NPLEX on the Go

In this episode, we work through a classic case of heavy menstrual bleeding, pelvic pressure, and infertility caused by uterine fibroids. Using four board-style questions, we connect pathology, anatomy, physiology, and reproductive complications to understand the hormonal and structural mechanisms underlying leiomyomas.  Topics covered include: • Leiomyoma pathology and smooth muscle proliferation...

In this episode, we break down a classic non-contact ACL injury in a teenage athlete presenting with knee instability, immediate swelling, and a positive anterior translation exam. Through four board-style questions, we integrate anatomy, biomechanics, physiology, and connective tissue biology to understand the mechanisms underlying this common sports injury. Topics covered include: • ACL anatomy...

In this episode, we work through a classic case of ascending weakness and areflexia following a recent gastrointestinal illness. Using four board-style questions, we connect immunology, neuroanatomy, microbiology, and pathology to understand the mechanisms underlying Guillain-Barré syndrome. Topics covered include: • Peripheral nerve demyelination and Schwann cells • Type II hypersensitivity react...

In this episode, we work through a classic case of lateral hip pain in a recreational runner with pelvic instability and hip abductor weakness. Using four board-style questions, we connect anatomy, biomechanics, pathology, and physiology to understand Trendelenburg gait and the mechanical stresses involved in hip stabilization. Topics covered include: • Superior gluteal nerve injury and Trendelenb...

In this episode, we work through a classic occupational lung disease case involving progressive dyspnea, restrictive lung disease, and long-term asbestos exposure. Using four board-style questions, we connect pathology, anatomy, physiology, and immunology to understand the hallmark findings and complications of asbestos-related lung injury. Topics covered include: • Ferruginous bodies and asbestos...

In this episode, we work through a classic infective endocarditis case involving IV drug use, fever, a new murmur, and Staphylococcus aureus bacteremia. Using four board-style questions, we connect microbiology, anatomy, pathology, and cardiovascular physiology to understand the hallmark features and complications of right-sided endocarditis. Topics covered include: • Why IV drug use classically a...

In this episode, we work through a cirrhosis case involving portal hypertension, ascites, and chronic liver disease. Using four integrated board-style questions, we review the anatomy, physiology, immunology, and pathology behind some of the most commonly tested liver concepts. Topics covered include: • Portal-systemic anastomoses and esophageal varices • RAAS activation and ascites formation • He...

In today’s episode, we break down a classic peptic ulcer disease case involving epigastric pain, melena, and a positive urease test. Through four board-style questions, we connect anatomy, physiology, microbiology, and biochemistry to understand the mechanisms behind ulcer formation and complications. Topics covered include: • Posterior duodenal ulcers and gastroduodenal artery bleeding • Parietal...

In this episode, we work through a classic inflammatory bowel disease case featuring recurrent bloody diarrhea, urgency, and continuous colonic inflammation. Using four board-style questions, we review the key distinctions between ulcerative colitis and Crohn’s disease across pathology, anatomy, physiology, and complications. Topics covered include: • Crypt abscesses and mucosal inflammation in ul...

In this episode, a young woman buys a new bracelet, and within two days she’s dealing with an intensely itchy, blistering rash that keeps her up at night. What’s going on beneath the skin? We’ll peel back the layers — literally — to explore the immune mechanisms, hypersensitivity reactions, and how to tackle board-style questions that test your knowledge of anatomy, immunology, microbiology, and p...

In this episode, we dive into a clinical case featuring  a 25-year-old AMAB patient with a painful, swollen lesion on his left thigh. Through 4 questions across  Anatomy, Physiology, Pathology, and Biochemistry,  we’ll walk through the key features, connect them to what’s happening at the tissue level, and explore the basic science behind the body’s response to this kind of infection. Show Notes a...

What do a massive postpartum hemorrhage, an ‘empty’ space in the skull, and an inability to breastfeed have in common? We’ll find out today as we follow the endocrine aftermath of a postpartum hemorrhage and uncover how a single event can lead to multi-hormone deficiency. Show Notes at www.variabilityscience.com/nplexonthegopodcast.

In this episode, we dive into a condition where the immune system turns the airways into a battleground. You’ll hear how allergens trigger smooth muscle spasms, why eosinophils leave behind crystal footprints, and what changes in lung volumes reveal during an attack. Four angles— pathology, anatomy, physiology, and immunology —coming together in one wheezy case. Show Notes at www.variabilityscienc...

This case explores a newborn presenting with  electrolyte disturbances  and  ambiguous genitalia  due to a  steroidogenic enzyme deficiency . Through a multidisciplinary lens, we dissect the pathophysiology, anatomy of adrenal zones, hormonal regulation, and relevant biochemical pathways. Show Notes at www.variabilityscience.com/nplexonthegopodcast.

In this episode, we dive into a clinical case featuring a  68-year-old AMAB patient with right leg weakness . We’ll explore questions and explanations across  Anatomy, Physiology, Pathology, and Biochemistry. Show Notes at www.variabilityscience.com/nplexonthegopodcast.

In this episode, we assess a clinical case featuring a  21-year-old nonbinary patient with dark colored urine  after recently recovering from a sore throat. We’ll explore questions and explanations across Anatomy, Physiology, Pathology, and Biochemistry. Show Notes at www.variabilityscience.com/nplexonthegopodcast.

In this episode, we dive into a classic upper extremity case involving  shoulder pain  in a physically active adult. This case explores four questions that cover the critical aspects of rotator cuff injuries. Learn how to dissect pathophysiology, muscle anatomy, fiber types, and collagen biochemistry. Show Notes at www.variabilityscience.com/nplexonthegopodcast.

In this episode, we dive into a classic presentation of a hematologic condition that often goes overlooked in menstruating women. With cravings for pagophagia , koilonychia , and fatigue , we uncover the pathophysiology and clinical pearls of this common condition. Show Notes at www.variabilityscience.com/nplexonthegopodcast.

Today’s case is a middle-aged man with persistent epigastric pain, a caffeine habit, and a love for ibuprofen—unfortunately, his stomach lining isn’t loving him back. We'll practice some questions about the pathophysiology, anatomy, physiology, and biochemistry for what’s going on beneath the surface. Show Notes at www.variabilityscience.com/nplexonthegopodcast.

In this episode, we dive into a clinical case featuring a  9-month-old baby with poor feeding, regression of previously acquired motor milestones, and increased startle response . We’ll explore questions and explanations across  Anatomy, Genetics, Pathology, and Biochemistry . Show Notes at www.variabilityscience.com/nplexonthegopodcast.

In this episode, we dive into a clinical case featuring a  59-year-old man with chest pain  while watching television. We’ll explore questions and explanations across  Anatomy, Physiology, Pathology, and Biochemistry. Show Notes at www.variabilityscience.com/nplexonthegopodcast.

Welcome to  NPLEX on the Go , a new podcast designed to help you practice high-quality NPLEX 1 style questions - anytime, anywhere. This introductory episode will go over some study strategies to help you prepare for the Naturopathic Physicians Licensing Exam, Basic Science portion and introduce you to the question bank and style of future episodes. Show Resources at www.variabilityscience.com/npl...