Live Longer World

97-Year-Old Brain Scientist Professor Michael Crawford reveals why the human brain has been physically shrinking for thousands of years, why he believes it was DHA, an omega-3 fat from the sea, and not your genes, that built human intelligence, and why the official advice to limit fish in pregnancy may be harming an entire generation of babies! Professor Michael Crawford is Director of the Institu...

Is a hidden molecule in your food and water silently fueling cancer, Alzheimer's, and Parkinson's? Could the supplements you trust every day be making it worse? Dr. Stephanie Seneff is a senior research scientist at MIT (published in PNAS, Frontiers, FASEB) with a career studying nutrition, biology, and toxicology. In this conversation, she explains why deuterium — a heavier form of hydrog...

The standard “wear and tear” story of aging may be incomplete. Dr. Peter Lidsky —a virologist and evolutionary biologist argues that aging is programmed. He says aging can be an adaptive strategy for controlling pathogens, a concept he calls the “pathogen control hypothesis.” In this episode, we dig into the evidence behind this idea, the immune system in aging, and what his theory means for longe...

“We can use the rule of evolution to optimize cancer therapy. The standard practice is that any therapy is given at maximum tolerated dose continuously until progression. It's almost a mantra that they have. Evolutionarily, you could hardly do it worse.” The current treatments on cancer do not account for how evolution works. Dr. Robert Gatenby has been studying evolutionary and game theory dy...

Mitochondria might be one of the most important organelles inside our cells. Best known as the cell’s powerhouse, they don’t just make energy; they regulate metabolism, control cell death, drive immune function, and may even be the reason multicellular life exists at all! It’s no surprise they’re implicated in nearly every major disease, from heart disease and cancer to neurodegeneration, especial...

Can we detect cancer so early such that we find the very first cell of cancer? Not just stage 1 cancer, but the first cell of cancer. In this episode, Dr. Michael Levin and I speak with Dr. Azra Raza. She is an oncologist pioneering early detection of cancer using electric signals. So far, our best solution to curing cancer has been to detect it early, and she wants to take this further, by nippin...

What if chronic diseases like cancer and Alzheimer’s are caused by infections we’ve overlooked? We assume chronic disease is caused by genetics and / or lifestyle. However, evolutionary biologist Dr. Paul Ewald says latent viruses and pathogens play a critical hidden role in many diseases. For example, we already know that Human Papillomavirus (HPV) causes cervical cancer. And research indicates h...

What if our cells have memory and cognition, which changes how medicine is done? In this conversation with Dr. Pamela Lyon and Dr. Michael Levin, we discuss: - Cognition and creativity is not merely associated with the brain and nervous system - Implications of this view of cognition for regenerative medicine and longevity - Is stress response the source of our creativity? Episode Show Notes: http...

We’re only just waking up to the benefits of sunlight and red light for mitochondrial health, lowering blood glucose, and potentially treating Parkinson’s disease and cancer. Dr. Glen Jeffery is at the leading edge of this research. We discuss: - Health benefits of sunlight and red light - Harmful effects of blue light & LEDs - In the 2nd half of the podcast, I ask him rapid fire practical que...

Dr. Thomas Seyfried challenges the existing paradigm that says cancer is a genetic disease. He says that instead cancer is caused by damage to the mitochondria. Understanding this completely overturns the management and prevention of cancer. He is a Professor of biology, genetics, and biochemistry at Boston College. He has over 150 peer-reviewed publications and is also the author of books such as...

Denis Noble and Michael Levin - two great minds in biology come together on Live Longer World. Denis Noble is a renowned biologist and pioneer in systems biology, known for his groundbreaking work on the electrical activity of the heart and his influential contributions to the understanding of biological systems. Denis is an advocate for taking a systems integrative approach to biology, as opposed...

This interview is part of my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity. Dr. Mustafa Djamgoz was one of the first people to study the role of ion channels and bioelectricity in cancer, which he initially documented in a 1995 paper. His research showed that there was an uptake in voltage-gated sodium channels in all types of ca...

Dr. Alfonso Martinez Arias is a development biologist and the author of the book The Master Builder: How the New Science of the Cell Is Rewriting the Story of Life. He also co-authored the biology textbook Principles of Development, which was awarded the Royal Society of Biology book prize. Episode Show Notes: https://livelongerworld.com/p/aarias OVERVIEW: Each of our cells has the same DNA. Yet t...

The following is a fascinating interview with Dr. Charley Lineweaver, who worked with Paul Davies on his work on cancer which we discuss. Episode Show Notes: https://livelongerworld.com/p/clineweaver Topics include: - the evolutionary and atavistic theory of cancer - the incorrectness of the somatic mutation theory of cancer - a novel take on attacking the weakness of cancer - how embryogenesis co...

This is the third in my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity. Ken Robinson has a long list of accomplishments in the bioelectricity field, covering the role of electric fields in guiding cell migration and more generally the function of electrogenic epithelia in embryogenesis. This is about a ~1 hour conversation in whic...

This is the second of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Min Zhao's work is focused on the role of ion currents and applied electric fields in cell migration and wound repair. Episode Show Notes: https://livelongerworld.com/p/mzhao Find me: https://x.com/aasthajs Background on the bioelectricity series & 1s...

Stephanie Seneff is the pioneer in raising concerns around glyphosate, a chemical and active ingredient in RoundUp and other pesticides, which has practically infiltrated our food system, water bodies, and soil. Glyphosate has been linked to several diseases including liver disease, autoimmunity, neurological disorders, reproductive issues, microbiome problems, and more. Dr. Stephanie Seneff has s...

This is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his backgro...

Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin. We discuss: - The history of the FDA, - The trial of Avastin which got FDA approval in 2008 and revoked in 2011 - FDA's funding mechanisms - FDA ties to big pharma - What c...

Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer. Episode Show Notes: https://livelongerworld...

Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity. Episode Show Notes...

All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad  Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions!    There are many open questions on...

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine...

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1  Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Ma...

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection.  Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” th...