Healthy Dialogue

Gestational age estimation is foundational for obstetric care. In resource-limited settings, an integrated AI tool allows novice users to improve gestational age estimates. Author Jeffrey Stringer, MD, University of North Carolina, joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps. Relat...

Biomarkers for Alzheimer disease (AD) provide insight into disease processes and may aid clinical diagnosis for individuals with cognitive impairment. Author Stephen Salloway, MD, MS, of Brown University joins JAMA Deputy Editor Christopher Muth, MD, to discuss 2 articles and an accompanying editorial about blood biomarkers for AD and potential implications for clinical practice. Related Content:...

Ulcerative colitis can significantly decrease quality of life. A third of patients have persistent symptoms with tumor necrosis factor inhibitors and nearly 1 in 5 patients will be hospitalized within 5 years of diagnosis. Author Gilaad G. Kaplan, MD, MPH, of the University of Calgary joins JAMA Associate Editor John M. Inadomi, MD, to discuss Risankizumab for Ulcerative Colitis. Related Content:...

What are the ovarian cancer risks associated with endometriosis subtypes? Author Karen C. Schliep, PhD, MSPH, of the University of Utah joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Endometriosis Typology and Ovarian Cancer Risk. Related Content: Endometriosis Typology and Ovarian Cancer Risk New Insights in Endometriosis Subtypes and Ovarian Cancer Risk

Oral nicotine pouches are becoming more popular in the US, based on a survey performed in 2022. Hongying Daisy Dai, PhD, from Nebraska Medical Center, Omaha, discusses nicotine pouches and more with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content: Prevalence of Nicotine Pouch Use Among US Adults

Availability of pediatric care is decreasing, despite the growing complexity of pediatric care needs. Match rates for pediatric residency continue to decline. The US risks a serious shortage of pediatricians. Julie Byerley, MD, MPH, executive vice president & chief academic officer, Geisinger, Pennsylvania, discusses this and more with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content: Wh...

Facilitating safe and timely health care for individuals planning medication abortion is a reproductive health care priority. Lauren J. Ralph, PhD, MPH, and Daniel Grossman, MD, of University of California San Francisco join JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Comparison of Effectiveness of No-Test Telehealth and In-Person Medication Abortion. Related Content: Comparison of No-Te...

Can a new ECG finding identify individuals at risk for dying suddenly? Jason D. Roberts, MD, of McMaster University joins JAMA Associate Editor Gregory M. Marcus, MD, MAS, to discuss A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome (CRDS). CRDS is a recently described cause of sudden arrhythmic death. Until now, no clinical test has existed to identify those with the disease. Rel...

Joel M. Dulhunty, MD, PhD, Royal Brisbane and Women's Hospital, and Jason A. Roberts, BPharm, PhD, University of Queensland Centre for Clinical Research, join JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the BLING trial that assessed continuous vs intermittent β-lactam antibiotic infusions in patients with sepsis or septic shock. Related Content: Continuous vs Intermittent β-Lactam Antibi...

Randomized clinical trials (RCTs) frequently fail to generate knowledge relevant to practice, while practice patterns are frequently unsupported by RCT evidence. Derek C. Angus, MD, MPH, of the University of Pittsburgh, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss The Integration of Clinical Trials With the Practice of Medicine: Repairing a House Divided. Related Co...

Forced nitrogen inhalation was used by the state of Alabama to execute Kenneth Smith on January 25, 2024. Some politicians, attorneys general, and health care practitioners support its use for capital punishment in the US. Philip E. Bickler, MD, PhD, and Michael S. Lipnick, MD, discuss the evidence indicating that forced nitrogen inhalation is inhumane with JAMA Executive Editor Gregory Curfman, M...

Guidelines call for better evidence on the health outcomes after living kidney donation. Author Amit X. Garg, MD, PhD, London Health Sciences Centre, and editorialist Elizabeth C. Lorenz, MD, Baylor College of Medicine, discuss a new study that compares the risks of hypertension and other health outcomes in living kidney donors, with JAMA Associate Editor Wolfgang Winkelmayer, MD, ScD. Related Con...

What is the natural history and cardiovascular burden of the V142I transthyretin variant among US Black individuals who carry this variant? Senthil Selvaraj, MD, MS, MA, from Duke University, and Scott D. Solomon, MD, from Brigham and Women's Hospital, discuss this and more with JAMA Executive Editor Gregory Curfman, MD. Related Content: Cardiovascular Burden of the V142I Transthyretin Variant Add...

Between 2019 and 2021, pediatric mortality rates had the largest increases in at least half a century. Steven H. Woolf, MD, MPH, of Virginia Commonwealth University Center on Society and Health, joins JAMA Associate Editor Tracy A. Lieu, MD, MPH, to discuss how racial and ethnic disparities and specific causes have factored into these increases and what this means for policymakers and clinicians....

When initial treatment with varenicline or nicotine replacement doesn't work, does increasing dosage improve smoking cessation rates? Paul Cinciripini, PhD, of MD Anderson Cancer Center's Department of Behavioral Science, joins JAMA Executive Editor Gregory Curfman, MD, to discuss guidance on the best strategies for smoking cessation following an initial quit attempt. Related Content: Smoking Cess...

Extensive evidence documents health disparities for lesbian, gay, and bisexual (LGB) women, including worse physical, mental, and behavioral health than heterosexual women. Sarah McKetta, ScM, MD, PhD, discusses these factors and their link to premature mortality with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content: Disparities in Mortality by Sexual Orientation in a Large, Prospective...

Can real-time EHR–generated recommendations safely reduce antibiotic use in hospitalized patients with pneumonia or UTI? Shruti K. Gohil, MD, MPH, of the University of California-Irvine, joins JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the INSPIRE randomized clinical trial. Related Content: Stewardship Prompts to Improve Antibiotic Selection for Pneumonia Stewardship Prompts to Improve...

Climate action is an urgent public health imperative. Climate change is causing excess morbidity and mortality and posing an increasing threat to mental health and well-being. The US health care sector is a significant contributor to this problem. A. Eugene Washington, MD, of Duke University, discusses accelerating climate action with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Rel...

The utility of prostate-specific antigen (PSA) screening for prostate cancer detection is impacted by detection of cancers with low risk of mortality. Editorialist Jeffrey J. Tosoian, MD, MPH, discusses a pragmatic approach to prostate cancer screening with JAMA Deputy Editor Mary L. (Nora) Disis, MD. Related Content: A Pragmatic Approach to Prostate Cancer Screening Prostate Cancer Screening With...

Infections due to multidrug-resistant organisms (MDROs) are difficult to treat with increased morbidity, mortality, length of hospitalization, and health care costs. Author Susan S. Huang, MD, MPH, from the University of California Irvine School of Medicine, joins JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss a new study that used a regional intervention to prevent MDROs. Related Content:...

The US Supreme Court will soon decide a case challenging the US Food and Drug Administration's (FDA's) approval of mifepristone. Author Holly Fernandez Lynch, JD, MBE, University of Pennsylvania, joins JAMA Executive Editor Gregory Curfman, MD, to discuss the science and politics surrounding this significant case. Related Content: The FDA in the Crosshairs—Science, Politics, and Abortion Provision...

How did GPT-4 Vision, a model that can work with images and text as input, perform when answering clinical challenge questions from medical journals? Daniel Truhn, MD, MSc, of the University Hospital Aachen in Germany, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss this topic. Related Content: Comparative Analysis of Multimodal Large Language Model Performance on Clin...

An observational study by Lin Li, PhD, and colleagues, published in JAMA, found that pharmacotherapy was associated with reduced mortality in individuals with ADHD. Frances R. Levin, MD, of the Columbia Vagelos College of Physicians and Surgeons, who wrote an accompanying editorial, joins JAMA Associate Editor Donald C. Goff, MD, to discuss the results of this article. Related Content: Treating At...

Introducing JAMA's new Communicating Medicine series, JAMA Associate Editor Anne Cappola, MD, ScM, discusses strategies for delivering effective messages in the patient encounter with authors Joseph Cappella, PhD, of the University of Pennsylvania, and Richard Street, PhD, of Texas A&M University and Baylor College of Medicine. Related Content: Delivering Effective Messages in the Patient-Clinicia...

How will new study results inform HIV prevention in the US and globally? JAMA Deputy Editor Preeti Malani, MD, MSJ, and author Jeanne Marrazzo, MD, MPH, director of NIAID, discuss these study findings and more. Related Content: HIV Preexposure Prophylaxis With Emtricitabine and Tenofovir Disoproxil Fumarate Among Cisgender Women