Signal and Symptoms Podcast

For a generation, your medical record has lived behind the hospital’s firewall. What happens the day the patient walks in holding it — already read, already interpreted by AI, on their own phone? In this episode, Dr. Harvey Castro hosts — with co-hosts Ed Marx and Dr. Isha Mannering — a conversation with Stephen Rouse, co-founder and head of growth at Savva, a consumer health app (in beta, launchi...

Somewhere in Oxford, there’s an AI that can produce a contrast-enhanced cardiac MRI without ever injecting the contrast. No needle, no gadolinium, no risk. It works — and it has for years. Walk into a community hospital in Dallas tomorrow, and you still can’t get it. In this episode, Dr. Harvey Castro hosts — with co-hosts Ed Marx and Dr. Isha Mannering — a conversation with Dr. Yeshe Kway , a med...

The hardest part of a pediatric visit now happens before the appointment even begins. In this episode, Dr. Isha Mannering — a board-certified pediatrician with 16 years in the Dallas–Fort Worth area and founder of InTuneMD — joins Dr. Junaid Kalia, Dr. Harvey Castro, and Ed Marx to confront a new reality in the exam room: parents arrive having already consulted TikTok and ChatGPT, and the physicia...

The foundation of tomorrow's diagnostics is being rebuilt — and it starts in biology, not silicon. In this episode, Edmund White, biomedical innovator and bestselling author, joins the conversation to challenge an assumption quietly embedded in every AI tool entering healthcare: that silicon is the only material worth building on. Drawing from three decades at the intersection of cardiac care and...

We built a healthcare system engineered for sick care, but the future of medicine belongs to those who seek health. In this episode, global Digital Health Futurist Philippe Gerwill joins the panel to unpack the real bottlenecks stalling clinical innovation. He highlights a critical inversion happening in modern medicine. Historically, technology lagged behind clinical needs. Today, advanced techno...

What does it actually cost when a diagnosis comes six months too late, a test gets ordered twice, or a treatment decision gets made without the best information available? In this special recap episode of Signal & Symptoms, we synthesize the strongest healthcare AI insights from previous episodes — moving from the promise of what AI can do, to the real patient stories that reveal what's at sta...

Will AI eliminate primary care — or finally give primary care physicians their time back? That's the central question driving this episode, as Dr. Junaid Kalia, Dr. Harvey Castro, and Ed Marx sit down with Dr. John Dayton — an ER physician who has evaluated healthcare startups as an angel investor, built pilots at Intermountain Ventures, and is now raising a $5M fund. He brings a rare view of what...

You already know not every AI tool belongs in your workflow. The real question is whether your filter is sharp enough to tell the difference. In this episode, Dr. Junaid Kalia and Dr. Harvey Castro sit down with Dr. Hansa Bhargava, Chief Innovation Officer at Healio and a physician who has spent her career building trust at scale, to examine what trustworthy clinical AI actually looks like from th...

What if the most powerful diagnostic tool wasn't a scan or a lab result — but a continuously learning model of your patient, built from their own data? In this episode, Dr. Junaid Kalia sits down with co-host Dr. Harvey Castro, this time in the guest seat, to unpack one of the most transformative concepts in modern medicine: the healthcare digital twin. They trace how the concept evolved from NASA...

Most healthcare conversations stop at disruption, but this one starts there. In this episode, three healthcare experts sit down to map what happens when AI doesn't just change clinical workflows — it rewires the economics behind them. From the slow-adoption trap crippling hospital governance, to the cultural lag quietly signaling a broken system, to a collapse of the referral pipeline impacting fi...

You went into medicine to save lives. But somewhere between residency and the real world, you started wondering — is there more I could be doing? That question is not a distraction. It might be your next diagnosis, and the biggest obstacle is knowing where to start. In this episode, host Dr. Junaid Kalia sits down with Dr. Sara Rana, a physician-turned-venture capitalist and MD-MBA, who saw the ga...

What if the difference between a late diagnosis and a successful intervention was simply how we decode the signals of a sound wave? In this episode, we are discussing the transition of ultrasound from a static hospital tool to a mobile network of care that brings diagnostics directly to the patient. Dr. Junaid Kalia, Dr. Harvey Castro, and Edward Marx explore a radical shift in medical imaging wit...

What if the real barrier to better patient outcomes isn't the medicine — it's the infrastructure to prescribe it well? This episode surfaces a broader signal: personalized medicine is no longer a future ambition — it's a present clinical need. And the system, as it stands, is not equipped to deliver it at scale. Joining the conversation are Itay Segal and Dr. Jean-Claude, co-founders of Unlock Hea...

The overarching signal is: we're early, it's messy, and the people closest to the work know it best. In this episode, Dr. Andrew Kim joins hosts Dr. Junaid Kalia, Dr. Harvey Castro, and Edward Marx for an unfiltered look at what healthcare AI implementation looks like from the inside. They are diagnosing the vendor translation failures, the physician workflow wars, the governance structures being...

When 71% of training data for FDA-approved AI comes from just three states, geographic bias shifts from a technical oversight to a direct clinical liability. To deliver on the promise of value-based care, we must move beyond "clean" academic datasets and integrate the diverse, real-world data that reflects the actual patients we serve. In this episode, Dr. Junaid Kalia and Dr. Harvey Castro sit do...

What happens when the data behind AI doesn't actually reflect the patients it's meant to help? And if precision medicine is the goal, what’s truly standing between us and getting there? These are not rhetorical questions. They sit at the center of this week's conversation with Dr. Saira Haque, Senior Director of Clinical Informatics at Pfizer Medical Affairs. Together with the hosts, they examine...

Global anxiety about AI and jobs is at its peak. And the data suggests people are right to feel it. But this episode isn't a warning. It's a diagnosis. Dr. Junaid Kalia, Edward Marx, and Dr. Harvey Castro step back from the weekly AI noise to examine the macro trajectory of the era we're actually living through — where five major innovation platforms are converging simultaneously, the cost of inte...

What happens when a 200-year-old safety-net hospital decides it's had enough of losing revenue to insurance denials and uses AI to fight back? The answer may change how you think about the intersection of clinical care and financial sustainability. In this episode, we sit down with Jani Rad, Dr. Kito Lord, and Robin Clanton from Regional One Health in Memphis, Tennessee. Together, they walk us thr...

Why do brilliant healthcare products fail before they ever reach patients? Sally Ann Frank, who leads Microsoft's worldwide strategy for health startups, exposes the fatal mistake and her proven protocol to avoid it. In this episode, Sally Ann Frank, Global Lead for Health & Life Sciences at Microsoft for startups, breaks down her proven Startup Protocol framework to achieve healthcare AI star...

Healthcare is at a critical crossroads where clinicians are increasingly sidelined by administrative weight and third-party interests. The path forward isn't just surviving a broken system—it’s reclaiming our roles as primary stakeholders and system architects through a unified, "Doctor-to-Doctor" movement. Joining us to lead this conversation is Dr. Kianor Shah, a Southern California-based oral s...

The FDA stepped back. Now, organizational governance is the only thing standing between innovation and liability. At CES 2026, the FDA officially announced it won't regulate wellness devices or Clinical Decision Support tools—removing approval bottlenecks and accelerating innovation. But this regulatory shift transfers responsibility to healthcare organizations themselves. Who builds the framework...

AI transformation in healthcare isn't something happening to physicians—it's an evolution physicians can actively shape and lead. In this episode, we introduce our host, Dr. Junaid Kalia, a practicing neurologist who experienced healthcare's systemic failures firsthand and decided to build the solution himself. As founder of SaveLife. AI, his journey embodies physician-led innovation: combining cl...

Drug development today forces patients to fit standard medications—but what if we could reverse that paradigm and design treatments tailored to each patient's unique biology? This episode explores how specialized AI cloud infrastructure is transforming drug discovery and healthcare research–not as a distant future possibility, but as tools available to researchers today. Joining the conversation i...

The most dangerous assumption in healthcare AI today is that we have time to "wait and see" how tools develop. With the state-of-the-art for AI models now shifting every 7 days, the traditional 3-year implementation cycle isn't just slow—it’s stagnating clinical transformation. In this episode, Dr. Khan Siddiqui (Radiologist and Founder of Hoppr AI) joins the panel to reveal why the future of medi...

This Holiday Special brings together 15 healthcare leaders, technologists, and innovators to tackle the biggest questions facing medicine in 2026. AI tools are proliferating across hospitals, but can healthcare systems integrate them effectively? Healthcare stands at a crossroads in 2026. AI is everywhere—from radiology to clinical decision support—but critical questions remain. Will it lower cost...