Sit. Stay. Learn. with Dr. Adrienne Wright

Can orthobiologics outperform steroids in equine osteoarthritis treatment? In Episode 11 of Sit. Stay. Learn. , Dr. Adrienne Wright reviews the 2020 paper “Effects of Autologous Conditioned Serum, Autologous Protein Solution, and Triamcinolone on Inflammatory and Catabolic Gene Expression in Equine Cartilage and Synovial Explants Treated with IL-1β in Co-culture” and breaks down how ACS, APS, and...

Cancer affects far too many dogs, and better treatment options are urgently needed. In Episode 10 of Sit. Stay. Learn. , Dr. Adrienne Wright reviews the paper “Autologous Cancer Vaccines: A Precision Immunotherapy Strategy for Veterinary Cancer Patients” and explains how autologous cancer vaccines may offer a more personalized way to fight cancer in dogs. This episode covers tumor antigens, neoant...

In this episode of Sit. Stay. Learn. , we discuss a 2025 Frontiers in Pain Research perspective on outcome assessment in veterinary pain studies. The episode explores why pain measurement remains such a challenge in veterinary medicine, the role of owner assessments, gait analysis, activity monitoring, and biomarkers, and why better outcome measures are essential for advancing research and improvi...

In this episode of Sit. Stay. Learn , Dr. Adrienne Wright breaks down a recent JAVMA paper examining how centrifugation force and spin time change the final composition of canine PRP . We cover what the protocols did to platelet yield , leukocyte/RBC carryover , and key growth factors like PDGF and TGF-β1 —plus the biggest takeaway: optimization data from one device doesn’t automatically translate...

This episode reviews a 2023 Biomedicines editorial by Gupta, Maffulli, and Jain on why red blood cells should be minimized in platelet-rich plasma. The discussion explores what hemolysis is, how it occurs, and what current research suggests about the presence of RBCs in PRP preparations used for musculoskeletal applications. Key points include how RBC breakdown products may contribute to inflammat...

This week, we’re exploring a fascinating human pilot study with powerful takeaways for veterinary medicine. The research, “Adipose tissue-derived mesenchymal stromal cells for treating chronic kidney disease: A pilot study assessing safety and clinical feasibility” (Villanueva et al., 2019), examined how stem cells may support kidney function in people with chronic kidney disease (CKD). Results sh...

This week on Sit. Stay. Learn. , I reviewed a 2022 study by He et al. in Frontiers in Veterinary Science that tested whether umbilical cord-derived mesenchymal stem cells (UC-MSCs) could improve recovery after trochlear groove reconstruction (TGR) in dogs. Ten healthy poodles were divided into treatment and control groups, with UC-MSCs injected intra-articularly on days 0, 7, and 14. The treated d...

Today’s Paper: Adipose-Derived MSCs for Chronic Kidney Disease This week, I’m switching gears. Most of the studies I cover are animal-focused, but this time we’re looking at a human pilot study that gives us insights we can bring right back into veterinary medicine. Paper: “Adipose tissue-derived mesenchymal stromal cells for treating chronic kidney disease: A pilot study assessing safety and clin...

This week, I reviewed a case study sent to me by our own technical services veterinarian, Dr. Larry Snyder . If you’ve never had the chance to talk with Dr. Snyder, you should—he’s got over 20 years of regenerative medicine experience and a passion for helping vets think through tough cases. The paper itself looked at platelet-rich plasma (PRP) for the treatment of prostatic cysts in dogs . It com...

For today's episode, I wanted to focus on Cats, who are often overlooked in veterinary research. MSCs offer a new approach to feline asthma. They’re immunomodulatory, capable of balancing immune responses and promoting regulatory pathways that could help manage chronic airway inflammation.

For our first episode, I wanted to look at platelet-rich plasma (PRP) . Two veterinarians recently emailed me asking whether PRP has antimicrobial properties. Honestly, I’d never really considered it before—but if it does, that would be another big advantage on top of its known uses for joint injections. It might also explain why we rarely see complications after intra-articular PRP use.