Reflections on Parkinson's Disease

Professors Bas Bloem and Werner Poewe discuss the impact of OFF periods in Parkinson’s disease, exploring how they affect patients’ daily lives and the importance of optimising treatment to reduce their burden.

Professors Bas Bloem and Werner Poewe discuss the often-overlooked non-motor symptoms of Parkinson’s disease, exploring their impact on patients’ lives and the importance of recognising and managing them effectively.

Professors Bas Bloem and Werner Poewe discuss the evolving landscape of Parkinson’s disease treatment, highlighting the paradigm shift towards earlier intervention, personalised therapy, and holistic patient care.

Professors Bas Bloem and Werner Poewe discuss the practical management of re-emergent symptoms in Parkinson’s disease, offering expert insights and guidance on how to recognise, assess, and address these challenges in daily clinical practice.

Professors Bas Bloem and Werner Poewe explore the underlying mechanisms of Parkinson’s disease and discuss current and emerging therapeutic approaches. A clear and insightful conversation for anyone seeking to better understand the science behind PD and its treatment.

Join us for an exclusive live-recorded episode of 'Navigating the PD Universe' podcast, kicking off our new series at the BIAL PD Summit in Lisbon, 2025. Professors Werner Poewe and Bas Bloem welcome a remarkable special guest, Sir Nicholas Mostyn, host of the acclaimed Movers and Shakers podcast. Together, they dive into the challenges and realities of Parkinson’s disease, blending expe...

Following on from the previous episode, our hosts delve deeper into the letter N, focusing on Non Motor Symptoms with a special emphasis on Apomorphine.

Our hosts discuss the Letter N in this episode, focusing predominantly on Non Motor Symptoms. This is a two part episode for the letter N and we are delighted to share this on World Movement Disorders Day 2022.

The letter O is the focus of our Professors' attention in this episode. They discuss the concept of ON/OFF, On Demand Therapies, and the importance of Opicapone.

In this episode, Professor Werner Poewe and Bas Bloem discuss the letter G, with a particular focus on GBA and Genetics.

In Season 2, Episode 3, our Professors investigate the letter F, focusing on Fluctuations and Fatigue.

In this latest episode of the S2: ABC of Parkinson's Disease, both Prof. look into the letter E where they discuss Early Morning Off, Evidence, Exercise, Early PD.

In this new season, Prof. Poewe and Prof. Bloem will be discussing the ABC of Parkinson’s Disease - each episode will have a certain letter attributed to the many different avenues within PD.  The letter for this episode is C: COMT Inhibitors, Continuous Dopaminergic Delivery.

In this episode of Reflections On Parkinson's Disease, both professors dive into the history of Apomorphine, the role of the drug within each of their hospitals/for their patients and how the drug impacts non-motor symptoms. 

In episode 6, both Prof’s address the different experiences that they have encountered with their patients during their many years as PD specialists.  They discuss ways in which Dr’s communicate with patients on how medication problems may lead to fluctuating responses, what mechanisms can lead to changes in symptom severity and what their take is on the value of aids for communication i.e., weari...

In this latest Episode of Reflections on Parkinson’s Disease, Prof’s Bloem and Poewe discuss what is meant by ‘on/off’ fluctuations and what it entails.  They evaluate the ‘good on and the bad on’ and consider that when a patient is turned ‘on’, medication can sometimes overshoot its target, which means patients develop involuntary movements which are called Dyskinesia’s.  The Prof’s then explore...

In the anticipation of Euro 2020, both Professor’s share their thoughts on who they will be supporting at this years tournament, before delving into the topic of Response Fluctuations in Parkinson’s Disease and why they can be missed.  They discuss how a patients education on the disease is vital to explain what response fluctuations are, the current ways in which patients are recording their expe...

In Episode 3, Profs. Poewe and Bloem discuss why Parkinsons Disease patients develop fluctuations, how they can be treated & what mechanisms effect this. They also explore the practical elements of combining treatments and whether there are wiser ways of starting treatment.

In this episode, Bas and Werner delve into the term ‘motor fluctuations’ which is linked to the long-term experience patients have with Levodopa. They discuss a study by George Cotzias regarding the ‘intermittency in the action of the drug’, what the term ‘wearing off’ stands for and the differences between a short-duration/long-duration response. 

In this episode both Professors dispel the myths and misconceptions of a drug that's been used for over 50 years. They discuss the idea of a "honeymoon period" for those using Levodopa and Prof. Bloem also reveals some interesting results from a study he carried out as well as addressing how Levodopa responds to tremors. Special thanks to BIAL for sponsoring this podcast. BIAL is an...

Welcome to the Reflections on Parkinson’s podcast, brought to you by Oruen.  In this cutting edge podcast we talk around the exciting topics in Parkinson’s disease with 2 of the leading experts...Prof Bas Bloem and Prof Werner Poewe. 

Welcome to the Reflections on Parkinson’s podcast, brought to you by Oruen.  In this cutting edge podcast we talk around the exciting topics in Parkinson’s disease with 2 of the leading experts...Prof Bas Bloem and Prof Werner Poewe.