MCAT Basics (from MedSchoolCoach)

In this episode, we explore key topics in genetics, including how sex-linked and autosomal traits are inherited. We'll break down inheritance patterns using real-world examples, like X-linked recessive diseases, and walk through Punnett square problems to show how these traits are passed down. We also cover the regulation of gene expression, focusing on epigenetic changes such as DNA methylation a...

Mastering the concept of sociological groups can unlock a deeper understanding of how we interact and influence each other. On top of that, social interactions and group dynamics form the backbone of the Psych/Soc section of the MCAT, so mastering this topic is key to a good score.  In this episode, host Sam Smith breaks down the essential topic of sociological groups. You’ll gain a comprehensive...

In this episode, Sam Smith will discuss and help you understand the essential organic chemistry mechanisms and reactions you may encounter when taking the MCAT. From nucleophilic substitution reactions like SN1 and SN2 to aldol condensation and oxidation and reduction of alcohols, Sam will cover the high-yield topics that are crucial for your test prep. He will also touch on key IR and NMR values...

Understanding study design and research variables is crucial for mastering the MCAT and in medical research. In this episode, host Sam Smith discusses the essentials of study design and research methods, from understanding independent and dependent variables to navigating the complexities of correlation, causation, and confounding variables. You’ll learn about the different types of studies, inclu...

In this episode, we're diving deep into the nuanced aspects of metabolism that are essential yet less prominently featured on the MCAT. We'll cover gluconeogenesis, the pentose phosphate pathway, and ketone body generation—topics that, while subtle, play a crucial role in your comprehensive understanding of biochemistry.  We'll explore how your body manages glucose levels, the functions of NADPH,...

In this episode, we’ll learn the intricate world of biomolecule structure, naming, and function. We'll explore the structural nuances between glucose and fructose and unravel the complexities of glycosidic linkages in sucrose. We'll also examine the vital roles of fatty acids, the composition of triglycerides and phospholipids, and their impact on cell membrane architecture and fluidity. Plus, we...

In this episode, we explore enzyme kinetics and inhibition, key concepts for the MCAT Bio/Biochem section. We’ll cover how enzymes accelerate biological reactions by lowering activation energy and introduce two models for enzyme-substrate interaction: the lock-and-key model and the induced fit model. You'll learn how to apply the Michaelis-Menten equation, focusing on factors like Km and Vmax to u...

In this episode, we cover the foundational concepts of genetics, focusing on chromosomes, mitosis, meiosis, and inheritance patterns—important topics for the MCAT Bio/Biochem section. We’ll discuss how Gregor Mendel’s laws of segregation, independent assortment, and dominance influence inheritance and how Charles Darwin’s theory of natural selection relates to modern genetics. The episode includes...

In this episode, Sam Smith covers the intricacies of metabolism, focusing on glycolysis, the Krebs cycle, and the electron transport chain.  First, the podcast explores the process of glycolysis, breaking down the key enzymes, intermediates, and regulation points. Next is the citric acid cycle, examining its regulation, energy production, and the roles of specific enzymes and intermediates. Lastly...

Acids and bases are foundational topics in chemistry, crucial for understanding various biological and chemical systems you'll encounter in the MCAT. In this episode, host Sam Smith discusses the selection and use of indicators in titrations to the pH at the equivalence point and the importance of buffers in maintaining physiological pH levels. You'll learn about the Henderson-Hasselbalch equation...

A foundational topic for the MCAT is the nervous system, appearing in several exam sections and impacting everything from neurotransmission to brain structure. In this episode, Sam Smith walks us through the nervous system, covering its major components and functions. From the organization of the central and peripheral nervous systems to neurotransmitters and brain structures, Sam provides clear e...

Amino acids are the building blocks of life and an essential topic for the MCAT. In this episode, host Sam Smith takes us through the key concepts of amino acids, including their structures, naming conventions, and roles in protein formation. We’ll cover the differences between hydrophobic and hydrophilic amino acids, how to memorize single-letter abbreviations, and the importance of charged amino...

This MCAT BAsics episode covers the muscular system. It begins with the differences and similarities between the three types of muscle (smooth, cardiac, and skeletal). Then, the podcast explores the basic structure of a skeletal muscle cell and the various organelles unique to this cell type, including the sarcolemma, sarcoplasm, myofibrils, sarcomeres, and more. Next, it discusses three main diff...

This MCAT Basics episode covers fluid statics (fluids standing still). It begins with different fluid properties, including surface tension, vapor pressure, adsorption and absorption, adhesion and cohesion, and Henry's law. Next, it discusses several important fluid statics concepts: static fluid pressure, Pascal's law, gauge pressure vs absolute pressure, osmotic pressure, and buoyancy.   For inf...

The electron transport chain is a fundamental pathway in biochemistry, critical for understanding the energy production that powers cellular function. In this episode, guest host Alex Starks breaks down the intricate process of the electron transport chain (ETC). Building on previous discussions of glucose metabolism, Alex walks through the components that play key roles in the movement of electro...

One of the body's key survival mechanisms is gluconeogenesis, a vital metabolic process, and the body's clever way of making glucose when supplies are low. On this episode of the MCAT Basics podcast, guest host Alex Starks walks through the process of gluconeogenesis. He explains how the body generates glucose when levels drop. Highlighting the liver's role, Alex explains how amino acids, lactate,...

In this episode, we delve into three common types of isomers that you are likely to encounter on the MCAT: structural isomers, geometric isomers, and stereoisomers.  We start by defining each type of isomer, providing clear and concise explanations to ensure a solid understanding. Next, we present common examples of each isomer type to illustrate their unique characteristics. Finally, we discuss r...

In this episode, we explore the different phases of the cell cycle: Interphase (G1, S, G2) and the M phase (mitosis). Next, we discuss the regulation of the cell cycle and the key checkpoints that ensure its proper progression. Finally, we touch on how dysfunction in the cell cycle can lead to diseases, particularly cancer. This material is likely to appear in the Bio/Biochem section of the MCAT....

In this episode, we delve into classic psychology experiments –relevant to the Psych/Soc section of the MCAT. We cover a range of significant studies, including Pavlov’s Dog, Harlow’s Monkey Study, Albert’s Bobo Doll Experiment, the Skinner Box Experiment, Asch’s Conformity (Line) Experiment, the Milgram Experiment, Watson’s Little Albert Experiment, Sherif’s Robbers Cave Study, and Seligman’s Lea...

This MCAT podcast covers social stratification. It begins with a definition and examples of many terms related to social stratification and inequality, including prejudice, discrimination, stereotype, stereotype threat, status (ascribed vs achieved), power (six different types to know), social capital (and other forms of capital), gentrification, and poverty. The discussion then moves on to social...

This podcast explores cell organelles, organized into five categories: organelles found in all cells, eukaryotic cells, plant and bacterial cells, human and bacterial cells, human cells only, and plant cells only. The organelles discussed include ribosomes, vacuoles, cytoskeleton, plasma membrane, peroxisome, proteasome, nucleus, nucleolus, smooth and rough endoplasmic reticulum, Golgi apparatus,...

This podcast addresses translational motion. First, vectors are covered. Then, the variables of acceleration, velocity, and position are discussed. Next, the host discusses the relationship between those three variables. Finally, it covers free fall, projectile motion, air resistance, and friction. The example link for this segment is provided here:  Geogebra Example Visit MedSchoolCoach.com for m...

In this episode, we focus on the cardiovascular system and its connection to fluid mechanics. Beginning with an exploration of cardiovascular anatomy, the discussion covers various aspects of the heart: its function, contraction mechanism, the diverse cell types found within it, and its essential role in regulating blood pressure.  Finally, in the latter part of the episode, several fluid mechanic...

In this episode, we cover motivation and emotion–key concepts that will show up in the Psychological, Social, and Biological Foundations of Behavior section of the MCAT. We start with the difference between intrinsic and extrinsic motivation. We then go into various theories including evolutionary, arousal, drive-reduction, incentive, three needs theory, Maslow’s hierarchy, and the correlation bet...

This MCAT podcast covers the respiratory system. First, I cover the anatomy of the respiratory system. Then, I dive into its main functions: Gas exchange (breathing mechanisms here too) Thermoregulation Particle filtration pH control Lastly I talk about how the respiratory system is controlled. Please email me if you have any comments or concerns: MCATpodcast@medschoolcoach.com To learn more about...