The Clinical Chronicle

Welcome to Season 2, Episode 1 of The Clinical Chronicle. This episode delivers major practice-changing updates in medicine for 2026, including the new AHA and ASA acute ischemic stroke guideline, evolving evidence on sodium correction in severe hyponatremia, and why current lung cancer screening criteria may be missing more than 60 percent of patients at diagnosis. We break down expanded eligibil...

From blood-based diagnostics and durable disease-modifying therapy in Alzheimer’s disease to age-dependent cardiovascular protection with GLP-1 and SGLT2 therapies, this episode captures the most practice-changing advances of 2025. We unpack 10 high-impact updates, including expanded SGLT2 use across the full spectrum of chronic kidney disease, CDC-endorsed twice-yearly injectable HIV prevention,...

From targeted therapies in HER2-mutant lung cancer to the latest Alzheimer’s data with Kisunla, this month’s breakthroughs could reshape patient care. We unpack 10 high-impact studies and trials, including new insights on ILD–cancer links, the HOPE trial in late-window stroke thrombolysis, phenotype-specific benefits of CPAP, and kidney-protective strategies in diabetic CKD. Designed for clinician...

From a once-monthly GLP-1/GIP driving 16% weight loss to a twice-yearly HIV PrEP injection, this episode unpacks the most practice-changing updates in internal medicine. We cover new evidence in obesity care, MASH reversal, stroke anticoagulation timing, sarcoidosis management, COPD biologics, and the cardioprotective power of oral semaglutide. Plus, hear what every rising PGY-2 should know headin...

From FIT screening outpacing colonoscopy in participation to anti-CD20 drugs showing lasting MS control at 7+ years, this edition brings clarity to complex clinical choices. We examine how metabolic syndrome increases young-onset dementia risk by 24%, why post-ERCP pancreatitis rates haven’t budged in two decades, and the unchanged survival edge between IO and IV access in cardiac arrest. As phtha...