Surfing the MASH Tsunami

Send us Fan Mail Healthy Livers, Healthy Lives Chair Jeff Lazarus joins Jörn Schattenberg, Louise Campbell and Roger Green to discuss some of the specific structural challenges that confront global MASLD public policy, along with some promising local activities. Louise observes that, in her experience, primary care practitioners appreciate the support that specialist nurses can bring in educating...

Send us Fan Mail Healthy Livers, Healthy Lives Chair Jeff Lazarus joins Jörn Schattenberg, Louise Campbell and Roger Green to discuss why political will is so important in overcoming inertia and obstruction in global MASLD public health policy. Louise notes that she left NHS because of obstruction against earlier stage efforts to promote liver health and asks how to achieve these goals. To Jeff, i...

Send us Fan Mail Healthy Livers, Healthy Lives Chair Jeff Lazarus joins Jörn Schattenberg, Louise Campbell and Roger Green to discuss how the coalition came into existence and to describe two initiatves aimed at increasing early screening. Jeff starts the conversation by describing the "bit of a bubble" in which the MASLD community lives: great news and lots of excitement within, but ver...

Send us Fan Mail 00:00:00 - Surf's Up: Season 5 Episode 22   Jeff Lazarus joins Jörn Schattenberg, Louise Campbell and Roger Green to discuss Healthy Livers, Healthy Lives, a coalition of four major professional organizations (AASLD, ALEH, APASL and EASL) and other partners. This coalition works with other specialties to create global public health awareness and drive "top-down" sol...

Send us Fan Mail This week's vault conversation looks back 17 months when Ken Cusi joined co-hosts Louise Campbell, Jörn Schatenberg and Roger Green to discuss the revised AASLD Practice Guidance that had been issued the previous week. At the time, here was SurfingMASH's summary of the conversation: Late last week, AASLD published new practice guidance on the clinical assessment and mana...

Send us Fan Mail In this closing conversation, updated MASLD CPG co-authors Frank Tacke and Elisabetta Bugianesi and podcast co-hosts Louise Campbell and Roger Green consider what the guidelines might foretell in changes in provider education, structure of patient visits and treatment in less affluent or medically advanced countries. The last set of questions begins with Roger asking what kinds of...

Send us Fan Mail For most of this conversation, updated MASLD CPG co-authors Frank Tacke and Elisabetta Bugianesi discuss key issues related to pharmacology and prescribing choices. At the end, the focus shifts to the guidelines' overall benefits and some new kinds of education they call for.  The conversation starts with co-host Roger Green asking about key issues from the pharmacology secti...

Send us Fan Mail In this conversation, updated MASLD CPG co-authors Frank Tacke and Elisabetta Bugianesi discuss some of the guidelines' key goals and issues surrounding the screening, diagnosis and management of MASLD patients.  As the conversation starts, co-host Roger Green says that he, too, was impressed that all these adjustments were made within a month at the end of the process. Frank...

Send us Fan Mail In this conversation, updated MASLD CPG co-authors Frank Tacke and Elisabetta Bugianesi explain how the guidelines process benefitted from the close collaboration between EASL, EASD, and EASO.   The conversation starts with Elisabetta conveying the "big advantage" that came from this collaboration. The presence of the three organizations conveyed the need to create a com...

Send us Fan Mail Two of the co-authors of the upgraded MASLD Clinical Practice Guidelines,  Elisabetta Bugianesi and Frank Tacke join Louise Campbell and Roger Green to discuss the guidelines.  The theme for the conversation is "introductions". First, the audience is introduced to co-authors Elisabetta Bugianesi and Frank Tacke, neither of whom has Surfed the Tsunami before. Both Elisabe...

Send us Fan Mail 00:00:00 - Surf's Up: Season 5 Episode 21  One important session at the EASL Congress 2024 involved the presentation of the new MASLD Clinical Practice Guidelines. CPG co-authors Elisabetta Bugianesi and Frank Tacke join Louise Campbell and Roger Green to share their perspectives on the guidelines' development some key recommendations.   00:09:36 - Revising the guideline...

Send us Fan Mail In this conversation from July 2023, Stephen Harrison, Jörn Schattenberg and Roger Green discuss the implications of presentations on the FGF-21 agent efruxifermin and the dual GLP/glucagon agonists pemvidutide and efinopegdutide.  Here is the description Roger wrote for the original conversation: In this session, conversation shifts from resmetirom to Mazen Noureddin's &quot...

Send us Fan Mail Mazen Noureddin and Naim Alkhouri join Jörn Schattenberg and Roger Green to discuss some of the other major drug development stories from the EASL Congress 2024, with special focus on denifenstat, ION-224 and TAK-227, and to review the SPECIAL study on bariatric surgery and cirrhosis.  The panelists concur that all three of these agents have potential value in therapy. Naim expres...

Send us Fan Mail Mazen Noureddin and Naim Alkhouri join Jörn Schattenberg and Roger Green to focus on the role FGF-21s will play in long-term advanced fibrosis treatment: induction or long-term therapy...or might we even think of the class as being able to produce a "MASH cure?"  Responding to Naim's comment closing the previous discussion, Mazen questions why we regard FGF-21 agent...

Send us Fan Mail Naim Alkhouri and Mazen Noureddin join Jörn Schattenberg and Roger Green to discuss issues regarding incretin agonists and results from the efruxiermin late-breaker at the EASL Congress 2024. Naim shares his general excitement about glucagon agents in general. He mentions that the efinopegdutide study included a semaglutide cell, which showed further reduction in liver fat vs. the...

Send us Fan Mail Mazen Noureddin and Naim Alkhouri join Jörn Schattenberg and Roger Green to discuss the tirzepatide late-breaker at the EASL Congress 2024 and other "Twin-cretins," all of which are GLP-glucagon combinations.  "Twin-cretins" is the name Jörn has coined for agents with a GLP-1 agonist plus another incretin effect. Tirzepatide is a GLP/GIP agent, while survodutid...

Send us Fan Mail Naim Alkhouri and Mazen Noureddin join Jörn Schattenberg and Roger Green to discuss some of the new research on resmetirom at the EASL Congress 2024. Mazen begins this discussion by covering a paper he presented on Stephen's behalf, looking at dose-response with resmetirom. The analysis indicated that PDFF and histology improvements at the 100mg dose were greater than at the...

Send us Fan Mail 00:00:00 Surf's Up, Season 5 Episode 20 Naim Alkhouri and Mazen Noureddin join co-hosts Jörn Schattenberg and Roger Green to discuss major drug development stories from the EASL Congress 2024. They pay tribute to Stephen Harrison and proceed to groundbreakers. 00:08:16 - Presentations on Resmetirom Mazen shares a paper he presented looking at resmetirom dose-response. The 100...

Send us Fan Mail 00:00:00 - Surf's Up: Season 5 Episode 19 During EASL Congress 2024, US-based Roger Green, conducted interviews with Mike Betel, Louise Campbell (twice) and Sven Francque from Milano. These interviews focused on the major MASLD themes and presentations at the event.  00:04:14 - Conversation with Mike Betel begins On Wednesday, the first afternoon of the meeting, Mike Betel jo...

Send us Fan Mail In this final conversation, Sober Livers leaders Jenn Jones and Beth Lehman share what they hope listeners will take from this discussion of HOPE ( H ealing O thers with P eers and E ducation) and how they can help this unique support program grow.  The conversation starts with Roger asking what Sober Livers and/or transplant centers can do to help patients learn how to find a liv...

Send us Fan Mail Sober Livers leaders Jenn Jones and Beth Lehman join Roger Green to discuss HOPE, their new support community for people who have harmed themselves through AUD ( A lcohol U se D isorder). This conversation focuses on plans and hopes for the future. Roger starts this conversation by sharing a story from his own experience about the pressure caregivers struggle with and asks how HOP...

Send us Fan Mail In this conversation, Society of Sober LIvers leaders Jenn Jones and Beth Lehman describe the HOPE ( H ealing O thers with P eers and E ducation) program. They go on to discuss  why version 1.0 does not include specific support for caregivers. Jenn describes the program's core elements, starting with a monthly video call that is a support meeting one month and an educational...

Send us Fan Mail This conversation focuses on the target population of patients with AUD ( A lcohol U se D isorder) with decompensated cirrhosis and asks why this group needs a support community like HOPE ( H ealing O thers with P eers and E ducation). Roger asks what makes people who have harmed their bodies through AUD a unique community as compared to other communities providing support for peo...

Send us Fan Mail This conversation re-introduces us to Sober Livers Founder/Visionary Jenn Jones and introduces us to Beth Lehman, Principal Strategic Advisor to Sober Livers and HOPE, a multi-element patient support program for people who have harmed their livers though AUD ( A lcohol U se D isorder). As this conversation starts, we meet Beth Lehman, Principal Strategic Advisor for Sober LIvers,...

Send us Fan Mail Roger Green is joined by Sober Livers Founder/Visionary Jenn Jones and Principal Strategic Advisor Beth Lehman to discuss HOPE, a support program launching June 11 for people who have harmed their bodies through ALD and its consequences.  00:00:00 - Surf's Up: Season 5 Episode 18 Standard lead-in, including quotes from panelists 00:02:07 - Introduction Roger describes the epi...