Andy Wood, Matt Kirshen, Jesse Case

Probably Science

Comedy EN ↓ 623 episodes

Professional comedians with so-so STEM pedigrees take you through this week in science. Incompetently. Featuring hosts Matt Kirshen, Andy Wood (and sometimes Jesse Case or Brooks Wheelan) along with a rotating cast of special guests from the worlds of comedy and science.

Author

Andy Wood, Matt Kirshen, Jesse Case

Category

Comedy

Podcast website

probablyscience.com

Latest episode

Jul 6, 2026

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Episodes

Episode 166 - Erin Gibson 03.06.2015

Throwing Shade  co-host and Gay of Thrones  director/writer Erin Gibson  ( @gibblertron ) joins the gang to talk about Arnie at Starbucks, working at Gap, oil men and Texas textbooks, a chocolate science scam , herpes-based skin cancer therapy , Jesse's high school crack day, dementor wasps and zombie cockroaches , charismatic megafauna and the Ugly Animal Preservation Society, Erin's parallel uni...

Episode 165 - Kira Soltanovich 27.05.2015

The hilarious Kira Soltanovich  ( @kiracomedy ) returns to Probably Science to chat with the gang about naming her upcoming comedy special (and her upcoming daughter), Jesse's Smother Party and his big gay Irish following, hippie schools with cartoons and kissing teachers, a naked roommate appearance, Kira's fundraiser , Was That Science?, Corrections Corner: Wagga Wagga edition, getting attacked...

Episode 164 - Chris Crofton 19.05.2015

Comedian  Chris Crofton  ( @thecroftonshow ) of  The Chris Crofton Show  and the column  Advice King  joins the festivities to talk about doing comedy in front of your parents, Andy and Jesse's next door neighbors moving out, the worst things to buy at the grocery store, greased watermelon pool games,  the crazy creator of the Erector Set ,  getting rid of that white stuff on chocolate , more Sex...

Episode 163 - Sex at Dawn Author Dr. Chris Ryan, Caitlin Gill and Lisa Best at the Bridgetown Comedy Festival 12.05.2015

Dr. Christopher Ryan  ( @ChrisRyanPhD ), author of the New York Times bestseller Sex At Dawn , joins Matt, Andy and comedian guests Caitlin Gill  ( @robotcaitlin ) and Lisa Best  ( @lisabestcomedy ) for a live installment of Probably Science recorded at the 2015 Bridgetown Comedy Festival  ( @bridgetown ) in Portland, Oregon to talk about the prehistoric roots of modern sexuality, the devastating...

Episode 162 - Rye Silverman 28.04.2015

Comedian Rye Silverman  ( @ryesilverman ) joins Jesse, Andy and eventually Matt to discuss the legendary Marty & Elayne , trans facts, the Riddick man , how to spot a ghost, Andy's Lasik surgery, Rye as ModCloth's first transgender model ,  the origins of life on earth , fracking and earthquakes , Yellowstone magma , Bitcoin vulnerablility , a shapeshifting frog , a catfish that looks like Greedo...

Episode 161 - Ryan Singer 20.04.2015

Comedian Ryan Singer  ( @RySing ) joins the proceedings this week to talk about Eskimos, heart-to-heart hugs, the origin of toasting , when to use questions to influence people , the return of brontosaurus ,  the head transplant volunteer  and the fears about what could happen to him ,  deaf people sneezing silently ,  wiping memories  and the need for reinforcement ,  Western Razor  (use code "sc...

Episode 160 - Brendon Walsh 14.04.2015

Comedian and Bone Zone podcast  host Brendon Walsh  ( @brendonwalsh ) joins the gang to talk about Better Than Ezra, things that track, most favored nation clauses,  the ubiquity of problematic , the greatest voicemail Andy ever received, how to call in sick,  Alzheimer's and Reagan , Brendon's Mike Tyson encounter, the problem with human cannibalism, cleaning your brain surgery tools,  laser woun...

Episode 159 - Water Crisis with Jay Famiglietti 07.04.2015

Professor of earth system science at UC Irvine and senior water scientist at NASA/JPL Jay Famiglietti  ( @JayFamiglietti ) recently wrote an LA Times op-ed on the dire state of California's water supplies , catalyzing the nation and helping contribute to recent historic mandatory water restrictions from Governor Jerry Brown . Jay joins Matt, Jesse and Andy in an overly watered backyard to talk abo...

Episode 158 - Caitlin Doughty 31.03.2015

Mortician, author , blogger, YouTube personality  and death advocate Caitlin Doughty ( @TheGoodDeath ) invites Matt, Jesse and Andy into her home to talk about all things death, including her book Smoke Gets In Your Eyes , The Order of the Good Death , death rituals around the world, the history of embalming in the US, what goes down in a crematory, why dead bodies aren't dangerous to be around, o...

Episode 157 - Robin Ince and Brian Cox 25.03.2015

Comedian/actor/writer  Robin Ince  ( @robinince ) and physicist/host/musician  Brian Cox  ( @ProfBrianCox ), both of BBC Radio's  The Infinite Monkey Cage , were kind enough to sit down with Matt and Jesse while they were stateside for a recent live performance, discussing David Lynch's America, why the queen is common,  Alzheimer's being treated by ultrasound ,  Brian's pop group D:Ream , the sil...

Episode 156 - Sara Schaefer 10.03.2015

Comedian and host of Nikki & Sara Live  Sara Schaefer  ( @saraschaefer1 ) joins the proceedings this week to talk about her debut album Chrysalis , denim facts, David Attenborough, phony   pheromones , why adolescents are dumber, old nana orcas who help the pod , time travel plans and 9/11 tales, head transplants , Tiki bars, average penis size  and the labia library.

Episode 155 - Laraine Newman 09.03.2015

Original SNL cast member and founding member of The Groundlings   Laraine Newman  ( @larainenewman ) joins the show this week to tell tales of the early days of  Saturday Night Live , not to mention her myriad voice acting roles ,  smoking mimes , Tiki pioneers, teachers with wet lower lips, Dan Aykroyd's house, SNL40 , frog dissection and horror movies, spider painkillers , worms that crawl in an...

Episode 154 - Brooks Wheelan Returns 03.03.2015

Original Probably Science co-host Brooks Wheelan  ( @brookswheelan ) returns to the show after spending a year on  Saturday Night Live , not to mention appearing on Girls, Conan , and Late Night with Seth Meyers , to give the inside scoop on what it's like to join the cast of the most iconic sketch comedy series ever,  RHCP tattoos , Terry Crews and David Prowse,  handshake-smelling ,  Juggalos an...

Episode 153 - Nikki Glaser 25.02.2015

Nikki Glaser  ( @nikkiglaser ) of Nikki & Sara Live!, Conan, @midnight, I Am Comic and much more joins Matt , Andy  and Jesse  this week to talk about her love of ASMR, the threat of peak phosphorus, gerbils and rats and plagues, oh my! , Genghis Khan, NYC subway deaths, cheating fingers ,  parasitic zombie wasp beetles ,  naughty aphids ruining symbiosis for everyone ,  light slowed down , a teas...

Episode 152 - Barry Castagnola 18.02.2015

British comedian and actor Barry Castagnola  ( @BarryCastagnola ) joins Jesse, Andy and Matt to discuss Midwest cold, royal warrants and drugs, Mick Jagger, chicks and number lines , lefthanded people, musicians and music stands, mudsharks  and Who jackets, rodents of unusual size with giant teeth , high-speed lasers that can see molecules , an even larger reboot of the Large Hadron Collider , the...

Episode 151 - Jackie Gold 12.02.2015

Comedian Jackie Gold  ( @iamjackiegold ) joins the crew this week to talk about Barbie dolls, Jackie's genetics, pheromone parties, Broken Heart   Syndrome ,  over-the-counter meds linked to dementia ,  Matt's fake foreign accent ,  bad BICEP/good BICEP ,  UK lawmakers approving three-parent babies  and how exactly those are made , and the wonders of J-Date.

Episode 150 - Todd Glass 04.02.2015

Comedy legend , podcasting pioneer and author Todd Glass ( @ToddGlass ) helps Andy, Matt and Jesse celebrate the 150th episode and the new identities they’ve been assigned by discussing stalagmites and stalactites, Jesus painting restoration , anonymous donors, a guy with endless déjà vu , ketamine and anesthetics, boners and massages, bouncing water , sex education, unboiling an egg , getting pai...

Episode 149 - Patrick Keane 26.01.2015

Former psychology major and tight end-turned-comedian Patrick Keane  joins the proceedings this week to talk with Jesse, Andy and Matt about Chinese diaper trains, Wims and Pims, the video of Stefan Pop's visit to Bluebell Ranch , celebrity photographs and autographs, snow shoveling and heart attacks , polar bear wangs and pollution , some annoying truth-stretching in The Imitation Game , Alan Tur...

Episode 148 - Tone Bell 14.01.2015

Television's Tone Bell  finally makes his Probably Science debut this week to help the gang with topics including Ted Bundy's jello woes, Tone's cat restructuring, a punk rock Joe Strummer   snail ,  weird shipwreck metal ,  ancient milk drinking ,  how Facebook likes can predict personality ,  ketamine's depression uses , Andy's Uber/Lyft tales,  an unbeatable poker computer  and things Jesse wou...

Episode 147 - Gareth Reynolds 13.01.2015

Comedian and co-host of The Dollop   Gareth Reynolds joins Jesse, Andy and Matt this week to talk about Hollywood tourists, Gareth's important moss experiments, airborne farts , the point of the narwhal's point , an antibiotic breakthrough , what self-tickling tells us about brains , materiAl vs. materiEl ,  why lady jizz ain't jizz , why lady jizz may in fact be jizz , HIV getting milder  and Nat...

Episode 146 - The Gang Returns 08.01.2015

Matt, Jesse and Andy haven't seen each other in about a month, so this week's episode is a guest-free chance for everyone to catch up on each other's December goings-on, including Andy's Nicaraguan war stories and Jesse's bro-lesque competition, along with updates on SpaceX's aborted launch , Elon Musk's Reddit AMA , a British effort to send a probe to the moon  ( and how you can add your DNA to t...

Holiday Bonus Episode with Jesse and Lizard Case 01.01.2015

The ProbSci gang aren't all back in town together just yet, so to hold you over until our next new episode, please enjoy Jesse's interview with Lizard Case, a Nashville songwriter and tavern proprietor who also happens to be his father. Happy New Year!

Episode 145 - Janet Varney 23.12.2014

Actor/ podcaster /improv master/festival producer Janet Varney  ( @janetvarney ) sits down with the crew on this week's episode to talk about voicing the hero of The Legend of Korra , the hilarious Bachelor parody Burning Love , Janet's first LA acting gig on Catwoman, growing up near Biosphere 2 , Janet's award-winning science fair project on burning stuff, trash-eating seagulls , Radiolab's look...

Episode 144 - Dr. Christina Campbell 16.12.2014

Anthropologist and spider monkey expert Dr. Christina Campbell  joins the gang this week to get an update on Jesse's kidney stones and talk about her field of expertise, including research on Barro Colorado Island , the snubbing of Darwin contemporary Alfred Russel Wallace , Jesse trying to adopt a wallaby,  Chris Burke’s Eating Is Fun/Eating Is Serious , Dr. Campbell's book on spider monkeys , th...

Episode 143 - Mike Phirman 09.12.2014

Shop Amazon for the holidays  and enjoy comedian and musician Mike Phirman  ( @phirm ) as he joins the crew to talk about kidney stones and Jesse's trip to urgent care, Mike's iodine allergy, the millenial malady of text neck , a man who can sort of hear wifi , the sound of Comet 67P and Philae , Hard 'n' Phirm's ode to the numerical value pi , Chicken Monkey Duck , Build-a-Song , Trace Elements ,...

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