Gladstone Audio News

The complex Rube Goldberg-like molecular machinery could inspire novel technology to study and treat disease. Read more about the Shipman Lab at Gladstone Institutes

Research in mice reveals how critical brain cells misfire in Alzheimer’s and identifies a targeted strategy to restore healthy brain rhythms. Read more about the Palop Lab at Gladstone Institutes.

Inspired by bacterial biology, the Gladstone-developed “Detectron” opens up new possibilities for disease research and potentially treatments. Read this story on gladstone.org Read more about the Shipman Lab 

A team of scientists at Gladstone Institutes and UC San Francisco discovered how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread, pointing to a new strategy for therapeutic intervention. Read this story on our website Learn more about the Ott Lab. 

An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies. Read this story on gladstone.org. Learn more about the Marson Lab.

A team of scientists from Gladstone and UCSF developed a new method to genetically edit myeloid cells, immune cells that act as the body’s first responders. Read this story on gladstone.org.  Learn more about Julia Carnevale's research. 

A new screening platform uncovers gene edits that enhance CAR-T cells’ ability to infiltrate and eliminate solid tumors. Read this story on Gladstone.org Read more about the Marson Lab

In a new study published in Science Translational Medicine, Gladstone scientists show that stem cell-derived spinal neurons can integrate into damaged neural networks in rats and improve breathing-related motor function after a traumatic spinal cord injury. Read this story on Gladstone.org Learn more about the Srivastava Lab

For decades, a DNA-based test for cardiovascular disease seemed to work for Europeans and others but not Africans. Gladstone scientists just discovered why, with implications for many other diseases. Read this story on gladstone.org Learn more about the Tcheandjieu Lab

By studying a gene linked to congenital heart defects, scientists uncovered a new mechanism for how small drops in protein levels scramble the 3D structure of DNA, resulting in disease. Read this story on gladstone.org. Read the scientific publication. 

New research shows low oxygen can help alleviate disease caused by defects in a mitochondrial quality control machinery. Read this story on Gladstone.org. Read the scientific publication. 

Gladstone scientists developed a new tool to trace how the brain clears “waste,” uncovering surprising new biology about how it keeps itself healthy. Read the study, published in  Cell. Read this story on gladstone.org.

Thirty years after discovering a gene, Shinya Yamanaka and his team show that it’s essential for keeping intestinal stem cells stable, offering insight into how tissues repair themselves. Read this story on our website. 

A new study upends long-held view about how DNA is stored, explaining how subtle shifts in gene activity contribute to cancer, aging, and other complex diseases. Read this story on gladstone.org.

Scientists at Gladstone expanded their retron-based genome editing technology beyond E. coli, showing it works in 15 diverse bacterial species. Read this article on gladstone.org.  Read the scientific publication. 

A team of scientists at Gladstone and UCSF created a new genetic roadmap that reveals hundreds of hidden players in HIV infection, including two proteins that stop HIV in its tracks. Read this story on gladstone.org. Read the scientific publication. 

New findings on the APOE4 gene variant point to a potential therapeutic target for Alzheimer’s disease.  Read this story on gladstone.org. Read the scientific publication. 

Trained on data spanning the human lifespan, the tool developed at Gladstone can predict genes associated with aging and age-related diseases. Details appear in new study led by Christina Theodoris, MD, PhD, whose team developed the model. Read this story on gladstone.org. Read the preprint. 

A team of Gladstone scientists, led by Nadia Roan, uncovered a new path toward life without daily HIV pills, suggesting that a common diabetes pill could help achieve long-term remission. Read this story on gladstone.org. Read the scientific publication. 

A team of scientists, led by Gladstone Investigator Nadia Roan, developed a novel tool, named HIV-seq, that could uncover new opportunities for treating HIV. Read the scientific publication Read this story on gladstone.org.

A new framework that matches vitamins with genetic diseases helped uncover that high-dose vitamin B3 can dramatically extend survival in mice with NAXD deficiency. Read this story on gladstone.org Read the scientific publication

A team of scientists discovered that red blood cells act as hidden glucose sponges in low-oxygen conditions, explaining why people living at high altitude have lower diabetes rates and pointing toward new treatments. Read this article on gladstone.org. Read the scientific publication. 

In a new study featured in Nature Cardiovascular Research, Gladstone scientists identified a cellular boundary that guides heart development and revealed how disrupting it can lead to holes in the heart’s wall. Read the scientific publication Read the article on Gladstone.org

A team of scientists at Gladstone developed a new gene editing method and showed that only a few variations of the therapy could treat the majority of patients with Charcot-Marie-Tooth disease. Read this article on gladstone.org Read the scientific publication. 

Gladstone Institutes researcher Alex Marson and his collaborators at Stanford University developed a genomic mapping technique that helps close the gap in understanding why certain genetic variants are tied to disease. Read this story on gladstone.org . Read the scientific publication.