Medical Digest & Congress Report

Professor Oliver Sartor highlights findings from the phase 3 PSMAfore trial exploring 177Lu-PSMA-617 in patients with taxane-naive metastatic castration-resistant prostate cancer. Video: https://medicaldigest.org/scientific-contents/interview:psmafore-study-unveils-game-changing-results-prostate-cancer-treatment

Professor Giorgio Walter Canonica sharing his insights on moderate asthma treatment. The professor will give answers to questions such as: - According to the current GINA recommendation, there are 2 different tracks of asthma management: the ICS/formoterol MART is preferred over the ICS/LABA+ SABA regimen. Are the recommendations reflected in every day practice? - If the physician chooses the firs...

Professor Theresa McDonagh discusses how to deal with the legacy of COVID-19 for our patients and shares her advices. Video: https://medicaldigest.org/scientific-contents/interview:heart-failure-management-post-covid-era-lessons-pandemic

Professor Marco Metra was the co-chairman of the update to the ESC Heart Failure guidelines of 2021. The update incorporate data from nearly a dozen new clinical trials published since 2021, including EMPEROR-Preserved, DELIVER, STRONG-HF, IRONMAN, and more. The new guidelines include new recommendations related to SGLT2 inhibitor use in patients with heart failure with mildly reduced ejection fra...

Professor Mikhail Kosiborod explains the findings of the Meta-Analysis, shows SGLT2 inhibitors do not reduce 28-day mortality in hospitalized COVID-19 patients. These findings do not support the use of SGLT2 inhibitors as standard care in this clinical setting. Video: https://medicaldigest.org/scientific-contents/interview:prospective-meta-analysis-sglt2-inhibitor-randomized-trials-covid-19

Professor Panos Vardas highlights the economic burden of cardiovascular diseases in the European Union. CVD cost the EU an estimated €282 billion in 2021, according to late breaking research presented at ESC Congress 2023. Video: https://medicaldigest.org/scientific-contents/interview:burden-cardiovascular-disease-european-union

Professor Carlos Aguiar discusses the highlights of the ESC2023 annual congress, shares his thougths on many great news, novelties that could be changing the way we practice medicine, but also about findings that would be advancing our understanding on the mechanism of CV diseases. This year's ESC congress focused on Heart Failure, he explains the results of trials like STEP HFpEF, CASTLE-HTx...

Professor Nikolaus Marx, was the co-chairman of the new European Society of Cardiology Guidelines of the Management of Cardiovascular Disease in Patients with Diabetes. A key change from the previous 2019 edition is that the 2023 guidelines only focus on CVD and diabetes, and do not consider pre-diabetes due to the lack of clear evidence. Another important concept modification is the way that CV r...

Professor Theresa McDonagh was the co-chair of the update to the ESC Heart Failure guidelines of 2021 which incorporates data from nearly a dozen new clinical trials published since 2021, including EMPEROR-Preserved, DELIVER, STRONG-HF, IRONMAN, and more. The new guidelines include new recommendations related to SGLT2 inhibitor use in patients with heart failure with mildly reduced ejection fracti...

Professor Mikhail Kosiborod provides a summary of the STEP HFpEF trial, in which semaglutide improves heart failure-related symptoms and physical function and results in greater weight loss compared with placebo in patients with heart failure with preserved ejection fraction and obesity, according to late breaking research presented at ESC Congress 2023. Video: https://medicaldigest.org/scientific...

Professor Luis Henrique Gowdak share his thought how to treat patients optimally with chronic coronary syndromes in 2023. Video: https://medicaldigest.org/scientific-contents/interview:when-real-world-data-meet-real-patients-needs-how-optimally-treat-patients-chronic-coronary-syndromes-2023

Professor Gregg Stone provides a summary from a real-time updated network meta-analysis comparing OCT, IVUS and Angiography guidance in percutaneous coronary intervention procedures. The OCTOBER and ILUMIEN IV randomised trials both studied OCT-guided versus angiography-guided PCI. This analysis compared the overall effects of intravascular imaging in improving outcomes of the PCI procedure as com...

Professor Michael A. Borger, was the co-chairman of the new European Society of Cardiology Guidelines for the Management of Endocarditis. The overarching aim of this guideline is to provide a guide to the diagnostic approach to cardiomyopathies, highlight general evaluation and management issues, and make the reader aware of the relevant evidence base for the recommendations. You can access the do...

Professor Zachary Cox provides a summary of the DICTATE-AHF trial which showed that in patients with ADHF requiring inpatient IV loop diuretic therapy, there was a trend toward increased diuretic efficiency with the addition of dapagliflozin compared with placebo. Video: https://medicaldigest.org/scientific-contents/interview:dictate-ahf-early-dapagliflozin-initiation-acute-heart-failure

Professor Robert Mentz provides a summary of the HEART-FID trial. The study investigated the long-term safety and efficacy of supplementing heart failure patients with iv iron. There was no significant difference between ferric carboxymaltose and placebo in the primary composite outcome, including death, heart failure hospitalizations, and a six-minute walk distance. Video: https://medicaldigest.o...

Professor Bela Merkely provides a summary of the BUDAPEST CRT Upgrade trial. The randomized, multicenre study shows, that among patients with heart failure with reduced ejection fraction, a previously implanted pacemaker or ICD, and a significant RV pacing burden, upgrading to cardiac resynchronization therapy defibrillator provides statistically significant and clinically relevant improvement in...

Professor Borja Ibanez co-chaired of the new 2023 European Society of Cardiology Guidelines for the Management of Acute Coronary Syndromes. This is the first time an “ACS” guideline has been published encompassing the full spectrum of the syndrome including unstable angina, non ST- elevation myocardial infarction and ST elevation myocardial infarction. You can access the document on the ESC websit...

Professor Massimo Federici, was the co-chairman of the new European Society of Cardiology Guidelines of the Management of Cardiovascular Disease in Patients with Diabetes. A key change from the previous 2019 edition is that the 2023 guidelines only focus on CVD and diabetes, and do not consider pre-diabetes due to the lack of clear evidence. Another important concept modification is the way that C...

Professor Juan Pablo Kaski co-chaired the brand new European Society of Cardiology Guidelines for the Management of Cardiomyopathies. This is the first international guideline document to include all cardiomyopathy subtypes, and the first time that specific recommendations are made for cardiomyopathies other than hypertrophic cardiomyopathy. You can access the document on the ESC website by clicki...

Professor Josep Redon shares his insights on the special issues the European Society of Hypertension Guidelines covers, focusing on the best treatment options for patients with type-2 diabetes. Video: https://medicaldigest.org/scientific-contents/interview:what-optimal-treatment-hypertension-diabetics-esh-2023-hypertension-guidelines-diabetes

Professor Peter Nilsson held a lecture on the cardiovascular effects of SGLT-2 inhibitors and GLP-1 agonists, the two new drug classes which revolutionized the treatment of type-2 diabetes at the recent Annual Congress of the European Society of Hypertension. According to the results: - SGLT-2 inhibitors and GLP-1 receptor agonists are mostly safe, well-proven and effective drugs to prevent CVD co...

Professor Sverre Erik Kjeldsen explains how the role of the beta-blockers changed a in the new ESH Hypertension guideline. Video: https://medicaldigest.org/scientific-contents/interview:rehabilitation-beta-blockers-esh-hypertension-guidelines

Professor Otavio Berwanger shares his insight related to the management of patients with hypertension and diabetes. Video: https://medicaldigest.org/scientific-contents/interview:hypertensive-patients-diabetes-are-raasdiuretic-combinations-foundation-treatment

Professor Gianfranco Parati shares his insight on the new ESH Hypertension guidelines, how we should better manage hypertension in our patients. Video: https://medicaldigest.org/scientific-contents/interview:managing-hypertension-real-practice-new-esh2023-hypertension-guidelines

Professor Claudio Borghi on the elevated uric acid levels in hypertension. Which patient should be treated, when and how? Video: https://medicaldigest.org/scientific-contents/interview:hyperuricemia-hypertensive-patients