Healthy Dialogue

It's been unclear whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. JAMA Deputy Editor Chris Muth, MD, speaks with author Rolf Blauenfeldt, MD, Aarhus University Hospital, Denmark, about the RESIST randomized clinical trial, which looks at the effect of RIC when initiated in the prehospital setting. Related...

During the COVID-19 pandemic, the incidence of diabetes in childhood increased. JAMA Associate Editor Anne R. Cappola, MD, ScM, and Ezio Bonifacio, PhD, from the Center for Regenerative Therapies at the Dresden University of Technology, discuss SARS-CoV-2 infection and its association with islet autoimmunity in early childhood. Related Content: SARS-CoV-2 Infection and Development of Islet Autoimm...

Many premature infants with respiratory distress are now supported with continuous positive airway pressure, or CPAP, rather than intubation and ventilation, and those with CPAP can receive surfactant via a minimally invasive approach. JAMA Associate Editor Tracy Lieu, MD, speaks with author Peter Dargaville, MD, from the Menzies Institute for Medical Research in Tasmania, Australia, about Two-Yea...

There is an established link between sedentary behavior and cardiovascular disease, but the association between sedentary behavior and dementia is unclear. JAMA Deputy Editor Christopher C. Muth, MD, speaks with David A. Raichlen, PhD, University of Southern California, about a new study that investigates the relationship between sedentary behavior and dementia in older adults. Related Content: Se...

In a new study, psilocybin showed promise as a treatment for major depressive disorder (MDD). JAMA Associate Editor Donald C. Goff, MD, speaks with author Charles L. Raison, MD, from the Usona Institute, about the study, as well as Rachel Yehuda, PhD, Mount Sinai School of Medicine, who wrote an accompanying editorial about the potential benefits of psychedelic therapies. Related Content: Single-D...

Magnesium sulfate is widely recommended for neuroprotection in pregnancies at risk of preterm delivery. However, the optimal gestational age for use is unclear. JAMA Associate Editor Melissa Simon, MD, MPH, and Caroline Crowther, MD, Liggins Institute, University of Auckland, discuss the use of magnesium sulfate at different gestational ages and potential benefit vs harms as reflected in the MAGEN...

Anthracyclines are used to treat a variety of cancers, but treatment may be limited by cardiac toxicity. JAMA Executive Editor Gregory Curfman, MD, discusses a new clinical trial on the use of atorvastatin to prevent anthracycline-induced cardiac toxicity with authors Tomas Neilan, MD, MPH, and Marielle Scherrer-Crosbie, MD, PhD. Related Content: Atorvastatin for Anthracycline-Associated Cardiac D...

Cardiovascular health is essential to everyone, but especially important to address in individuals who can become or who are pregnant or postpartum. JAMA Associate Editor Melissa Simon, MD, MPH, and Sadiya S. Khan, MD, MSc, Northwestern University, discuss the importance of cardiovascular health in pregnancy-capable, pregnant, and postpartum persons, how to counsel such individuals, issues of acce...

The performance of whole-genome sequencing in comparison with targeted genomic testing methods is not well understood. In this podcast, JAMA Associate Editor W. Gregory Feero, MD, PHD, interviews author Jill L. Maron, MD, MPH, of the Women and Infants Hospital of Rhode Island about a study of whole-genome sequencing vs a commercially available targeted genetic testing platform for diagnosing ill n...

Bempedoic acid is an effective option for some statin-intolerant patients with an elevated predicted risk of cardiovascular events. However, as JAMA Executive Editor Gregory Curfman, MD, discusses with editorialist Dhruv S. Kazi, MD, MSc, MS, bempedoic acid should not be considered a substitute for statins, which remain the first-line therapy for primary prevention. Related Content: Bempedoic Acid...

Valganciclovir is standard cytomegalovirus (CMV) prophylaxis in high-risk kidney transplant recipients, but its use is limited by myelosuppression. JAMA Deputy Editor Preeti Malani, MD, MSJ, interviews Ajit Limaye, MD, from the University of Washington, about a multinational randomized trial of letermovir vs valganciclovir for CMV prevention in CMV-negative patients receiving a kidney from a CMV-p...

US hospitals report data on numerous quality metrics to government and independent rating organizations, but the cost of doing so is not well known. JAMA Associate Editor Karen E. Joynt Maddox, MD, discusses a new study that examines just how many quality metrics hospitals have to report, and attempts to quantify how much data collection and reporting costs in hours and dollars, with corresponding...

Interview with Michael Silverstein, MD, MPH, USPSTF chair and coauthor of Screening for Depression and Suicide Risk in Adults, and Screening for Anxiety Disorders in Adults: US Preventive Services Task Force Recommendation Statements. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Anxiety Screening Depression and Suicide Risk Screening Screening for Depressi...

The US Black population experienced more than 80 million excess years of life lost compared with the White population over a recent 22-year period. JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, discusses the research that quantified this disparity with authors César Caraballo, MD, Harlan M. Krumholz, MD, SM, and Clyde W. Yancy, MD, MSc. Related Content: Excess Mortality and Years of Poten...

Intentional miscoding of abortion services may put clinicians and hospital systems at legal risk. JAMA Senior Editor Linda Brubaker, MD, MS, and Carmel Shachar, JD, MPH, from the Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard Law School, discuss the risks of intentional miscoding practices and possible penalties. Related Content: Abortion Miscoding—Legal Risks for...

The Covenant of Water, Stanford University professor Dr Abraham Verghese's long-awaited follow-up to his 2009 novel Cutting for Stone, traces the lives of a family in southern India negotiating forces of history, fate, and a genetic condition that takes the life of a member in each generation by drowning. In part 2, JAMA Arts and Medicine Section Editor Michael Berkwits, MD, MSCE, talks with Dr Ve...

The ACA's preventive services mandate requires insurers to cover, without charge, nearly 200 basic primary care services. But now, a federal judge has issued a nationwide injunction preventing the Biden administration from enforcing this cost-free care for a significant number of these services. JAMA Executive Editor Gregory Curfman, MD, discusses this and more with Abbe R. Gluck, JD, Solomon Cent...

Most epidemiological studies of heart failure have been conducted in high-income countries. JAMA Senior Editor Kristin L. Walter, MD, MS, interviews Philip George Joseph, MD, from the Population Health Research Institute, Ontario, Canada, about a study of more than 23 000 patients with heart failure in 40 countries. Related Content: Global Variations in Heart Failure Etiology, Management, and Outc...

Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Latent Tuberculosis Infection in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Latent Tuberculosis Infection in Adults Screening for Latent Tuberculosis Infection Among Non–US-Born Adults in t...

The mental health of young people in the US has been an issue of increased concern in recent years. In this podcast, author Tanner Bommersbach, MD, MPH, assistant professor in the Department of Psychiatry and Psychology at the Mayo Clinic in Rochester, Minnesota, and Greg Rhee, PhD, a health services researcher and pharmacoepidemiologist at the University of Connecticut, join JAMA Senior Editor Kr...

The Covenant of Water, Stanford University professor Dr Abraham Verghese's long-awaited follow-up to his 2009 novel Cutting for Stone, traces the lives of a family in southern India negotiating forces of history, fate, and a genetic condition that takes the life of a member in each generation by drowning. JAMA Arts and Medicine Section Editor Michael Berkwits, MD, MSCE, talks with Dr Verghese abou...

Major medical schools are no longer contributing data to the US News & World Report (USNWR) including more than half the schools that are currently ranked in the top 10 medical schools by the survey. In this podcast, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, speaks with author Holly J. Humphrey, MD, from the Josiah Macy Jr Foundation in New York, about the recently published View...

Differences among countries in how health care is organized could have implications for health equity. JAMA Associate Editor Karen Joynt Maddox, MD, MPH, and Bruce E. Landon, MD, MBA, MSc, professor of health care policy, Harvard Medical School, discuss whether treatment patterns and outcomes for patients presenting with acute myocardial infarction differ for patients with higher vs lower incomes...

JAMA Executive Editor Greg Curfman, MD, speaks with Robert D. Truog, MD, MA, director of the Harvard Center for Bioethics, who describes the 2 approaches to the determination of death (cardiovascular death and brain death) and discusses the possibility that the determination of brain death may soon undergo substantial change, with important implications for organ transplantation. Related Content:...

Mary Arakelyan, MPH, and JoAnna Leyenaar, MD, PhD, MPH, vice chair of Research in Pediatrics at Dartmouth, discuss increases in pediatric mental health hospitalizations and suicide-related diagnoses over the past decade. Hosted by JAMA Associate Editor Tracy Lieu, MD, MPH. Related Content: Pediatric Mental Health Hospitalizations at Acute Care Hospitals in the US, 2009-2019. Related Content: Pedia...