Oxford University

Immunity By Design

Education EN ↓ 5 episodes

From Cells to Systems Through Human and Machine Intelligence. Modern immunology stands at a transformative turning point. Emerging AI and experimental technologies are rapidly reshaping how we do and understand immunology. But this acceleration comes at a cost. A widening gap seems to emerge: those who adapt alongside these changes prove more effective at translating ideas into impact, while even the most brilliant concepts can be consumed by complexity and strategy. And in the middle, a central challenge remains: how do we move beyond pattern recognition to genuine mechanistic understanding?...

Author

Oxford University

Episodes

AI Reveals Hidden Immune Memory in Eczema & Psoriasis | Lloyd Steele | Sanger Institute 01.07.2026 46:38

Can AI uncover what a century of histopathology has missed? Dr Lloyd Steele explains how spatial transcriptomics reveals hidden immune memory niches driving eczema and psoriasis. Artificial intelligence and spatial genomics are transforming how we study human disease, but what happens when they reveal biology that has remained invisible for over a century of conventional histopathology? In this ep...

Beyond Black Boxes: Decoding T Cell Recognition with Interpretable AI 02.06.2026 1:02:05

Professor David Gfeller discusses interpretable AI, TCR specificity profiles, cross-reactivity, chain pairing, and why understanding T cell recognition may matter more than black-box prediction. In this episode of Immunity by Design, Prof Hashem Koohy speaks with Professor David Gfeller (University of Lausanne & Ludwig Institute for Cancer Research) about the emerging rules governing T cell re...

The Hidden Biology of Crohn’s Fistula 22.05.2026 55:46

Dr Agne Antanaviciute joins Prof Hashem Koohy to discuss how spatial omics and single-cell technologies uncovered the hidden biology of Crohn’s fistula and revealed fibroblasts as key drivers of disease. Crohn’s fistula is one of the most severe and understudied complications of inflammatory bowel disease, causing chronic pain, recurrent infection, and profoundly reduced quality of life. Yet for d...

Can AI Solve Snakebite? With Dr Timothy Jenkins 14.04.2026 47:59

Prof Hashem Koohy is joined by Dr Timothy Jenkins to explore how AlphaFold and experimental technologies are transforming antibody discovery, enabling molecules that neutralise multiple snake venom toxins. Snakebite envenoming remains one of the most neglected global health challenges, causing over 100,000 deaths each year, yet antivenom design has changed little in more than a century. In th...

Decoding T Cell Recognition at Scale by Dr Stephanie Gaglione 25.03.2026 47:00

Dr Stephanie Gaglione discusses scalable technologies to map T cell receptor antigen interactions, enabling large datasets that could transform how we study immune recognition and build computational models of immunity. In this episode of 'Immunity by Design', Dr Hashem Koohy speaks with Dr Stephanie Gaglione about new experimental approaches that could transform how we study T cell recognition. A...