Neural Pharm Podcast

References: Psychedelics legislation in Colorado Springs: https://gazette.com/health/fountain-joins-colorado-springs-in-seeking-to-regulate-fledgling-psychedelic-mushroom-industry/article_22a66456-a1da-11ef-a515-57588c741084.html Oregon Psilocybin Ballot Measure Results: https://www.opb.org/article/2024/11/07/psilocybin-ban-mushroom-hallucinogenic-ballot-politics-elections-oregon/ Vermont Psychede...

Show notes and references: * Please note: This was recorded prior to the election on Nov 5. We will discuss the results and predictions for the future of healthcare policy in America in our next edition.” Kanna references: Bennett, A. C., et al. "Sceletium tortuosum may delay chronic disease progression via alkaloid-dependent antioxidant or anti-inflammatory action." Journal of physiology and bioc...

**Note this was recorded the first week of July before President Biden announced he would not run for re-election. I know that feels like a lifetime ago but just jump in your time machine for a bit at the beginning of the podcast please. We will likely start our next episode on the pharmacology of Kanna with a “catch up” on Kamala Harris v Trump** Footnotes, References and corrections: See below t...

For more information on Shuna’s work visit: https://www.shunamorelli.com/ Get full access to Neural Pharm at neuralpharm.substack.com/subscribe

**To learn more about Danielle and the services she provides, go to the Microdosing Humboldt website: https://www.microdosinghumboldt.com/home or follow her on Instagram at: https://www.instagram.com/microdosinghumboldt/ ** Get full access to Neural Pharm at neuralpharm.substack.com/subscribe

Thanks for reading Neural Pharm! Subscribe for free to receive new posts and support my work. References: Cassels B, et al. Dark classics in chemical neuroscience: mescaline. ACS Publications. 9 Sept 2018. https://pubs.acs.org/doi/10.1021/acschemneuro.8b00215 Dinis-Oliveira RJ, et al. Pharmacokinetic and pharmacodynamic aspects of peyote and mescaline: clinical and forensic repercussions. 1 Aug 20...

Thanks for reading Neural Pharm! Subscribe for free to receive new posts and support my work. Footnotes: —Yes I will acknowledge that I mispronounced “anecdotal” a few times during this interview. For some reason this is always one of those tricky words for me to say, and even past Presidents and Presidential candidates have mispronounced words from time to time. If you want to roast me for it (po...

Thanks for reading Neural Pharm! Subscribe for free to receive new posts and support my work. References: Arrone L, et al. Continued Treatment with Tirzepatide for Maintenance of Weight Reduction in Adults with Obesity: the SURMOUNT-4 Randomized Clinical Trial. JAMA . 11 Dec 2023. https://jamanetwork.com/journals/jama/fullarticle/2812936 Attia P and Gifford B. Outlive: The Science & Art of Longevi...

Ibogaine References: Alper K, et al. Ibogaine: Scientific Literature Overview. International Center for Ethnobotanical Education. 2012. Available at: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.iceers.org/Documents_ICEERS_site/Scientific_Papers/ibogaine/ICEERS2012_Ibogaine_literature_compilation.pdf Corkery JM. Ibogaine as a Treatment for Substance Misuse: Potential Benefits an...

Footnotes: For more on how to help our nation’s veterans: https://www.va.gov/REACH/ Veteran crisis line: Dial 988 and press 1. Or text 838255. Seasonal Affectiveness Disorder. National Institute of Mental Health. https://www.nimh.nih.gov/health/publications/seasonal-affective-disorder Kentucky Ibogaine Initiative: https://www.kentuckyibogaineinitiative.com/ Huberman, Andrew. Mental Health Toolkit:...

*For listeners in the Seattle/Tacoma/Bellevue area: Mention this podcast and receive 10% off an initial ketamine treatment series at NW Ketamine Clinic For more information go to: https://nwketamineclinics.com/ Get full access to Neural Pharm at neuralpharm.substack.com/subscribe

Foot notes: UK article on Psilocybin therapy cost effectiveness: McCrone P, et al. Cost effectiveness of psilocybin assisted therapy for severe depression: exploratory findings from a decision analytic model. Psychological Medicine. 2 June 2023. https://www.cambridge.org/core/journals/psychological-medicine/article/costeffectiveness-of-psilocybinassisted-therapy-for-severe-depression-exploratory-f...

Footnotes: To find out more on Psyched Wellness, or to order Calm to have it shipped to home, click on the link here : For more on Amanita Muscaria , please view the article I published on my Substack by clicking the link here Wired article on microdosing: https://www.wired.co.uk/article/microdosing-workplace-shroom-boom#intcid=_wired-uk-bottom-recirc_397cdbf7-d656-4f04-b4a2-111a2dd3ef9f_entity-to...

***Please take a couple minutes to complete a brief survey about the podcast here . If you have any specific open ended feedback for the podcast, please feel free to leave a comment below or email at cburns@neuralpharm.net*** References: “Ayahuasca and 5 Me-ODMT.” UC Berkeley Center for the Science of Psychedelics. Last accessed 28 Sept 2023. https://psychedelics.berkeley.edu/substance/ayahuasca/...

References: Article referenced in the beginning: Martinez-Marmol, et al. Hericerin derivatives activates a pan neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spacial memory. Journal of Neurochemistry . 2023(165);6: 791-808 Ballard E and Zarate C. The role of disassociation in ketamine’s anti-depressant effects. Nature Communications . 2020: 6431 Bobo W...

References: Cheung T. COMPASS Announces Positive Outcome of 25 mg COMP360 Psilocybin Therapy as Adjunct to SSRI Anti-depressant in Open-Label, Treatment-Resistant Depression Study. COMPASS Health. 13 Dec 2021 [press release]. Grinspoon P. The Popularity of Microdosing of Psychedelics: What Does the Science Say? Harvard Health. 19 Sept 2022. Gukasyan N, et al. Attenuation of Psilocybin Mushroom Eff...

References: Structural comparison of DMT, psilocin, and serotonin. Adkins A and Ferguson MC. “Research update: MDMA and psilocybin for pain management.” Practical Pain Management . 18 June 2022. https://www.practicalpainmanagement.com/news/research-update-mdma-and-psilocybin-for-pain-management. Accessed 30 July 2023 Bornemann J, et al. “Self-medication for chronic pain using class psychedelics: A...

George Sellhorn Ph. D, is the founder, owner and Principal Scientist of Flourish Labs in Portland Oregon and earned his Ph. D. in Molecular Plant Sciences from Washington State University (2006) and his B.S. in Biology from Indiana University (1999). George has worked in both academia and the biotechnology industries from 2006-2021 working on projects such as HIV vaccine development, production, c...

Notes: Per Christopher Toney, a reminder that psilocybin dosing is based on dry weight of the whole mushrooms, for those curious about how dosing is calculated. How well does this approximate actual psilocybin content? This will be a good future topic for discussion. References: Link to FDA’s Considerations for Clinical Investigations of Psychedelic Drugs (Accessed 11 July 2023): https://www.fda.g...

References: Gotvaldova K, et al. "Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids" . International Journal of Molecular Sciences . 2023 (22): 14068. Halpern J, Roth BL "Hallucinogens and dissociative agents naturally growing in the United States". Pharmacology & Therapeutics . 2004; 102 (2): 131–8. Huberman A. The science of MDMA and its therapeutic...

***Disclaimer: this podcast is intended for informational purposes only on the safety and efficacy data of the substances discussed. As healthcare professionals, we do not advocate for or against the use of substances which are considered illicit by the United States Drug Enforcement Administration*** References: Bonson KR, et al. Chronic administration of serotonergic anti-depressants attenuates...

Audio Correction: Colby misspoke 4:15: meant to say “Methergine is used for postpartum hemorrhage after delivery,” said “hemorrhage after bleeding” (which of course is redundant and a mistake). Article on Ergotamine association with the Salem Witch Trials (from the Outside Hustle, Colby’s other blog): Blotter Art examples: https://keseyblotterart.com/ References: Bryant C, Clark J. “How LSD Works....

Introducing the Neural Pharm Podcast, featuring your hosts Colby Burns, PharmD, and Christopher Toney, PharmD. Episode 1 establishes the mission of the podcast, and covers the groundbreaking MAPP1 and MAPP2 trials that established MDMA as a breakthrough therapy for PTSD. We also cover key safety data including drug interactions, pharmacokinetics (or metabolism), and pharmacogenomics (or gene-drug...