Andy Wood, Matt Kirshen, Jesse Case

Probably Science

Comedy EN ↓ 623 episodes

Professional comedians with so-so STEM pedigrees take you through this week in science. Incompetently. Featuring hosts Matt Kirshen, Andy Wood (and sometimes Jesse Case or Brooks Wheelan) along with a rotating cast of special guests from the worlds of comedy and science.

Author

Andy Wood, Matt Kirshen, Jesse Case

Category

Comedy

Podcast website

probablyscience.com

Latest episode

Jul 6, 2026

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Episodes

Episode 585 - Jeff Zenisek 14.11.2025

Comedian Jess Zenisek ( @jeffzenisek ) joins Andy, Jesse and Matt to talk about tennis, homophobic sports stereotypes, Jesse's new ski persona,  Mr. Wizard , Jeff's hair care regimen, a tiny tyrannosaur , a better rock-paper-scissors strategy , gray hair's relationship to cancer , t he worst music to play during sex  and the banger Parked By The Lake .

Episode 584 - Drew Droege 10.11.2025

Comedian/playwright Drew Droege ( @drew_droege ) joins Matt, Jesse and Andy to talk about his new off-Broadway play  Messy White Gays , X-ray NBA poker fraud  and why birds sing after a solar eclipse .

Episode 583 - Mehran Khaghani 29.10.2025

Wonderful NY comic Mehran Khagani ( @themehran ) joins Jesse and Matt to talk about escaping from Iran, working at the Harvard School of Public Health, hyrax  butt drag fossil marks, Canadian  heart transplants and the  most pristine star in the universe! In the patreon bonus we get into penguin micronaps. Click here to support Probably Science via Patreon  

Episode 582 - Jen Kober 20.10.2025

Comedian/actor Jen Kober ( @jenkober ) joins Andy, Jesse and Matt to talk about comedy in Louisiana, Oktoberfest , buxom wenches, the connection between fish buttholes and fingers , a koala chlamydia vaccine , Jesse's newfound raccoon fame , light-powered gears that fit inside a strand of hair and Jen's membership in the Star Wars canon .

Episode 581 - NASA Exoplanet Science Ambassador Anjali Tripathi 05.10.2025

NASA astrophysicist and JPL Exoplanet Science Ambassador Anjali Tripathi joins Andy, Jesse and Matt to talk about exoplanets and the different ways of finding them including radial velocity, transits and gravitational microlensing , the challenges of studying planetary atmospheres, why telescopes are built in deserts or in space, Anjali's time at the White House Office of Science and Technology Po...

Episode 580 - Michelle Murphy 27.09.2025

Comedian Michelle Murphy ( @meeshoffleash ) joins Andy, Matt and Jesse to talk about playing tennis for Grinnell, the Enhanced Games , celebrities trying their hands at winter sports , Jesse's accidental mermaid book purchase  and the Dr. Seuss book he was aiming for , Burning Man missionaries, LSD to fight anxiety  and surprisingly not too uncommon iridescent mammals .

Episode 579 - Ken Reid 17.09.2025

Comedian Ken Reid ( @kennethwreid ) joins Jesse, Matt and Andy to talk about growing up a child of television, mud wrestling,  Ken's podcast TV Guidance Counselor , an HIV prevention breakthrough , the insanity of Movie 43 , the human washing machine no one asked for , blasting plastic waste with a plasma torch , Doja Cat's nod to Max Headroom , Ladies and Gentlemen, The Fabulous Stains , the reas...

Episode 578 - Ryan O'Flanagan 09.09.2025

Comedian Ryan O'Flanagan ( @ryanoflan ) joins Matt, Jesse and Andy to talk about Ryan and Andy's chance encounter in a bar in Leadville, Married With Children tattoos , neanderthals and homo sapiens interbreeding , a novel telescope shape to help search for exoplanets , an insane impression of a neanderthal voice  and Ryan's podcast Laser Show .

Episode 577 - Myq Kaplan 29.08.2025

Comedian Myq Kaplan ( @myqkaplan ) returns to the show to talk to Andy, Jesse and Matt about growing out his eyebrows during the pandemic, babies distinguishing Ps from Bs, linguistics, sign language variations, standups aping Shane Gillis, the Mr. Beast voice, birds' preference for crapping in the air , strong link versus weak link problems , Ryan North , whether you should pay for bad art, what...

Episode 576 with Macey Isaacs! 20.08.2025

Comedian and host of the SSRI'M OK podcast Macey Isaacs joins the gang to talk about a meteorite that's older than our planet ! AI and attachment theory ! And some more AI nonsense before Andy's connection quit in a fury! In the Patreon bonus we find out why living near the ocean extends your life. Follow Macey on instagram and check out her podcast, and her Don't Tell special when it drops! Click...

Episode 575 - Matt Parker 11.08.2025

Comedian/mathematician/ YouTuber /author Matt Parker ( @standupmaths ) joins Jesse, Andy and Matt to talk about his new book Love Triangle: How Trigonometry Shapes the World , his podcast A Problem Squared , his  Edinburgh Fringe show Getting Triggy With It , Mathstodon , a hawk that uses traffic patterns to target prey , desire paths , Earth's leaking core , the Gibeon meteor , Matt's comedy tour...

Episode 574 - Josh Gondelman 01.08.2025

Comedian Josh Gondelman ( @joshgondelman ) joins Andy and Matt to talk about his new special Positive Reinforcement , his newsletter , his wife Maris Kreizman's new book of essays , the geek/nerd/dweeb/dork Venn diagram , Nancy Kerrigan and Chris Farley ,  a new ass-grass fad among chimps , ass/gas/grass bumper stickers, neanderthals eating maggots and rotten meat , how surprisingly warm Uranus is...

Episode 573 - Kai Humphries 25.07.2025

Comedian Kai Humphries ( @kaihumphries ) joins Matt, Andy and Jesse to talk about  his new special Gallivanting , the passing of Hulk Hogan, superheating solid gold , the Air Bud cinematic universe and an enormous 80,000-year-old blob in Utah .

Episode 572 - Eric Rocha 22.07.2025

Comedian Eric Rocha ( @ericrochacomedy ) joins Andy, Jesse and Matt to talk about competing namesakes, fezzes, last suppers, Jesse's macronutrient gas, sleep hygiene, comedy on airplanes, what would happen if you threw a paper airplane from the ISS , a neanderthal fat factory , Matt's standup tour and Andy's Colorado ska tour .

Episode 571 - Bryan Cook 12.07.2025

Comedian and Jimmy Kimmel Live! writer Bryan Cook ( @bryancooking ) returns to the show for a technical difficulty-laden episode in which Jesse and Andy talk with Matt while he's on a cruise ship, covering topics including comedy on a boat, candlepin bowling, a new interstellar object , crypto failures, Anthropic's Claude having an identity crisis , the Sean Connery classic Zardoz , an AI band wit...

Episode 570 - Matt, Jesse and Andy 24.06.2025

The gang's back together again to talk about how your pets alter your immune system , a plan to bomb an island full of invasive mice , why the Pentagon wants you to believe in UFOs  and a rare post-orgasm illness that causes days of flu-like symptoms .

Episode 569 - JT Habersaat 11.06.2025

Comedian and author of new book Doing Time: Comedians Talk About Standup JT Habersaat ( jtcomedy.com ) to talk about the other books on Jawbone Press ! Making bespoke action figures! Changing your brainwaves to not feel pain ! Infrared contact lenses for night vision! Other contact lenses to cheat at poker ! How joke magazine x-ray specs "work"! A shapeshifting octopus ! And whether the Loch Ness...

Episode 568 - Tom Rhodes 03.06.2025

Globetrotting headliner Tom Rhodes ( tomrhodes.net ) has a new special, The Ripest Zebras, available on his website. He joins Jesse and Matt to talk about growing up in NASA's backyard! The chair challenge ! Wasps having surprisingly good memories ! While herrings might not ! Tom's hummingbird facts! Plus how to drop an egg ! And push straws through potatoes ! In the Patreon bonus we hear about an...

Episode 567 - Ron Placone 24.05.2025

Comedian and filmmaker Ron Placone ( @ronplacone ) joins Andy, Jesse and Matt to talk about his new movie Left at Wall , the guy who let venomous snakes bite him hundreds of times for science (kind of) , a color no one had seen until now , retinitis pigmentosa  and turning lead into gold .

Episode 566 - Amy Silverberg 07.05.2025

Comedian, writer and author of upcoming novel " First Time, Long Time " Amy Silverberg ( @amysilverberg ) joins the gang to talk about Andy's Irish landscape spotting! The optimal amount of bra bounce ! Andy's Iberian adventures! Lions biting gladiators! Men fighting gorillas! And which glasses to wear to avoid the fight yourself! In the Patreon bonus we talk about lucid dreaming and a new state o...

Episode 565 - Tony Camin 02.05.2025

Great stand-up and co-creator of the Marijuana-Logues Tony Camin ( @tony.camin ) joins Jesse and Matt to talk about crows' geometry skills ! Tony helping one of the fathers of decision analysis ! Why seals don't drown ! Unlikely animal friends ! And whether your month of conception shapes your body ! Tony's new album, An Ass Pocket of Whimsy will come out on Stand-Up! Records and you can find him...

Episode 564 - Samantha Hale 26.04.2025

Comedian and Horror Nerd Samantha Hale ( @thesamanthahale ) joins Jesse and Matt to talk about: A layer of life deep below us ! The not actually back from extinction dire wolves! The Earth's mysterious pulsations ! and Reagan's obsession with the Titanic ! In the Patreon bonus we talk about bending sounds. Click here to support Probably Science via Patreon Click here to subscribe in Apple Podcasts...

Episode 563 - Live from Perth with Wil Anderson and Robyn Perkins 17.04.2025

Friend of the show  Wil   Anderson ( @officialwilanderson ) joins Matt live in Perth along with marine biologist-turned-comedian Robyn Perkins ( @robynhperkins ) to talk all things coral, nudibranchs, poisonous sea creatures and surprising things to do with dry ice and mouths.

Episode 562 - Shawn Carlow 31.03.2025

Writer/comedian Shawn Carlow ( @shawncarlow ) joins Jesse, Andy and Matt to talk about his new book People of the Titanic: 30 Tales of Extra-Doomed Souls Who Sailed on The Ship of Dreams , mouse-to-mouse resuscitation , what your poop schedule says about your health  and physicists creating a supersolid out of light .

Episode 561 - Live from Perth with Ross Noble, Kirsty Webeck and Paul Savage 18.03.2025

Live from Perth, Matt is joined by Ross Noble , Kirsty Webeck and Paul Savage to talk about if you can cook a chicken by throwing ice cubes at it , dolphins communicating with pee streams , dormant volcanoes that aren't that dormant and astronauts' eyesight .

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