In the Know with Amol Sarva

Understanding blood sugar and insulin with world leader on diabetes Dr. John Buse of UNC 29.07.2024 42:57 ↓

Metabolic Health is the biggest medical breakthrough of the moment Dr. John Buse has been at the forefront of diabetes research and endocrinology since before the first GLP-1 results started to become known. He studies the body's systems that seem to be at the core of how Ozempic and diabetes operate -- let's learn about the endocrine system and map out these system-level interactions

How weight loss works with Yale’s Dr. Waj Mehal 26.07.2024 36:52 ↓

Metabolic Health is the biggest medical breakthrough of the moment We have one of the world's experts on the liver - the place your body stores lots of energy from food, and distributes it onward to other systems, Dr. Waj Mehal of the Yale School of Medicine. We lay out a map of the systems in digestion and metabolism, weight loss and exercise -- plus the different pathways that GLP-1s like Ozempi...

How Ozempic works and what else could revolutionize metabolic health with James Peyer, Ph.D. of Cambrian Bio 25.07.2024 44:53 ↓

Metabolic Health is the biggest medical breakthrough of the moment Get up to speed on the cellular biology with a fantastic overview from PhD scientist and founder of breakthrough pharma platform Cambrian Bio

Matt Kaeberlein on which longevity supplements might really work, and which don’t 10.07.2023 50:00 ↓

Professor Matt Kaeberlein is an outspoken proponent of rapamycin, and pretty skeptical about virtually all the other interventions people talk most about. Here he lays out a pretty complete and persuasive model for why and how aging happens at all, and why some approaches are most likely to work.

Nir Barzilai on the genes of centenarians and some nuance on metformin 12.12.2022 39:25 ↓

A rare MD at the cutting edge of the longevity field, Dr. Barzilai heads the Institute for Longevity Research at Einstein. We cover his unique contributions, especially the currently buzzy topic of metformin, as well as his work on the genetic luck of centenarians.

Jean Herbert on regenerating the brain in the lab 12.12.2022 35:37 ↓

One of the more incredible research programs in longevity is regeneration: rebuilding and replacing failing organs with lab-grown cells. Jean Herbert at Einstein is working on regenerating your brain.

James Peyer from Cambrian Biosciences and Apollo Health Ventures tells us how to play longevity to win 29.11.2022 52:48 ↓

This founder has been part of so many of the exciting longevity startups, investments, and discussions that you simply must understand the world the way he sees it before taking a view about life extension. In this episode, you will.

Aubrey de Grey, the longevity OG, gives us a peek into the early days of the cult of living forever 10.11.2022 46:44 ↓

Longevity superstar alert. A deep dive with one of the most recognized and longest-serving visionaries of longevity world. After recording this episode, friends pointed out that I didn't cover big important parts of personal history that are covered here: https://en.wikipedia.org/wiki/Aubrey_de_Grey

Vincere Bio’s computer model for solving Parkinson’s with the cofounders Spring Behrouz and Andy Lee 06.11.2022 47:42 ↓

The easy way to attack Parkinson's? A neuron-by-neuron model of the brain.

Altos Labs’ Morgan Levine on how to measure biological age and why she left Yale 08.09.2022 23:48 ↓

Cellular rejuvenation is in the house on this episode, and fundamental research on the processes far beneath the surface of your typical aging research. And a little peek into the billionaire-backed mega-project happening at Altos.

Muneeb Ali, CEO of Blockstack, talks to us about the future network protocol and blockchain 26.03.2020 33:08 ↓

Started a long way off in Pakistan, made it to Princeton among the great inventors of the Internet, and now building the New Internet.