Retina Synthesis

Retina Synthesis

Retina Synthesis is a data-focused resource exploring therapies in development for retinal diseases.

Be sure to visit the podcast's website and support the creator: retinasynthesis.com

Author

Retina Synthesis

Category

Education

Podcast website

retinasynthesis.com

Latest episode

Oct 30, 2026

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Episodes

Subretinal Gene Therapy for Neovascular AMD 03.10.2025

We review the latest results from the Regenexbio sub retinal gene therapy program with Robert Avery MD, California Retina Consultants, Santa Barbara, CA

Does Pegcetacoplan Treatment Affect Dry Macular Degeneration? 25.09.2025

We discuss whether pegcetacoplan therapy of geography atrophy affects the progression of dry AMD with Paul Hahn MD PhD of PH Retina, Nanuet, New York.

Rapid Fluid Resolution with Aflibercept 8mg may be Associated with Extended Dosing Intervals in nAMD 08.09.2025

We discuss the observation that resolution of retinal fluid at one month in eyes with nAMD treated with aflibercept 8mg may herald longer duration treatment intervals at week 96 with Michael Stewart,, MD, Knights Templar Professor of Ophthalmology, Mayo Clinic, Jacksonville, Florida.

The Good Days Dilemma - Support for Patient Co-Payments in Retinal Pharmacotherapy 28.08.2025

We discuss the current state of the Good Days charitable foundation with Dr. Michael Lai, MD. PhD, Retina Group of Washington, Assistant Clinical Professor, Georgetown University School of Medicine

Immediate vs Delayed Treatment of GA with Pegcetacoplan 19.08.2025

We discuss the long term results of the Oaks, Derby, and GALE studies looking at the benefit of early treatment of geographic atrophy in AMD with Dr. Roger Goldberg of Walnut Creek, California.

Eyes with both Geographic Atrophy and Neovascular AMD: An IRIS Study 12.07.2024

We discuss management of eyes with both geographic atrophy and neovascular AMD with Dr. Ted Leng of the Byers Eye Institute, Stanford University School of Medicine

The Davio 2 Trial for Neovascular AMD 31.05.2024

We review the 6 month results of the Davio 2 trial of  the Durayvu TKI delivery system for maintenance therapy of neovascular AMD with Dr. Carl Regillo of Wills Eye Hospital.

The GALE Extension Study 17.05.2024

We discuss the latest promising results from the GALE extension study of pegcetacoplan with Dr. Ashkan Abbey of Texas Retina Associates

AXPAXLI for Diabetic Retinopathy 09.05.2024

We discuss the promising phase I results of the Helios trial studying AXPAXLI  TKI inhibitor implant for diabetic retinopathy with Dr. Dilsher Dhoot of California Retina Consultants.

NSAIDS in the treatment of Central Serous Chorioretinopathy 18.04.2024

We discuss the use of non steroidal inflammatory agents in the management of central serous chorioretinopathy  with Dr. Michael Singer of San Antonio, Texas

EY-103 a novel Wnt Pathway Agonist for Treatment of DME and neovascular AMD 04.04.2024

We discuss remarkable preliminary results from the the use of intravitreal EYE-103, a novel Wnt pathway agonist in the treatment of DME and neovascular AMD with Dr. Charles Wykoff of Houston Texas.

Intravitreal Gene Therapy for neovascular AMD with 4D-150 28.03.2024

We discuss the first interim results of a novel intravitreal gene therapy agent, 4D-150, with Dr. Arshad Khanani of Sierra Eye Associates and the University of Nevada Reno School of Medicine.

KSI 501 Bispecific Anti-VEGF Biopolymer Treatment of DME 21.03.2024

We discuss the use of a novel bispecific anti-VEGF Anti IL-6 Antibody Biopolymar Conjugate for the treatment of DME with Dr. Mark R. Barakat of Phoenix, AZ.

Retinal Vasculitis Following Pegcetcoplan Therapy of Geographic Atrophy 14.03.2024

We discuss the occurrence of retinal vasculitis following pegcetcoplan therapy of geographic atrophy with Dr. Andrew Witkin of the New England Eye Center, Tufts University School of Medicine

High Dose Aflibercept in Severe Diabetic Macular Edema 07.03.2024

We discuss the treatment results of high dose aflibercept in the eyes in the most severe quartile of diabetic macular edema with Dr. Roger Goldberg of Walnut Creek, California.

IL-6 Inhibition in the Treatment of Uveitis Macular Edema 29.02.2024

We discuss the use of an IL-6 inhibitor in the treatment of uveitis macular edema with Dr. Sumit Sharma of the Cole Eye Institute, Cleveland Clinic.

The High Dose Aflibercept DME Trial 22.02.2024

We discuss the baseline characteristics of eyes in the HD Aflibercept Phase III clinical trial and examine their ability for extended dosing with Dr. Eric Schneider of Tennessee Retina, Nashville, TN.

The Annexon Geographic Atrophy Trial 15.02.2024

We discuss the unique results of the Annexon geographic atrophy Phase I clinical trial with Dr. Roger Goldberg of Bay Area Retina Associates, Walnut Creek, California

Diagnostics for Retinoblastoma 08.02.2024

We review the latest diagnostic and therapeutic approaches for retinoblastoma with Dr. Jesse Berry, Associate Professor of Ophthalmology, Children's Hospital Los Angeles.

A Feasbility Evaluating the Use of Home OCT for a Clinical Trial of Faricimab Treatment of nAMD 01.02.2024

We discuss the feasibility of using home OCT vs. a treat and extend approach in a clinical trial of faricimab in neovascular AMD with Dr. Kevin Blinder of the Retina Institute in Saint Louis, Mo and Profesor of Ophthalmology at Washington University School of Medicine.

Visual Outcomes in the Davio Trial Looking at TKI EY-1901 25.01.2024

We discuss the characteristics of eyes with the best visual outcomes in the Davio trial of TKI EY-1901 with Dr. Philip Storey of the Austin Retina Associates, Austin, Texas.

A Post-Hoc Comparison of Syfovre and Izervay in Treatment of Geographic Atrophy 18.01.2024

We discuss a post-hoc study comparing the efficacy of Syfovre (pegcetacoplan) and Izervay (avacincaptad pegol) with Paul Hahn, MD, PhD, of NJ Retina.

4 Year Results from DRCR Network Protocol W 11.01.2024

We discuss a comparative trial of preventive therapy for non-proliferative retinopathy vs. ad hoc treatment of disease complications with Dr. Hani Salehi-Had of Retina Associates of Southern California, Huntington Beach, California.

Gene Therapy for X-Linked Retinitis Pigmentosa 04.01.2024

We discuss the latest information on phase 2 trials of gene therapy for x-linked retinitis pigmentosa with Dr. Nadia Waheed, Chief Medical Officer of Beacon Therapeutics and Associate Professor of Ophthalmology at the New England Eye Center, Tufts University School of Medicine.

Optogenetic Therapy of Inherited Retinal Degenerations 21.12.2023

We discuss the use of optogenetics for the treatment of inherited retinal degenerations with Dr. Jose Sahel, Chairman and Distinguished Professor of Ophthalmology at the University of Pittsburgh School of Medicine.

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