Gradient Dissent: Conversations on AI

"We are going to switch from the problem in AI being that nothing works to the problem being that everything works." Dan Klein has been studying language models for over two decades and is now a professor of computer science at Berkeley. His new company, Scaled Cognition, is built around one question: how do you build a system that will not lie to you? In this episode, Dan joins Lukas Biewald to t...

Samuel Rodriques left physics because there were no unsolved problems left. Instead, he built an AI scientist named Kosmos to cure every disease, solve aging, and map the human brain. In this episode: The cure his AI proposed for blindness Why he would never touch a peptide Whether we'll need human scientists in 20 years What's stopping America in drug discovery Connect with us here: Samuel Rodriq...

"Every vehicle is capable of driverless operation. That's clearly the steady state of where we're going." Wayve started in a rented house in Cambridge with $1.5M, a car in the garage, and an aim to integrate end-to-end AI into driving. A decade later it's driven across 506 cities without a single HD map and is worth over $8.6 billion. In this episode, CEO Alex Kendall joins Lukas Biewald to talk a...

"Companies designing for agents, not humans, are going to get a lot of lift." ClickHouse started as an internal tool at Yandex. Today it's the database Anthropic, OpenAI, Meta and Tesla all run on. In this episode, CEO Aaron Katz joins Lukas Biewald to talk about how he turned an open source project into a $15B company, why he acquired LangFuse knowing it could cost him customers, and what he's ac...

Formal verification already consumes years of human effort. In this episode, Lukas Biewald talks with Carina Hong, Founder & CEO of Axiom, about why verification is becoming the real bottleneck in high stakes AI systems. They discuss how Axiom uses AI to take on the tedious checking that stretches verification cycles across years, starting with formal mathematics and extending to hardware and...

“I don't worry about being replaced by AI. I worry about being replaced by someone who's really good at using AI.” Atlassian has 10,000+ engineers currently split-testing the world’s top AI coding tools, from GitHub Copilot and Cursor to Claude Code. In this episode, Co-Founder & CEO Mike Cannon-Brookes joins Lukas Biewald to share what their data reveals about the world's best AI tools today....

The future of AI training is shaped by one constraint: keeping GPUs fed. In this episode, Lukas Biewald talks with CoreWeave SVP Corey Sanders about why general-purpose clouds start to break down under large-scale AI workloads. According to Corey, the industry is shifting toward a "Neo Cloud" model to handle the unique demands of modern models. They dive into the hardware and software stack requir...

The future of AI is physical. In this episode, Lukas Biewald talks to Nikolaus West, CEO of Rerun, about why the breakthrough required to get AI out of the lab and into the messy real world is blocked by poor data tooling. Nikolaus explains how Rerun solved this by adopting an Entity Component System (ECS), a data model built for games, to handle complex, multimodal, time-aware sensor data. This i...

Is video AI a viable path toward AGI? Runway ML founder Cristóbal Valenzuela joins Lukas Biewald just after Gen 4.5 reached the #1 position on the Video Arena Leaderboard, according to community voting on Artificial Analysis . Lukas examines how a focused research team at Runway outpaced much larger organizations like Google and Meta in one of the most compute-intensive areas of machine learning....

In this episode of Gradient Dissent, Lukas Biewald talks with Tuhin Srivastava, CEO and founder of Baseten, one of the fastest-growing companies in the AI inference ecosystem. Tuhin shares the real story behind Baseten’s rise and how the market finally aligned with the infrastructure they’d spent years building. They get into the core challenges of modern inference, including why dedicated deploym...

In this episode of Gradient Dissent, Lukas Biewald talks with the CEO & founder of Surge AI, the billion-dollar company quietly powering the next generation of frontier LLMs. They discuss Surge's origin story, why traditional data labeling is broken, and how their research-focused approach is reshaping how models are trained. You’ll hear why inter-annotator agreement fails in high-complexity t...

In this episode of Gradient Dissent, Lukas Biewald sits down with Arvind Jain, CEO and founder of Glean. They discuss Glean's evolution from solving enterprise search to building agentic AI tools that understand internal knowledge and workflows. Arvind shares how his early use of transformer models in 2019 laid the foundation for Glean’s success, well before the term "generative AI" was mainstream...

In this episode of Gradient Dissent, Lukas Biewald talks with Jarek Kutylowski, CEO and founder of DeepL, an AI-powered translation company. Jarek shares DeepL’s journey from launching neural machine translation in 2017 to building custom data centers and how small teams can not only take on big players like Google Translate but win. They dive into what makes translation so difficult for AI, why h...

In this episode of Gradient Dissent, Lukas Biewald sits down with Thomas Dohmke, CEO of GitHub, to talk about the future of software engineering in the age of AI. They discuss how GitHub Copilot was built, why agents are reshaping developer workflows, and what it takes to make tools that are not only powerful but also fun. Thomas shares his experience leading GitHub through its $7.5B acquisition b...

In this episode of Gradient Dissent, Lukas Biewald talks with Martin Shkreli — the infamous "pharma bro" turned founder — about his path from hedge fund manager and pharma CEO to convicted felon and now software entrepreneur. Shkreli shares his side of the drug pricing controversy, reflects on his prison experience, and explains how he rebuilt his life and business after being "canceled." They div...

In this episode of Gradient Dissent, host Lukas Biewald talks with Sualeh Asif, the CPO and co-founder of Cursor, one of the fastest-growing and most loved AI-powered coding platforms. Sualeh shares the story behind Cursor’s creation, the technical and design decisions that set it apart, and how AI models are changing the way we build software. They dive deep into infrastructure challenges, the im...

In this episode of Gradient Dissent, host Lukas Biewald talks with Christopher Ahlberg, CEO of Recorded Future, a pioneering cybersecurity company leveraging AI to provide intelligence insights. Christopher shares his fascinating journey from founding data visualization startup Spotfire to building Recorded Future into an industry leader, eventually leading to its acquisition by Mastercard. They d...

In this episode of Gradient Dissent, host Lukas Biewald speaks with Captain Jon Haase, United States Navy about real-world applications of AI and autonomy in defense. From underwater mine detection with autonomous vehicles to the ethics of lethal AI systems, this conversation dives into how the U.S. military is integrating AI into mission-critical operations — and why humans will always be at the...

In this episode of Gradient Dissent, host Lukas Biewald sits down with João Moura, CEO & Founder of CrewAI, one of the leading platforms enabling AI agents for enterprise applications. Joe shares insights into how AI agents are being successfully deployed in over 40% of Fortune 500 companies, what tools these agents rely on, and how software companies are adapting to an agentic world. They als...

In this episode of Gradient Dissent , host Lukas Biewald sits down with Mike Knoop , Co-founder and CEO of Ndea , a cutting-edge AI research lab. Mike shares his journey from building Zapier into a major automation platform to diving into the frontiers of AI research. They discuss DeepSeek’s R1, OpenAI’s O-series models, and the ARC Prize , a competition aimed at advancing AI’s reasoning capabilit...

In this episode of Gradient Dissent , host Lukas Biewald sits down with David Cahn, partner at Sequoia Capital, for a compelling discussion on the dynamic world of AI investments. They dive into recent developments, including DeepSeek and Stargate, exploring their implications for the AI industry. Drawing from his articles, "AI's $200 Billion Question" and "AI's $600 Billion Question," David unpac...

In this episode of Gradient Dissent , Akshay Agrawal, Co-Founder of Marimo, joins host Lukas Biewald to discuss the future of collaborative AI development. They dive into how Marimo is enabling developers and researchers to collaborate seamlessly on AI projects, the challenges of scaling AI tools, and the importance of fostering open ecosystems for innovation. Akshay shares insights into building...

In this episode of Gradient Dissent, Joseph E. Gonzalez, EECS Professor at UC Berkeley and Co-Founder at RunLLM, joins host Lukas Biewald to explore innovative approaches to evaluating LLMs. They discuss the concept of vibes-based evaluation, which examines not just accuracy but also the style and tone of model responses, and how Chatbot Arena has become a community-driven benchmark for open-sourc...

In this episode of Gradient Dissent, Julian Green, Co-founder & CEO of Brightband, joins host Lukas Biewald to discuss how AI is transforming weather forecasting and climate solutions. They explore Brightband's innovative approach to using AI for extreme weather prediction, the shift from physics-based models to AI-driven forecasting, and the potential for democratizing weather data. Julian sh...

In this episode of Gradient Dissent, Jonathan Siddharth, CEO & Co-Founder of Turing, joins host Lukas Biewald to discuss the path to AGI. They explore how Turing built a "developer cloud" of 3.7 million engineers to power AGI training, providing high-quality code and reasoning data to leading AI labs. Jonathan shares insights on Turing’s journey, from building coding datasets to solving enterp...