Andy Wood, Matt Kirshen, Jesse Case

Probably Science

Comedy EN ↓ 623 episodes

Professional comedians with so-so STEM pedigrees take you through this week in science. Incompetently. Featuring hosts Matt Kirshen, Andy Wood (and sometimes Jesse Case or Brooks Wheelan) along with a rotating cast of special guests from the worlds of comedy and science.

Author

Andy Wood, Matt Kirshen, Jesse Case

Category

Comedy

Podcast website

probablyscience.com

Latest episode

Jul 6, 2026

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Episodes

Episode 486 - Sarah Lane 17.03.2023

Host of Daily Tech News Show Sarah Lane ( @sarahlane ) joins Jesse, Matt and Andy to talk about ballerina doppelgangers, Tom Cruise stunts, Cocaine Bear, accidentally ending up on the air , bumblebees learning to solve puzzles by watching their friends , talkin' transoms , more medical tourism , Meta's VR play and DuckDuckGo's new AI-assisted search.

Episode 485 - AI Talk with Kevin Roose 08.03.2023

New York Times technology columnist and host of the Hard Fork podcast  Kevin Roose ( @kevinroose ) joins Andy, Jesse and Matt to talk about his infamous, amorous encounter with Bing Chat/Sydney , Sydney's response to his story , getting backhanded compliments from John Oliver , how ChatGPT was dismissed by its own creators,  generative AI and the future of deepfakes , AI's capability overhang, exp...

Episode 484 - Amanda Brooke Perrin 24.02.2023

Comedian and writer Amanda Brooke Perrin ( @brookeperrin ) joins Matt, Andy and Jesse to discuss haboobs, a Tony update, a 2200-year-old flush toilet found in China , DIY Poo-Pourri, how soft food gave us the F-word , Andy's consonant invention, ChatGPT developing a theory of mind , and dolphin handjobs .

Episode 483 - Erica Spera 13.02.2023

Comedian Erica Spera ( @Spericaa ) joins Andy, Jesse and Matt to talk about almost going into dentistry, prehistoric teeth , Andy's Mexican dental tourism, what we're supposed to call mummies now , monster cereals , AI Seinfeld's heel turn , Roko's basilisk , mummy chemicals , ancient stone tools and more stone tools and Soylent .

Episode 482 - Jo Rou 04.02.2023

Comedian/filmmaker Jo Rou ( @awkwardlyjazzy ) joins Jesse, Matt and Andy to discuss Santana's answer to Beats by Dre , the mystery of a gibbon immaculate conception solved , the tiny radioactive capsule that went missing in the outback , detecting cancer with customer loyalty cards , airbrushing Boris Johnson , Jesse's bad business ideas, the Snickers dick vein , World War I talk, the awful new sh...

Episode 481 - Misophonia with Dr. Jane Gregory and Steve Hall 23.01.2023

Clinical psychologist and misophonia researcher Dr. Jane Gregory ( @drjanegregory ) and comedian Steve Hall ( @astevehall ) return to the show to talk with Matt, Jesse and Andy about Jane's work studying misophonia , what to do if your spouse's breathing drives you insane, and what's on the horizon for treating the condition. Trigger non-warning: This episode contains NO examples of misophonia-tri...

Episode 480 - Michael Magid 16.01.2023

Comedian, goalkeeper and coach Michael Magid ( @michaelmagid ) joins Andy, Matt and Jesse to discuss Michael's football (soccer) podcast Inside the 18 , his new social network The Union , quitting your gym with the help of AI, a Tesla that caused a pileup , a Tesla that thwarted a triple murder-suicide , fires in electric vs. gas cars , a breakthrough in reversing aging in mice , ripped old guys ,...

Episode 479 - Christina Martin 07.01.2023

Comedian turned author Christina Martin ( @christinamartin ) joins Jesse, Matt and Andy to talk about atmospheric rivers, shared names, Christina's book Ashes to Admin: Tales from the Caseload of a Council Funeral Officer , putting on funerals for unidentified decedents , the return of a comet after 50,000 years , Newton's madness , Heaven's Gate sneaker collection , reversing erectile dysfunction...

Episode 478 - Sean Patton 31.12.2022

Comedian Sean Patton ( @mrseanpatton ) returns to the podcast to talk with Andy, Jesse and Matt about his new special Number One , comedian affectations, paradox-free time travel , alternate Hitler histories , water pipe robots to deal with leaks and how the sun put water on the moon .

Episode 477 - Katrina Davis 22.12.2022

Comedian Katrina Davis ( @katrinasivad ) joins Jesse, Matt and Andy to discuss gene-edited hens , baby dinosaurs running on the beach , snake clitorises  and the correlation between vaccination status and car crashes .

Episode 476 - David Nihill 13.12.2022

Comedian David Nihill ( @davidnihill ) joins Jesse, Andy and Matt to discuss getting kicked out of science class, the potential impact of the release of OpenAI's mind-blowing ChatGPT , big news on the nuclear fusion front , Artemis 1 splashing down , Steve Aoki's upcoming trip to the moon , David Guetta's greatest moment  and self-medicating great bustards .

Episode 475 - Mike Bridenstine 06.12.2022

Comedian Mike Bridenstine ( @brido ) joins Matt, Jesse and Andy to talk about his podcast Hunk , a promising new HIV vaccine , the decline of key changes in popular music , the tyranny of the I V vi IV chord progression , how bin chickens learned to wash cane toads , a blast of light from a black hole , spurious correlations , how long we've known how far away the moon is , Andy's favorite dumb sh...

Episode 474 - Billy Wayne Davis 12.11.2022

Comedian Billy Wayne Davis ( @BillyWayneDavis ) joins Matt, Jesse and Andy to talk about his upcoming special TESTIFY (recorded at the International Church of Cannabis ), learning how to grow weed, the woman who only eats cheesy potatoes , seismic waves on the surface of Mars , the recent northern California fireballs , very low frequency sound that makes you dance without knowing it , bodies movi...

Episode 473 - Joel Stein 01.11.2022

Journalist-turned-podcaster Joel Stein ( @thejoelstein ) joins Andy, Jesse and Matt to talk about his excellent new show Story of the Week , Elon charging for Twitter, out-of-touch billionaires, Joel's book In Defense of Elitism , why you shouldn't pick your nose , the Madagascan primate that eats its boogers , Tribble runs, smelly time travel, writing for Time magazine , meeting falconers, the pr...

Episode 472 - Susan Rogers 26.10.2022

Record producer, audio engineer and professor Dr. Susan Rogers ' remarkable recording career included working as a staff engineer for Prince in his Purple Rain heyday, not to mention projects with David Byrne, Barenaked Ladies and Crosby, Stills & Nash. After two decades in the business, she shifted her focus to the science of music cognition, and she brings her extensive knowledge of all things a...

Episode 471 - Charles Greaves 12.10.2022

Comedian Charles Greaves ( @Greaves_Charles ) joins Matt, Jesse and Andy to discuss Jam In The Van , Nashville Armored Combat , chess boxing , spinlaunching a payload to 30,000 feet , how spinlaunching works , trying to solve the mystery of squirting , microwaving fish to make sustainable LEDs , and the dog Andy found on the road in Joshua Tree.

Episode 470 - Harrison Greenbaum 01.10.2022

Comedian/magician Harrison Greenbaum ( @harrisoncomedy ) joins Andy, Jesse and Matt to talk about doing comedy in Cirque du Soleil , the overlap between psychology, comedy and magic, men making riskier bets after a positive foretune-telling , dogs sniffing out stress in humans , successfully crashing DART into an asteroid  and the heyday of vector graphics in the arcade .

Episode 469 - Matt, Jesse and Andy 23.09.2022

Matt, Jesse and Andy are back together to talk about Matt's wedding, the chess tournament anal bead rumors , how to cheat at roulette , batteries made from crab shells , finding organic matter on Mars , making super hot stuff , breakthroughs in carbon capture , the real story behind Catch Me If You Can's Frank Abagnale and where to find quaaludes these days .

Episode 468 - Auggie Smith 06.09.2022

Auggie Smith joins Matt and Jesse to discuss his new Dry Bar special , Tasmanian Tigers , plants that love booze , finding a massive fossil in your garden and leaky rockets .

Episode 467 - Shane Mauss 20.08.2022

Comedian Shane Mauss ( @shane_mauss ) returns to the show to talk with Jesse, Matt and Andy about his upcoming Mind Under Matter science/comedy festival , Dan Ariely's study of pain , Peak-End Theory , advances in nuclear fusion  and self-pleasure in space .

Episode 466 - JC Currais 05.08.2022

Comedian JC Currais ( @jcstandup ) joins Andy, Jesse and Matt to discuss using dead spiders as robots , returning samples from Mars , a chess-bot that broke a little boy's finger and the miracle of OpenAI's D ALL-E and the more lightweight version that we used to generate way too many pictures based on text prompts .

Episode 465 - Brian Keating 22.07.2022

UC San Diego astrophysicist , podcaster and YouTuber Brian Keating ( @DrBrianKeating ) joins Matt, Jesse and Andy to talk about the inflation model versus the cyclic model of the universe, multiverses, how an astrophysicist conducts an experiment, working on BICEP at the South Pole , Brian's books Losing the Nobel Prize and Into the Impossible  and joining Brian's mailing list for your chance to w...

Episode 464 - Natalia Reagan 30.06.2022

Anthropologist/comedian Natalia Reagan ( @natalia13reagan ) joins Jesse, Matt and Andy to discuss her path from acting to the sciences, childhood fear of King Kong, primatology, a harrowing car accident, mites having sex on your face , rocket craters on the moon  and spider monkey genitalia. This episode is brought to you by Manscaped, offering Probably Science listeners 20% off and free shipping...

Episode 463 - Andrew O'Neill 23.06.2022

Comedian Andrew O'Neill ( @destructo9000 ) joins Matt, Jesse and Andy just before Andrew and Matt head off to Glastonbury to talk about Andrew's new BBC Radio 4 sitcom Damned Andrew , summoning the writing gods, working with Alan Moore, the feasibility of breathing through your butt , reverse mermaids and a fluffy crab that wears a sponge as a hat .

Episode 462 - Peter Baynham 16.06.2022

Legendary comedy writer Peter Baynham ( @peterbaynham ) of the podcast Brain Cigar joins Andy, Matt and Jesse to talk about sharks and megalodons , how bikes stay upright , another great collection of science article art and more , slinging a payload into the sky , discovering ancient Amazon settlements using lidar  and some crazy cave art . This episode is brought to you by Manscaped, offering Pr...

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