Medspeak by CMJ

How can long-lived naked mole-rats help us develop novel anti-aging therapies? In this episode, we speak with Professor Zhiyong Mao from the School of Life Sciences and Technology, Tongji University, who explains how comparative biology helps to reveal the molecular secrets behind longevity in long-lived animals. We explore how naked mole-rats maintain genomic stability and delay cellular senescen...

Can better approaches for suppressing gastric acid improve outcomes in patients with Helicobacter pylori infection? In this episode, Dr. Zhiqiang Song from the Department of Gastroenterology, Peking University Third Hospital, China, explains how potassium-competitive acid blockers (P-CABs)—therapeutics capable of more sustained gastric acid suppression compared to proton pump inhibitors (PPI)—may...

What makes some stroke cases more severe than others, and what can be done to improve outcomes? In this episode of Medspeak by the Chinese Medical Journal , Dr. Wu Simiao and Dr. Craig S. Anderson discuss their recent study on severe acute ischemic stroke. Drawing on data from over 4,000 patients in China, they explore why some people with stroke decline quickly, which treatments show the most pro...

Will the humanized monoclonal antibody CM310 transform treatment outcomes for patients with atopic dermatitis?    In this episode, we speak with Dr. Jianzhong Zhang, Professor at Peking University People’s Hospital, who introduces a breakthrough drug for atopic dermatitis called CM310 and discusses its potential to improve the quality of life for patients living with this chronic skin condition. I...

Can cardiovascular health (CVH) assessment based on Life’s Essential 8 framework help prevent non-communicable diseases?   In this episode, we speak with Dr. Ningjian Wang, Professor at the School of Medicine, Shanghai Jiao Tong University, who explains the American Heart Association’s cardiovascular health framework called ‘Life’s Essential 8’ and its association with the risk of non-communicable...

Is mass drug administration effective against trachoma—a devastating infectious disease that causes blindness—in endemic countries?    We speak with Dr. Tao Xiong, Professor in the Department of Pediatrics from West China Second University Hospital at Sichuan University, who attempts to address this question in a recent systematic review of the current evidence, and discusses how mass drug adminis...

How do environmental factors influence the onset or incidence of diseases that have a strong genetic component?  We speak with Yongna Yao, Research Intern at the National Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, as she gives us some interesting insights into how the incidence of congenital hypothyroidism in China varies with geography and o...