Mastering Nutrition

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Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt   Plenty more at https://chri...

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt   Plenty more at https://chri...

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt   Plenty more at https://chri...

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt   Plenty more at https://chri...

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt   Plenty more at https://chri...

Question: Do some people do well on ketosis because they have defective glucose metabolism? I doubt that that's the majority of people that feel good in ketosis, but certainly people with GLUT1 defects need to be on a low-glycemic index diet at least, if not a keto diet in order to not have seizures, and that's the best example of what would fit with that. People who do poorly with glucose, maybe...

Question: What to do when different folate markers don't line up You know, if you have high figlu on the NutrEval, which is Formiminoglutamic acid, which rises when there is Tetrahydrofolate THF, unmethylated folate, to metabolize figlu, and in that case, I would be thinking about maybe you have a B12 deficiency that is leading to the trapping of folate as the methylfolate form, so that THF isn't...

Question: Can sulforaphane hurt the thyroid? What I can say is that sulforaphane does generate thiocyanate ions, which do inhibit uptake of iodine into the thyroid and mammary glands. Although that is a matter of the ratio between isothiocyanate, or between thiocyanate ions and iodine. And so in principle, most uses of sulforaphane, in the context of adequate iodine shouldn't be an issue. I believ...

Question: Are the PUFAs in phosphatidylcholine supplements a concern? I don't think so. I think that you're looking at fairly low levels of PUFAs in there, but the way that I see it is yes, we want to restrict PUFA beyond what's needed, but what's needed is defined by what do we need to get our essential nutrients in. If you would like to be part of the next live Ask Me Anything About Nutrition, s...

Question: Is dairy safe for overmethylators? There's so little methylcobalamin in milk that I think that it is totally insignificant with regards to methyl groups, coming into the methylation cycle. Generally, if you're experiencing over-methylation symptoms from methylcobalamin or methylfolate, I think the big issue is partly that you don't have enough glycine in the system, very likely, and part...

Question: Should different macronutrients be eaten at different times of day? No, I don't agree with the principle. I think you want protein spaced out at every meal. And that's because your efficiency in extracting protein for muscle synthesis is limited in any given hour or any given unit time. And so you need a lot more protein if you're going to put all your protein in one meal, then you are n...

Question: Is it OK to take two milligrams a day of MK-4? Two milligrams, I don't have major safety concerns over, but I would prefer for most people who aren't dealing with a clinical soft-tissue calcification issue take more like 200 micrograms. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom s...

Question: How to feel great on a poor night's sleep? I would say get rid of the poor night's sleep. And so that's go through the checklist of two to four hours of blue light blocking before bed, up to two to four hour, depending on your needs, psychological winding down routine, in which you clear everything off your to-do list, everything off your problem-solving list, focus on a paperback fictio...

Question: What supplements should be taken by someone on PPIs? I would first consider what you should do to get off the PPI. And so PPIs Are targeting stomach acid. And so I would first and foremost be thinking of excess histamine might be leading to excess stomach acid. You should probably try to eat a higher-protein diet, unless you're getting negative consequences from poor protein digestion. B...

Question: Could methylglyoxal be causing elevated fasting glucose in low-carbers? Yes. I did my doctoral dissertation on methylglyoxal so I've covered it in a lot of different contexts, and the basic story is we know that diabetics have high methylglyoxal levels. We know that diabetics have high methylglyoxal-derived advanced glycation endproducts. And we know that this is true even when they're t...

Question: Is it important to hit the AI for total omega-6? I think it's totally normal to not meet the AI for Omega-6 and to exceed the AI for Omega-3. Question is really, if you have systemic inflammation going on, you frame this as, should I strive to at least meet the AI for Omega-6 if I have chronic disease/inflammation? Well, if you have chronic disease/inflammation, you might be depleting yo...

Question: How 30 minutes on the elliptical helps my head and neck tension So what the elliptical does is, it doesn't do a whole lot for moving my neck one way or another, but it does a lot for moving my thoracic spine and my shoulders through a pretty defined range of motion, not full range of motion going like this is, but it's a lot of movement through a considerable amount of that range of moti...

Question: Why does it take time to be fat-adapted when our body already knows how to burn fat? So the body does need time to get fat-adapted because yeah, the body knows how to burn fat, but fat adaptation is not about the body knowing how to burn fat, it's about the body increasing the expression of enzymes involved in burning fat. So everything that you do in the body requires enzymes. Enzymes a...

Question: What should someone with FH eat if they also have prediabetes? So first of all, it's a separable component of the diet so you need a low-saturated fat, low-cholesterol diet without necessarily eating a low-fat diet. Then second of all, the effect of that on blood lipids is dependent on the healthfulness of your insulin pathway. And so over time, that's something where you can play the ba...

Question: How should I take zinc if it makes me nauseous? As far as I know, there's no relationship between the nausea and zinc deficiency. I could be wrong, maybe there's research on it I haven't seen or it could be not researched but I don't think there's a connection. My guess would be that that is either related to her ionizing it faster in the GI tract than you, or something else related to h...

Question: Can familial hypercholesterolemia be managed without statins? I think there's the general perspective that there's no point in having LDL-C be any higher than 50; therefore, since it doesn't matter, let's provide a sufficient margin of error where we're real confident that getting it down to 100 is great and so why not get it down to 50? If there is any extra protection we get it and we...

Question: Is this a biotin deficiency? Beta-hydroxyisovaleric acid is well-established to be the most sensitive marker of biotin status. And actually typically it's done after leucine challenge, which is, no one does that. And so, generally in my experience, the way they have the reference ranges set on that should, on the ones that do have it, so the ION panel has it, the Genova panel has it, and...

Question: Why do vitamin E requirements stay elevated for four years when we stop eating PUFA? None of this really proves that long-term vitamin E status is compromised, and that will make the clinical effect of PUFA be net negative after four or five years. But it does show you that the general relationship between the fact that you get more vitamin E when you eat PUFA oils, right? Because in the...

Question: How long should our fasting windows be? I think someone who eats three meals a day and no snacking is doing a form of intermittent fasting that most people aren't doing. And I don't even have a basis for believing whether that is superior, inferior, or the same as one meal a day in a 20 hour, four-hour feeding window. And so I think it's very clear that you want to cycle through the fed...