NIH Collaboratory

Drs. Brad Hammill and Keith Marsolo discuss the use of death as an endpoint, a section in the Living Textbook chapter on Choosing and Specifying Endpoints and Outcomes. Read the chapter: https://rethinkingclinicaltrials.org/chapters/design/choosing-specifying-end-points-outcomes/choosing-and-specifying-endpoints-and-outcomes-introduction/

Roy Perlis of Harvard Medical School and JAMA+ AI expands on key takeaways from his recent Grand Rounds presentation, “Keeping a Human in the Loop: Scientific Publishing and AI.”

Majid Afshar and Mary Ryan Baumann discuss the conduct and results of their pragmatic trial.

Drs. Jonathan Moyer and David Murray discuss their recent publication, “Evaluating Analytic Models for Individually Randomized Group Treatment Trials With Complex Clustering in Nested and Crossed Designs.”

Drs. Adrian Hernandez and Christopher Lindsell discuss their recent publication, “Ensuring Virtual Vigilance in Decentralized Clinical Trials," as well as the new Living Textbook Chapter on Decentralized Pragmatic Clinical Trials.

Dr. David Zaas discusses key takeaways from his recent keynote presentation: “Landscape of Healthcare in America: Gaps and Opportunities (That Researchers Need to Hear)."

Drs. Shruti Gohil and Jeffrey Guy discuss key takeaways from "INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients," also known as the INSPIRE trial.

Drs. Sebastian Tong and Julie Fritz expand on key takeaways from their recent Grand Rounds presentation.

Dr. Emily O'Brien shares key takeaways from her recent Grand Rounds presentation, "Avoiding the Fumble: Building on a Decade of Lessons from Pragmatic Clinical Trials."

Drs. Greg Simon and Lorella Palazzo discuss their recent Living Textbook Chapter, "End-of-Trial Decision-Making." Read the chapter: https://rethinkingclinicaltrials.org/chapters/dissemination/end-of-trial-decision-making/introduction-end-of-trial-decision-making/

Drs. Pearl O'Rourke and David Wendler discuss their recent publication, "Disentangling Informing Participants From Obtaining Their Consent."

Drs. Lesley Curtis and Keith Marsolo discuss the new learning module "Healthcare Data Interoperability and Standardization for Research."

Drs. Rich Platt, Hayden Bosworth, and Greg Simon consider how to make pragmatic trials more pragmatic.

Dr. James Tulsky and Dr. Angelo Volandes discuss "Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly," also known as the ACP PEACE trial.

Dr. Pearl O'Rourke and Dr. Stephanie Morain discuss waiver or alteration of informed consent for minimal risk clinical investigations.

Dr. Michael Pencina and Dr. Brian Anderson discuss Public-Private Partnerships in the Trustworthy Health AI Ecosystem.

Dr. Harlan M. Krumholz and the PaxLC research team discuss Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial.

Dr. Julie Fritz discusses "BeatPain Utah: Partnering with Community Health Centers Within a Socio-Technical Framework."

Dr. Joshua Denny discusses the All of Us Research Program: Improving Health Through Diverse Technology, Huge Cohorts, and Precision Medicine.

Drs. Russell Rothman and Erin Holve discuss a decade of research in PCORnet®.

Dr. Michael Gibson discusses The Heartline Trial and a new paradigm in conducting virtual clinical trials.

This podcast continues the discussion with Dr. Emily Largent as she discusses ethical considerations for vulnerable populations participating in pragmatic clinical trials.

Dr. John Concato discusses the 2021 FDA draft guidance on real-world evidence.

Dr. Christopher Lindsell discusses research outcomes and the importance of choosing the correct outcome.

This podcast continues the discussion with Diana Berrent, JD, and Nick Guthe, founder and member of Survivor Corps, and Natalie Lambert, PhD, of the Indiana University School of Medicine, as they describe best practices for medical professionals treating patients experiencing debilitating effects of COVID-19.