Live Longer World

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev  Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab.  We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connect...

Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.  In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic die...

Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology.   His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has importan...

Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lif...

Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming.    Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian...

Dr. Peter Adams , Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contribu...

My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease.  In today’s conversation, we discussed the science behind a dysfunctional mit...

My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock b...

My guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation,...

My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas!    Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerat...

My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research.  Dr. Kennedy's lab is working on different small molecules and natu...

My guest today is Dr. Collin Ewald who is a professor at the Health Sciences department at ETH Zurich. His lab focuses on understanding the extracellular matrix (ECM) and how it changes with age. Collin explains the role of the ECM in tissue repair, muscle strength, and overall longevity. In fact, Collin’s lab is also working on establishing the ECM as a biomarker for health and disease risk. So,...

My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley.  Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old...

Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging.  Dr. Barzilai’s...

The final 2021 episode of the Live Longer World podcast is a rather special one. I've compiled some of the best & most informative parts of each of my previous episodes and highlighted them in this finale episode.   Think of it as a tour showcasing some of the work being done in the field of longevity. Some topics included in the clips are Inflammaging, SystemsAge Clock, Reprogrammin...

Dr. Morgan Levine is an Assistant Professor of Pathology and Epidemiology at the Yale School of Medicine. Morgan runs the lab for Aging in Living Systems at Yale. Her labs works on Epigenetic Clocks , Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer’s disease. I can’t even begin to tell you how much I learned in today’s conversation! We ext...

Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life.   Matt has been around the field of aging for a long time and...

My guest today is David Gobel who is the co-founder & CEO of the Methuselah foundation. Methuselah foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. I’m definitely rooting for that! Dave was an entrepreneur before he decided to jump into the field of longevity. In my conversation...

Carolina Reis Oliveira is the founder & CEO of OneSkin Technologies . OneSkin is pioneering technologies aimed at extending human healthspan. Their first product is a topical supplement designed to extend your skinspan by improving skin health and skin strength. Their proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular level and effectively treat the negative impl...

Jean M. Hébert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine in New York. Dr. Hebert was fascinated from a young age by how a single cell forms the whole human body following an innate genetic program and he got excited by how knowledge of this process might be used to improve our biological fates and defeat aging. He is a molecular geneticist by trai...

Reason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. More than 5 million people die every year due to ath...

"Can I really live to be 200? Can I feel like I’m 20 when I’m 70? Can aging be reversed? Hold up, what even is aging? Now I’m curious to know about aging and longevity science!" Well then, you're at the right spot! Hello and welcome to Live Longer World! The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. We take you right where the action...