Pioneers of AI

It often feels like the world is divided when it comes to AI — do you lean in, or opt out?. But what if that tension exists within your own household? In this episode, Rana brings her kids onto the show for a candid conversation about AI adoption. Her son Adam is an AI enthusiast and her daughter Jana is an AI skeptic, a dynamic she wrote about in a recent essay, " I'm an AI Scientist, My Daughter...

At the 2026 FIFA World Cup, AI has already played a role in high stakes moments – revealing “just barely” violations that have broken hearts and driven hopes for millions of fans. As the tournament’s technology partner, Lenovo has augmented the game with new tools like virtual models of each player, balls equipped with motion sensors, and thousands of cameras logging every second of play. Lenovo C...

While many tech companies race to build ever-larger AI models, IBM CEO Arvind Krishna sees the future differently. Speaking with host Bob Safian before a live audience during New York Tech Week, Krishna explains why enterprises are overcomplicating AI adoption, what kinds of risks leaders should be taking right now, and how to weigh AI's costs against its benefits. He also shares why IBM believes...

Anthropic and OpenAI’s plans to go public have set off waves of speculation about the ripple effects, and how they’ll stack up to the SpaceX IPO. What’s really driving the value of these companies? Does the timing of the IPOs matter? How might they impact the AI startup ecosystem? To process all this, Rana phones a friend: Reid Hoffman. As co-founder of LinkedIn and Manas AI, a longtime Microsoft...

Natalie Monbiot is the founder of Virtual Human Economy (VHE)  and  was one of the first experts to advocate that your digital twin can be one of your most valuable assets. In fact, she argues that when we use AI models like ChatGPT and Claude, we are already creating a digital twin of ourselves. We welcome Natalie back to the show, following up on some topics we touched upon in our 2025...

Big Tech is moving fast on AI. But who's watching out for the rest of us? Aza Raskin, co-founder of the Center for Humane Technology, has spent years sounding the alarm about where the race to build powerful AI is actually taking us. He joins Rapid Response to expose the incentive structures quietly pushing Silicon Valley toward dangerous territory, and to make the case that it's not too late to c...

Historically, the only way to know what was going on in your body was to make a doctor’s appointment, run tests, and wait for the results. Now, wearable tech is changing access to health data. Rana sits down with Tom Hale, CEO of Ōura, the company behind the smart ring found on the fingers of everyone from elite athletes to patients managing chronic illness. Together they discuss how wearables giv...

When MasterClass CEO David Rogier was a kid, his grandmother sat him down and told him how she'd lost everything during World War II. The lesson David took from her is that education is the one thing no one can ever take from you. That idea became the basis of the online learning platform he co-founded, MasterClass. Now, after celebrating its 10-year milestone, AI is leading David to reimagine wha...

When Duolingo CEO Luis von Ahn sent an internal memo about AI last year, he didn't expect it to go viral — or to ignite a firestorm about the future of work. Now he joins Rapid Response to unpack what he got right, what he got wrong, and what the backlash taught him about the real limitations of AI. Von Ahn also reveals why he's made a deliberate pivot in 2026: chasing users, not revenue — and wha...

Many parents are wondering how their kids’ lives will be shaped by AI. Will it help them land a future job or make that job obsolete? Will it coach them toward more meaningful relationships or replace human connection altogether? As we enter a moment in history where AI may, for the first time, surpass human intelligence, one thing is clear: we need to make sure this technology is safe. At the MIT...

We all feel the urgency: learn to use AI, or risk falling behind at work. And we all know there's an upside: AI can reduce tedious tasks, streamline operations, and boost output. But knowing is half the battle (maybe even less) and implementing AI needs to happen across an entire organization. So what does it take to start? Well, here at WaitWhat (the company behind this podcast!) we paused all op...

This week, we're sharing something from our friends over at Possible. In this episode of Possible, Reid Hoffman and Aria Finger talk with Sean Neville, co-founder of Circle and architect of USDC, about building the financial infrastructure for an AI-driven economy. Now leading Catena Labs, Neville is working on what he calls the first AI-native bank —designed for autonomous agents that can tr...

It’s not easy to cover AI as a reporter when the technology moves so fast. Joanna Stern’s approach: learn by doing. For one year, the longtime Wall Street Journal tech reporter and Pulitzer Prize finalist embedded AI into every corner of her life: her doctor's office, her kids' toys, even her romantic relationships. (Her wife approved the last one.) Stern chronicles the experience in her new book,...

Tractors are smarter than you think. John Deere, the nearly 200-year-old company, is combining sensors, data, and machine learning in highly advanced vehicles and software to reinvent how the world grows food. On this Pioneers of AI episode, John Deere CTO Jahmy Hindman breaks down how AI is making farms faster, smarter, and more sustainable. Plus he shares his vision for a fully autonomous farm....

The rhetoric around AI tends to swing between doomerism and idealism, but the reality is much more nuanced. In this special live episode, Pioneers of AI turns the tables; MIT Sloan professor Sinan Aral interviews host Rana el Kaliouby and gets her candid perspective on the current state of AI. Dr. el Kaliouby makes the case for  human-centric artificial intelligence that augments humans, rather th...

AI is transforming one of the oldest industries on Earth: mining. KoBold Metals is a mineral exploration company using AI to locate deposits of copper, lithium, and other resources. This is more critical than ever. These raw materials power electrification, AI infrastructure, and the global clean energy transition. On this episode, KoBold co-founder and president Josh Goldman takes us on a modern-...

What does a former skydiver have to say about getting started with AI? Go ahead and jump! While Maia Josebachvili doesn’t spend her free time leaping out of airplanes these days, she still is a firm believer in taking calculated risks. It's a mindset that's followed her to her role as Chief Revenue Officer of AI at Stripe, a financial services platform at the forefront of agentic commerce. On this...

AI is moving fast. But are we really keeping humans at the center? In this special live Rapid Response, recorded on stage at South by Southwest, host Bob Safian sits down with AI scientist, founder of Affectiva, investor at Blue Tulip, and host of Pioneers of AI, Dr. Rana el Kaliouby. El Kaliouby makes the case that human-centric AI isn't just a safety guardrail; it's the key to thriving socially,...

Samaya AI is bringing AI agents to Wall Street and the biggest firms are paying attention. Their agents tackle complex analysis that financial professionals do every day. Which raises some big questions: What happens when AI can do your work? And in an industry where billions of dollars are on the line — how do you make sure these AI systems are reliable? Samaya co-founder and CEO Maithra Raghu jo...

AI is dominating news headlines, but how do we find a signal in the noise to tell us where AI is headed? Host Rana el Kaliouby brings in Fortune’s AI editor Jeremy Kahn for a candid conversation on the biggest AI storylines: the Anthropic-Pentagon standoff, waves of AI-driven layoffs, war in the Gulf states, and more. We dig beneath the surface to get into what these moments mean for the industry...

Most humanoids are built to perform tasks. Grace Brown is building one that can authentically connect. As co-founder and CEO of Andromeda, Brown is on a mission to solve the loneliness epidemic with Abi, a social robot designed for the aging population. In this episode, Rana el Kaliouby sits down with Brown to talk about why physical AI needs emotional intelligence, how nonverbal cues make or brea...

There's no shortage of headlines about AI's environmental toll — but what if this technology could also help solve the climate crisis? Priya Donti, MIT Assistant Professor and co-founder of Climate Change AI, believes AI can play a critical role in the fight against climate change, though she's quick to say it's no silver bullet. Donti is using machine learning to tackle some of our most urgent en...

This week, we're sharing something from our friends over at Possible. In this special live episode, hosts Reid Hoffman and Aria Finger sit down with Wispr Flow founder and CEO Tanay Kothari to explore a post-keyboard future where voice becomes the primary way humans interact with computers. From building one of the world’s first voice assistants as a child to creating a product now used the world...

Business headlines scream about when we’ll see a one-person “unicorn” company, thanks to AI. Journalist Evan Ratliff put this to the test in the second season of his podcast Shell Game. A former startup founder, Ratliff created a company, HurumoAI, where he is the only human. Even his two co-founders are bots. As Ratliff built his startup with AI agents, he explored deeper questions of living and...

As agentic AI continues to rise, many wonder when Apple will give Siri an AI overhaul. Siri is perhaps the most ubiquitous and well-known voice assistant, the one that got users comfortable talking to our phones. Without Siri, who knows what kind of interface tools like ChatGPT would have? On this Pioneers of AI episode, Rana el Kaliouby talks to Siri co-founder Adam Cheyer about why the platform...