicago Booth, whose entire job now is studying how frontier AI reshapes the economy. His short answer: probably some of them, but the popular story is mostly wrong about which jobs and how fast. Alex makes the case that a job is a bundle of tasks, not a single thing AI...

In this episode, we sit down with Wenhu Chen, research scientist at Meta MSL, assistant professor at the University of Waterloo, and the person behind MMLU-Pro and MMMU. If you've read a frontier model release in the last two years, you've seen his benchmarks. That makes him one of the best people to answer the question everyone dances around: when a model jumps from 40% to 90% on your benchmark,...

In the second half of our conversation with Jürgen Schmidhuber, we focus on the key ideas he's pursued since the early 1990s and discuss why he believes these concepts are only now being rediscovered. We start with JEPA. Jürgen argues that the method LeCun named in 2022 is the same family he published in 1992 as Predictability Maximization. From there he traces the adversarial lineage back further...

In this episode, we host Jürgen Schmidhuber - the man, the legend, one of the godfathers of modern AI. His lab worked out many ideas behind today’s systems (LSTM, world models, artificial curiosity, Transformer variants, and even GAN-style setups) decades before they became fashionable, and he’s just as well known for making sure people remember who did what first. This is the first of two convers...

In this episode, we sit with Max Welling, Professor of Machine Learning at the University of Amsterdam, co-founder and CTO of CuspAI, and a foundational figure behind variational autoencoders (VAEs), equivariant networks, and Bayesian deep learning. We talk about AI for science, the physics underneath generative models, and what's still missing on the road to real intelligence. Max starts with wha...

Julia Kempe on Why Math Will Fall Next, Superhuman Provers, and the Return of the Renaissance Researcher In this episode, we sit down with Julia Kempe, a Professor at NYU's Center for Data Science and researcher at Meta FAIR's Foundations of Reasoning team,  for a wide-ranging conversation on the future of AI research. We dig into why verifiable domains like mathematics may be on track to "fall" t...

We talk with Mengye Ren , Assistant Professor at NYU's Center for Data Science, about what intelligence actually means once you step outside a benchmark, and why scaling a single centralized model isn't the whole story. We get into why intelligence has to be defined in open environments, not closed ones, and what that means for how we measure progress. We push on the creativity question: today's m...

We host Tal Linzen, Associate Professor at NYU and Research Scientist at Google, for a conversation on the intersection of cognitive science and large language models. We discussed why children can learn language from around 100 million words while LLMs need trillions, and the surprising finding that as models get better at predicting the next word, they become worse models of how humans actually...

We host Chieh-Hsin (Jesse) Lai, Staff Research Scientist at Sony AI and visiting professor at National Yang Ming Chiao Tung University, Taiwan, for a conversation about diffusion models, the technology behind tools like Stable Diffusion, and most of the AI image and video generators you've seen in the last few years. Jesse recently co-authored The Principles of Diffusion Models with Stefano Ermon,...

We talked with Christian Szegedy, co-inventor of Inception and Batch Normalization, founding scientist at xAI, now at Math Inc, about what it takes to build a frontier lab, and why he left xAI to work on formal mathematics. Christian thinks Lean and auto-formalization are the missing piece for trustworthy AI: a machine-checkable layer underneath all reasoning, where proofs are guaranteed correct w...

We sat down with Rao Kambhampati, a Professor of CS at Arizona State University and former President of AAAI, to talk about reasoning models: what they are, when they work, and when they break. Rao has been working on planning and decision-making since long before deep learning, which makes him one of the most grounded voices on what today's reasoning systems actually do. We start with definitions...

In this episode, we hosted Zhuang Liu , Assistant Professor at Princeton and former researcher at Meta, for a conversation about what actually matters in modern AI and what turns out to be a historical accident. Zhuang is behind some of the most important papers in recent years (with more than 100k citations): ConvNeXt (showing ConvNets can match Transformers if you get the details right), Transfo...

We talked with Sasha Rush , researcher at Cursor and professor at Cornell, about what it actually feels like to we in the heart of the AI revolution and build coding agents right now. Sasha shared how these systems are changing day-to-day work and how it feels to develop these systems. A big part of the conversation was about why coding has become such a powerful setting for these tools. We discus...

How Denoising Secretly Powers Everything in AI Peyman Milanfar is a Distinguished Scientist at Google, leading its Computational Imaging team. He's a member of the National Academy of Engineering, an IEEE Fellow, and one of the key people behind the Pixel camera pipeline. Before Google, he was a professor at UC Santa Cruz for 15 years and helped build the imaging pipeline for Google Glass at Googl...

Yaroslav Bulatov helped build the AI era from the inside, as one of the earliest researchers at both OpenAI and Google Brain. Now he wants to tear it all down and start over. Modern deep learning, he argues, is up to 100x more wasteful than it needs to be  -  a Frankenstein of hacks designed for the wrong hardware. With a power wall approaching in two years, Yaroslav is leading an open effort to r...

We talk with Kyunghyun Cho, who is a Professor of Health Statistics and a Professor of Computer Science and Data Science at New York University, and a former Executive Director at Genentech, about why healthcare might be the most important and most difficult domain for AI to transform. Kyunghyun shares his vision for a future where patients own their own medical records, proposes a provocative ide...

In this episode, we talk with Stefano Ermon,  Stanford professor, co-founder & CEO of Inception AI, and co-inventor of DDIM, FlashAttention, DPO, and score-based/diffusion models, about why diffusion-based language models may overtake the autoregressive paradigm that dominates today's LLMs. We start with the fundamental topics, such as what diffusion models actually are, and why iterative refi...

Naomi Saphra, Kempner Research Fellow at Harvard and incoming Assistant Professor at Boston University, joins us to explain why you can't do interpretability without understanding training dynamics,  in the same way you can't do biology without evolution. Naomi argues that many structures researchers find inside trained models are vestigial, they mattered early in training but are meaningless by t...

Stefano Soatto, VP for AI at AWS and Professor at UCLA, the person responsible for agentic AI at AWS, joins us to explain why building reliable AI agents is fundamentally a control theory problem. Stefano sees LLMs as stochastic dynamical systems that need to be controlled, not just prompted. He introduces "strands coding," a new framework AWS is building that sits between vibe coding and spec cod...

Tanishq Abraham , CEO and co-founder of Sophont.ai , joins us to talk about building foundation models specifically for medicine. Sophont is trying to be something like an OpenAI or Anthropic but for healthcare  - training models across pathology, neuroimaging, and clinical text, to eventually fuse them into one multimodal system. The surprising part: their pathology model trained on 12,000 public...