RNA Magic

Simon Daniel et al., published this research article in Trends in Biotechnology Journal and explore the application of Quality by Design (QbD) principles to RNA platform production processes. It highlights the critical quality attributes (CQAs) of RNA-based products, focusing on immunogenicity and instability, and explores the complex relationship between product quality and process parameters. Th...

ManchikatLa Rajam wrote this scientific article in the Journal of BioSciences and examines RNA silencing technology and its potential uses in crop improvement . The article highlights the advantages of RNA interference (RNAi) for developing pest-resistant crops , improving crop quality , and reducing crop losses due to various stresses . The article also discusses the concerns surrounding off-targ...

Rebeca T. Stiepel et al., wrote this article in Bioengineering and Translational Medecine and provides a historical overview of micro- and nanotechnology platforms used in medicine, dating back to the 1790s. The authors classify different technologies based on the materials they use, including inorganic, polymer-based, lipid-based, and cell-based therapies. They then discuss the successes of these...

Shuai Ding et al., published a scientific review article in the International Journal of Molecular Science that explores the applications of the CRISPR/Cas9 gene editing system in cancer therapy. The review focuses on three primary applications: CRISPR-based CAR-T cell therapy, CRISPR screening techniques for identifying new drug targets and cancer-related genes, and the use of CRISPR for generati...

This research article, published in ACS Central Science in 2021 by Kellie D. Nance and Jordan L. Meier, explores the role of N1-methylpseudouridine (m1Ψ), a modified nucleobase, in the development and effectiveness of COVID-19 mRNA vaccines . The authors highlight the importance of m1Ψ in reducing the immunogenicity of mRNA vaccines, thereby minimizing harmful side effects . They also discuss the...

This research paper from Anamul Haque published in the International Journal of Pharmaceutics reviews the development and use of lipid nanoparticles (LNPs) as delivery carriers for RNA-based therapeutics. The paper discusses the advantages and disadvantages of LNPs, including their ability to protect RNA from degradation, their strong transfection efficiency, and their low toxicity. The authors al...

This review article from Mohammad Chehelgerdi and Matin Chehelgerdi, in Molecular Cancer, focuses on the use of RNA-based treatments in the field of cancer immunotherapy . It begins by explaining the mechanisms of action and potential applications of mRNA vaccines , including their advantages over traditional vaccine techniques. The review examines the current state of mRNA vaccine technology and...

This academic review article from Wenshuo Zhou et al., discusses the advancements and applications of RNA vaccines for treating and preventing infectious diseases. It focuses on the three major types of RNA vaccines: conventional mRNA vaccines , circular RNA vaccines , and self-amplifying RNA (saRNA) vaccines . The article explores the history, development, advantages, and challenges of each type...

This review article from Attila Becskei published in the Computational and Structural Biotechnology Journal examines the impact of temperature on RNA metabolism, covering a broad range of topics from the fundamental principles of RNA folding and degradation to the practical applications of temperature control in biotechnology and forensic science. The authors discuss how temperature affects RNA st...

This article, from Vrinda Gote et al., published in the International Journal of Molecular Sciences , provides a comprehensive overview of mRNA vaccines. It covers the structure of mRNA, the role of modified nucleotides, and the mechanisms by which mRNA vaccines stimulate both the innate and adaptive immune systems. The article goes on to examine the use of lipid nanoparticles for mRNA delivery, i...

The article by He Zhang et al., titled "Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity," discusses the development of a new computational algorithm called LinearDesign . This algorithm is designed to optimize mRNA sequences to improve their stability and immune response when used in vaccines, particularly for COVID-19 and other viral diseases. The authors explain that mR...