Proteomics in Proximity

Welcome to the Olink® Proteomics in Proximity podcast!    Below are some useful resources mentioned in this episode:    Reagan-Udall Foundation at FDA Gerotherapeutics in Aging Event Recording available: Affecting the Aging Trajectory:  Regulatory Constructs for Gerotherapeutic Drug, Biologic and Device Development https://reaganudall.org/news-and-events/events/affecting-aging-trajectory-regulator...

Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date. https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies Research articles and news...

Welcome to the Olink® Proteomics in Proximity podcast!    Below are some useful resources mentioned in this episode:    Olink tools and software ·       Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/     UK...

Welcome to the Olink® Proteomics in Proximity podcast!    Below are some useful resources mentioned in this episode:    Olink® Reveal, accessible NGS-based proteomics for every lab: https://olink.com/products/olink-reveal Olink tools and software ·       Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/ · ...

Welcome to the Olink® Proteomics in Proximity podcast!     Below are some useful resources mentioned in this episode:    Olink tools and software ·       Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/ ·       Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, meas...

Welcome to the Olink® Proteomics in Proximity podcast!  Below are some useful resources mentioned in this episode:    Olink tools and software Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/ Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ protein...

Welcome to the Olink® Proteomics in Proximity podcast!  Below are some useful resources mentioned in this episode:    UK Biobank Pharma Proteomics Project (UKB-PPP) , one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies     UKB-PPP online re...

Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and software • Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/ • Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ protein...

Welcome to the Olink® Proteomics in Proximity podcast!      Below are some useful resources from this episode:    Published study of primary focus Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C. Proteogenomic links to human metabolic diseases. Nat Metab. 2023 Mar;5(3):516-528. doi: 10.1038/s42255-023-00753-7. Epub 2023 Feb 23. Erratum in: Nat...

Welcome to the Olink® Proteomics in Proximity podcast!    Below are some useful resources from this episode:    Published study of primary focus Álvez MB, Edfors F, von Feilitzen K, Zwahlen M, Mardinoglu A, Edqvist PH, Sjöblom T, Lundin E, Rameika N, Enblad G, Lindman H, Höglund M, Hesselager G, Stålberg K, Enblad M, Simonson OE, Häggman M, Axelsson T, Åberg M, Nordlund J, Zhong W, Karlsson M, Gyl...

Welcome to Olink Proteomics in Proximity Podcast!    Below are some useful resources from this episode:    Highlighted publication: Girerd N, et al. Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circ Heart Fail. 2023 May;16(5):e009694. doi: 10.1161/CIRCHEARTFAILURE.122.0...

Welcome to Olink Proteomics in Proximity Podcast!      Below are some useful resources from this episode:      Highlighted article from the UK Biobank Pharma Proteomics Project (UKB-PPP): Styrkarsdottir U, Lund SH, Thorleifsson G, Saevarsdottir S, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K. Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Ris...

Welcome to Olink Proteomics in Proximity Podcast!    Below are some useful resources from this episode:    Highlighted pre-print article: Malarstig A, Grassman F, Dahl L, et al. Evaluation of Circulating Plasma Proteins in Breast Cancer: A Mendelian Randomization Analysis. ResearchSquare 2023.04.04. DOI: https://doi.org/10.21203/rs.3.rs-2749047/v1   Highlighted platform that was used to measure pr...

Welcome to Olink Proteomics in Proximity Podcast!  Below are some useful resources from this episode:  Highlighted publication: Grasberger H, Magis AT, Sheng E, Conomos MP, Zhang M, Garzotto LS, Hou G, Bishu S, Nagao-Kitamoto H, El-Zaatari M, Kitamoto S, Kamada N, Stidham RW, Akiba Y, Kaunitz J, Haberman Y, Kugathasan S, Denson LA, Omenn GS, Kao JY. DUOX2 variants associate with preclinical distur...

Welcome to Olink Proteomics in Proximity Podcast!  Below are some useful resources from this episode:  Highlighted publication: Diaz-Canestro C, Chen J, Liu Y, Han H, Wang Y, Honoré E, Lee CH, Lam KSL, Tse MA, Xu A. A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes. Cell Rep Med. 2023 Feb 21;4(2):10094...

Highlighted publication: Zannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. Eur Heart J. (2022) 43(48):4991-5002. doi: 10.1093/eurheartj/ehac495 . PMID: 36017745; PMCID: PMC9769969 . Review paper of resear...

All about Olink Flex: https://olink.com/flex Olink Insight (where you can build a 21-plex Olink Flex panel from 200 proteins): https://insight.olink.com   Sweden’s Science for Life laboratory website: https://www.scilifelab.se/about-us/ In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA)...

Primary reference:  Loriot Y and Italiano A et al. Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance. Ann Oncol. (2021) 32(11):1381-1390. doi:10.1016/j.annonc.2021.08.1748 Olink Insight Knowledge Platform with Hilda Andersson, Episode 6, Proteomics in Proximity .  Description of the MATCH-R clinical trial, “A Pros...

Primary reference:  Ticau S and Nioi P et al. (2021) Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis. Neurology. 96(3):e412-e422. doi:10.1212/WNL.0000000000011090 Information about the APOLLO clinical trial: “APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis” Link to NCT019603...

The 2019 Cell Reports paper, “Chromatin Remodeling in Response to BRCA2-Crisis” by J Gruber and M Snyder et al. is available online here . Dr. Michael Snyder’s Stanford laboratory home page is here . A 1998 Oncogene paper, “The BRCA2 is a histone acetyltransferase” by S Habibur and E S P Reddy et al. is located online here . A 2014 Cancer Discovery paper, “R-loop Processing by BRCA2 is Required fo...

Primary reference: Suhre K, Sarwath H, Engelke R, Sohail MU, Cho SJ, Whalen W, Alvarez-Mulett S, Krumsiek J, Choi AMK, Schmidt F. Identification of Robust Protein Associations With COVID-19 Disease Based on Five Clinical Studies. Front Immunol. 2022 12:781100. doi:10.3389/fimmu.2021.781100 Dr. Karsten Suhre’s Weill Cornell Medicine laboratory page: https://vivo.weill.cornell.edu/display/cwid-kas20...

To access Olink Insight free of charge, visit https://insight.olink.com   The first two data stories, with Normal Range data and COVID-19 data, has been recently updated with the first Disease Atlas, with data characterizing 15 cancer types. This is available on Olink Insight here: https://insight.olink.com/data-stories/disease-atlas-cancer To access the COVID-19 Data Story dataset itself, informa...

List of names and affiliations mentioned in the UK Biobank context: Mark McCarthy (Genentech), Slavé Petrovski (AstraZeneca), Chris Whelan (Johnson and Johnson), Erin Smith (Takeda Pharmaceuticals), Melissa Miller (Pfizer), Ben Sun (Biogen). The ASHG announcement , honoring Sir Peter Donnelly, CEO of Genomics plc and Emeritus Professor of Statistical Science at the University of Oxford with the Wi...

One of the first publications using Olink technology came out by Enroth S and Gyllensten U et al. Nature Communications 2014 “Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs”. Link to the paper is here: DOI:10.1038/ncomms5684 To access the Olink Insight platform for protein biomarker data discovery free-of-charge with an email address, click h...

The 2022 Science Advances paper, “Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods” by Daniel H Katz and Rob Gerszten et al. is available online here . A highly informative Twitter thread by the first author Dr. Daniel Katz reviewing the figures of the paper is available here . If you are interested in learning more...