Journal of Clinical Oncology (JCO) Podcast

This podcast discusses the findings from the manuscript by Munster et al. regarding the use of ovarian suppression for fertility preservation in young women receiving adjuvant chemotherapy in the context of the current literature and future directions.

The study by Marin et al is another milestone in our understanding how to manage CML patients on tyrosine kinase inhibitors.

This podcast will summarize the results of Efstathious et al and discuss possible mechanisms of resistance to castration based therapies in prostate cancer.

Targeting the Angiopoietin-Tie2 axis is a promising alternative antiangiogenic strategy for the treatment of ovarian cancer that exhibits non-overlapping toxicities with inhibitors of the VEGF signaling pathway.

This podcast reviews data from a recent publication on the use of "early" interim PET scanning in diffuse large B-cell lymphoma and comments on the clinical utility of this imaging technique in the current management of patients with this disease.

Biopsy of presumed metastatic breast cancer sites confirms the diagnosis in most women and alters therapy in 14% of women in a prospective study of 121 patients but its impact on outcome could not be reliably assessed.

This podcast provides a commentary on the article by Wu et al that addresses disparities in systemic therapy for breast cancer.

This Podcast reviews the background of the MA.17 trial, the results of the present manuscript and provides perspective on the current findings.

This podcast summarizes the findings of this JCO article and provides commentary on its applicability to practice.

This podcast will critically review randomized phase III trial data examining the relative role of taxane monotherapy versus combination therapy as first-line treatment for HER2-negative metastatic breast cancer.

This podcast discusses findings and implications of a recent survey study on attitudes and knowledge about cancer pain among medical oncologists

This podcast will explore the feasibility of a nonoperative "wait and see" approach based on strict selection criteria in patients with locally advanced rectal cancer who achieve a complete clinical response after chemoradiation.

This podcast reviews the evidence that women testing negative for known familial BRCA1/2 mutations should adhere to current population breast cancer screening guidelines.

This Podcast provides observation and commentary on the JCO article "Sequential versus concurrent trastuzumab in adjuvant chemotherapy for breast cancer".

Podcast to review the article "Occult Metastases in Length Nodes Predict Survival In Resectable Non-Small Cell Lung Cancer: Report of the ACOSOG Z40040 Trial" by Rusch et al.

The ATAC investigators collected comorbidity data on more than 9000 women and this article illustrates that it provides key information.

Rapid, dramatic shifts are ongoing in the population-level epidemiology of oropharynx cancer in the United States.

EGFR mutation is a predictive biomarker for maintenance erlotinib but its clinical application is limited. This podcast will explain why.

This podcast summarizes the incidence and long-term outcome of osteonecrosis in a large prospective study of children treated for acute lymphhoblastic leukemia with the dexamethasone-based Dutch Childhood Oncology Group-ALL 9 Protocol.

This podcast evaluates the context and reviews results of a randomized phase III trial comparing R-CHOP given at conventional 21 day intervals with R-CHOP given at 14 day intervals in patients with newly diagnosed follicular lymphoma.

This podcast reviews the randomized double-blind placebo-controlled trial reported by Boekhout et al. that evaluates venlafaxine and clonidine for the treatment of hot flashes in women with breast cancer.

This podcast reviews the retrospective study by Arun et al. and discusses the lack of consensus regarding the relative chemosensitivity of breast cancers in mutation carriers and non-carriers as well as the optimal neoadjuvant chemotherapy for mutation carriers.

Androgen deprivation therapy may not be associated with an increase in cardiovascular mortality in all men but only those with a prior cardiac event due to known coronary artery disease.

Stage II colon cancer with high risk factors is often treated with adjuvant therapy, however new data raise questions about the usefulness of this practice.

Commentary on a successful study in which genotype-guided tamoxifen dosing increased endoxifen concentrations in women with reduced CYP2D6 metabolism.