The Fundamentals

On this episode of The Fundamentals, we talked to physician scientist, Dr. Monalisa Ghosh, assistant professor of medical oncology and internal medicine, who is looking to expand CAR-T's application from cancer to autoimmune disorders and beyond. Episode Transcript Be sure to check out our second launch episode and our entire back catalog on The Fundamentals website , or on your favorite podcast p...

Season four of The Fundamentals is here, and we're celebrating by doing a special two-episode release to launch the season! On this episode of the Fundamentals, we talked to Professor Kayte Spector-Bagdady, the George E. Wantz Professor of Bioethics, about the use of massive amounts of data, artificial intelligence, and more.  Episode Transcript Be sure to check out our second launch episode...

Season four of The Fundamentals is here, and we're celebrating by doing a special two-episode release to launch the season! On this episode of The Fundamentals, we talk to two clinician scientists determined to unlock the mysteries of idiopathic pulmonary fibrosis. Dr. Marc Peters-Golden and his mentee, Dr. Sean Fortier, discuss their research and the race to uncover the hidden causes of IPF to of...

In today's episode of The Fundamentals, we talk with Dr. John Ayanian, director of the U-M Institute for Healthcare Policy and Innovation . Dr. Ayanian's research explores underlying factors that contribute to persistent health disparities between minoritized groups and their white counterparts, as well as strategies for ending inequity in health care and improving overall health outcomes for ever...

Recently, interest in psychedelic research has seen a resurgence, strengthened by better designed and controlled clinical trials and the use of neuroimaging, examining psychedelics' potential therapeutic use for PTSD, addiction, anxiety, and depression. On today’s episode, we talk with Dr. George Mashour, professor of anesthesiology and pharmacology and founder of the Michigan Psychedelic Center a...

There are an estimated 86 billion neurons in the human brain. Neuroscientists are actively exploring the importance of single or small groups of neurons versus networks of billions of neurons in the processing of sensory information, storage of memories, generation of movement, and everything else the brain does. Until recently, it simply wasn't possible to study billions of neurons at once. In to...

People with diabetes often have a host of other conditions including cardiovascular disease and kidney disease driven by inflammation. On today's episode, we talk with Dr. Katherine Gallagher, professor of surgery, professor of microbiology and immunology, and the Leland Ira Doan Research Professor of Vascular Surgery at U of M, who is looking at how epigenetics - the influence of environmental fa...

Today on The Fundamentals, we have a conversation with Dr. Sonya Wolf-Fortune, Assistant Professor of Pharmacology, whose work focuses on investigating the underlying mechanisms of psoriasis, diabetes, and other inflammatory conditions. Dr. Wolf-Fortune is trying to uncover what sets off the cascades of inflammation related to these conditions and related diseases. Episode Transcript Dr. Wolf-Fort...

A recent University of Michigan study found that around 20% of cervical cancer cases and cervical cancer-related deaths could be avoided if every eligible person was screened. U-M researcher, Dr. Diane Harper is hoping to lower the barriers to cervical cancer screening by making it more convenient and less expensive. How? By empowering patients with the tools and knowledge needed to collect their...

The main cause of death due to opioid overdose is respiratory depression. In other words, the brain of a person under the influence of opioids can simply forget to breathe. In today’s episode, we talk with Dr. Erica Levitt, associate professor in the Departments of Pharmacology and Anesthesiology at University of Michigan Medical School, who is trying to explain this connection, with the hope of m...

Welcome to Season 3 of The Fundamentals. We're starting this season with a conversation about AI: How could AI potentially revolutionize healthcare delivery? The application of computer algorithms to medical knowledge has a long history, one that has accelerated in recent years to include generative AI platforms like ChatGPT. U-M expert Dr. Cornelius James discusses how AI is touching everything f...

On today’s The Fundamentals is Dr. Brummett, Professor at the University of Michigan where he serves as the Senior Associate Chair for Research in the Department of Anesthesiology. He has more than 280 publications, including articles in top journals such as JAMA, JAMA Surgery, Anesthesiology, and Annals of Surgery. He is the Co-Director of the Opioid Prescribing Engagement Network or OPEN at the...

Today on The Fundamentals is Dr. Maria Castro, the R.C. Schneider collegiate professor of neurosurgery, and a professor of cell and developmental biology at the University of Michigan Medical School. Her research program aims to develop immunotherapies for primary and metastatic brain cancer, studying basic immune biology mechanisms leading to clinical implementation. She has been inducted into th...

Today on The Fundamentals is Dr. Kevin Boehnke, research assistant professor in the Department of Anesthesiology and the Chronic Pain and Fatigue Research Center . His current research focuses on therapeutic applications of cannabis and psychedelics. His goal is to rigorously assess appropriate use of these substances and to help address the public health harms caused by their criminalization. You...

Dr. Jody Platt. She is an Associate Professor of Learning Health Sciences at the University of Michigan Medical School. Trained in medical sociology and health policy, her research focuses on issues at the intersection of informatics and ethics. She is interested in understanding what makes data-driven health trusted, and the pathways for earning, achieving, and sustaining trust across stakeholder...

Today on The Fundamentals, our guest Dr. Martin Myers, Director of the U-M Elizabeth Weiser Caswell Diabetes Institute , discusses diabetes research in the context of Ozempic, Wegovy, and other drugs that are changing how people think about weight loss. You can learn more about Dr. Myers here , and you can follow the department of molecular and integrative physiology @UMPhysiology on X. You can le...

Today on The Fundamentals, our guest is Dr. Michelle Kahlenberg, an Associate Professor of Internal Medicine and Dermatology, the Giles Bole and Dorothy Mulkey Research Professor of Rheumatology and the Vice Chair for Basic and Translational Research in Internal Medicine. Her clinical work is centered on the care of patients with lupus, including those with refractory skin disease. In addition to...

Today on The Fundamentals, our guest is Dr. Julie Lumeng, the associate dean for research at the University of Michigan Medical School, executive director of the Michigan Institute for Clinical and Health Research, and the associate vice president for Clinical and Human Subjects Research for the university. She's also a professor in the departments of pediatrics and nutritional sciences, providing...

Today on The Fundamentals, our guest is Dr. Pooja Lagisetty, an assistant professor of internal medicine and a research scientist at the Center for Clinical Management and Research at the Ann Arbor VA. Her research focuses on addressing access barriers and developing multidisciplinary interventions to better treat chronic pain and addiction across general medical settings. Her research has been in...

Today on The Fundamentals, our guest is Dr. Jessica Anand, a research assistant professor in the Department of Pharmacology at the University of Michigan Medical School, and a co-chair of the Pharmacology's Diversity, Equity and Inclusion Committee. Her work focuses on developing new molecules to treat different medical needs, like pain with reduced addiction risk, overdose, and potentially mood p...

Today on The Fundamentals, our guest is Dr. Geoffrey Siwo, a research assistant professor in the University of Michigan Medical School’s Department of Internal Medicine and Research Associate at the Michigan Center for Global Health Equity. His research focuses on accelerated and equitable innovation, using emerging computational technologies such as artificial intelligence, programmable biotechno...

Today on The Fundamentals, we talk with Dr. Ariangela Kozik, an assistant Professor in Molecular, Cellular, and Developmental Biology at the University of Michigan, and member of U-M Precision Health. Dr. Kozik's primary work involves conducting translational microbiome research to understand inflammatory diseases. Her interests also include the application of biopsychosocial models of diseas...

In our inaugural episode of The Fundamentals, we talk with Dr. Steven Kunkel about why he chose to build his now 40+ year career at the University of Michigan, why U-M’s research community is so special, the Great Minds Greater Discoveries strategic research initiative, and more. You can learn more about The Fundamentals on our website . A transcript of this episode can be found here . Find out mo...

Welcome to The Fundamentals, a podcast where we explore biomedical research here at Michigan Medicine–and meet the scientists behind it. Research is fundamental to the University of Michigan’s mission to improve the world. You can learn more about The Fundamentals on our website . A transcript of this episode can be found here . The Fundamentals is a part of the Michigan Medicine Podcast Network ,...